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Medicine composition for treating chronic nephritis and preparation method thereof

A technology of chronic nephritis and composition, which is applied in the field of pharmaceutical composition for treating chronic nephritis and its preparation, which can solve the problems of poor patient compliance, sugar content, slow dissolution rate, etc., reduce the amount of excipients and drying time, and reduce the The effect of dosage and production cost saving

Active Publication Date: 2012-12-12
韩兵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The tablet prepared by this method takes 8 tablets each time and 24 tablets per day. The dosage of the finished medicine is large, and the patient's compliance is poor; and the disintegration is slow (about 20-50 minutes), and the dissolution rate Slow, slow absorption and effective effects, the preparation contains sugar, and there are certain limitations in clinical promotion and application

Method used

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  • Medicine composition for treating chronic nephritis and preparation method thereof
  • Medicine composition for treating chronic nephritis and preparation method thereof
  • Medicine composition for treating chronic nephritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation method of embodiment 1 pharmaceutical composition of the present invention

[0027] Raw materials of Chinese herbal medicine (unit: gram):

[0028] 4166g of scutellaria, 750g of Scutellaria baicalensis, 1000g of Shiwei, 1000g of astragalus

[0029] medical supplements:

[0030] Starch 43g

[0031] Its preparation method is, the above-mentioned 4 flavors of Chinese herbal medicines, except Scutellaria baicalensis, the remaining three flavors are decocted twice with water respectively, each time for 2 hours, the decoctions are combined, filtered, the filtrate is concentrated to an appropriate amount, and ethanol is added to make the alcohol content 70 %, stir well, let it stand still, take the supernatant to recover ethanol, concentrate under reduced pressure into a thick paste, dry, and pulverize; pulverize Scutellaria baicalensis into coarse powder, add water and soak at 80°C for three times, each time for 2 hours, and filter while hot After passing, ...

Embodiment 2

[0032] Embodiment 2 The preparation method of pharmaceutical composition of the present invention

[0033] Raw materials of Chinese herbal medicine (unit: gram):

[0034] 4166g of scutellaria, 750g of Scutellaria baicalensis, 1000g of Shiwei, 1000g of astragalus

[0035] medical supplements:

[0036] Starch 39g

[0037] Its preparation method is, the above-mentioned 4 flavors of Chinese herbal medicines, except Scutellaria baicalensis, the remaining three flavors are decocted twice with water respectively, each time for 2 hours, the decoctions are combined, filtered, the filtrate is concentrated to an appropriate amount, and ethanol is added to make the alcohol content 70 %, stir well, let it stand still, take the supernatant to recover ethanol, concentrate under reduced pressure into a thick paste, dry, and pulverize; pulverize Scutellaria baicalensis into coarse powder, add water and soak at 80°C for three times, each time for 2 hours, and filter while hot After passing, ...

Embodiment 3

[0038] Embodiment 3 The preparation method of pharmaceutical composition of the present invention

[0039] Raw materials of Chinese herbal medicine (unit: gram):

[0040] 4166g of scutellaria, 750g of Scutellaria baicalensis, 1000g of Shiwei, 1000g of astragalus

[0041] medical supplements:

[0042] Starch 45g

[0043] Its preparation method is, the above-mentioned 4 flavors of Chinese herbal medicines, except Scutellaria baicalensis, the remaining three flavors are decocted twice with water respectively, each time for 2 hours, the decoctions are combined, filtered, the filtrate is concentrated to an appropriate amount, and ethanol is added to make the alcohol content 70 %, stir well, let it stand still, take the supernatant to recover ethanol, concentrate under reduced pressure into a thick paste, dry, and pulverize; pulverize Scutellaria baicalensis into coarse powder, add water and soak at 80°C for three times, each time for 2 hours, and filter while hot After passing, ...

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Abstract

The invention provides a medicine composition for treating chronic nephritis. The medicine composition is a pellet prepared from the following raw materials and accessory in parts by weight: Chinese medicine herb raw materials: 4,166 parts of lespedeza virgata, 750 parts of radix scutellariae, 1,000 parts of folium pyrrosiae and 1,000 parts of radix astragali; and accessory: 39-98 parts of filler, wherein the filler is one of starch, soluble starch and dextrin or the mixture of more than two thereof. The invention also provides a preparation method of the medicine composition. In the invention, according to the physicochemical characteristics of the raw material extract of 'Shenyansiwei tablets', the raw materials are prepared into pellets and then encapsulated, thus relatively large drug loading capacity is ensured, and the problem that the medicine can not be prepared into hard capsules on the premise of reducing the dose of the patent medicine of the original dosage form is solved; and meanwhile, in the preparation process of pellets, by observing the pill forming method, the type of adhesive and wetting agent and the drying method, the dosage of the accessory and the drying time are further reduced, the production cost is effectively saved, and industrial production is possible.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating chronic nephritis and a preparation method thereof. Background technique [0002] "Shenyan Siwei Tablet" is a classic Chinese patent medicine. Recorded in Volume 12 of the National Standards of Chinese Patent Medicine, page 86, the standard number is WS 3 -B-2345-97, tablet made from four medicines of Rhododendron chinensis, Scutellaria baicalensis, Shiwei and Astragalus membranaceus. Shenyan Siwei Tablet has the functions of promoting blood circulation and removing blood stasis, clearing heat and detoxification, nourishing kidney and replenishing Qi, and is mainly used to treat chronic nephritis. It tastes bitter, so sugar-coated tablets are often used. The preparation is a tablet, and the prescription quantity is: 2083g of scutellaria baicalensis, 375g of Scutellaria baicalensis, 500g of Shiwei, and 500g of Astragalus membranaceus. After 2 hours, combine the decoction, filter, conc...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K9/48A61P13/12
Inventor 张明强
Owner 韩兵
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