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Method for separating cholesteryl ester from lanolin

A technology of cholesteryl ester and lanolin, which is applied in the field of chemical engineering, can solve the problems of low cholesteryl ester content, inability to obtain cholesteryl ester, and high energy consumption, and achieve the effects of simple process, high selective separation ability, and low consumption

Active Publication Date: 2014-03-12
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since the cholesterol in lanolin exists in free form except in a very small amount, most of it is combined with lanolin and exists in the form of ester, so these methods have all gone through the step of freeing cholesterol from cholesteryl ester, which consumes a lot of energy and cannot cholesteryl ester
Japanese patent JP6116584A adopts crystallization and column chromatography to extract cholesteryl ester from lanolin, but the obtained cholesteryl ester content is relatively low

Method used

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  • Method for separating cholesteryl ester from lanolin
  • Method for separating cholesteryl ester from lanolin

Examples

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Effect test

Embodiment 1

[0032] Lanolin (the mass percentage composition of cholesteryl ester is 25%) is dissolved in normal hexane and is made into the raw material liquid that lanolin total concentration is 10 g / liter, is extraction agent with acetonitrile, is washing agent with normal hexane, extraction agent, The flow ratio of detergent and raw material solution is 30:2:1, at 40°C figure 2 Fractional extraction is carried out in the fractionation extraction device shown (there are 10 stages in the extraction section and 10 stages in the washing section). The fractionation extraction is divided into an extraction section and a washing section. The last stage of the extraction section enters the fractionation extraction system, the detergent enters the fractionation extraction system from the first stage of the washing section, and the raw material liquid is combined into the extraction section at the last stage of the extraction section, and the extraction phase and the washing phase are subjected t...

Embodiment 2

[0034]Lanolin (the mass percentage composition of cholesteryl ester is 25%) is dissolved in n-hexane and is made into the raw material liquid that lanolin total concentration is 100 g / liter, with N-methylpyrrolidone as extractant, with n-hexane as detergent , the flow ratio of extractant, detergent and raw material solution is 50:20:1, at 30°C figure 2 Fractional extraction is carried out in the fractionation extraction device shown (there are 10 stages in the extraction section and 10 stages in the washing section). The fractionation extraction is divided into an extraction section and a washing section. The last stage of the extraction section enters the fractionation extraction system, the detergent enters the fractionation extraction system from the first stage of the washing section, and the raw material liquid is combined into the extraction section at the last stage of the extraction section, and the extraction phase and the washing phase are subjected to multi-stage cou...

Embodiment 3

[0036] Lanolin (the mass percentage composition of cholesteryl ester is 25%) is dissolved in cyclohexane and is made into the raw material liquid that lanolin total concentration is 0.5 g / liter, with 1,2-propanediol as extraction agent, with cyclohexane as The flow ratio of detergent, extractant, detergent, and raw material solution is 20:2:1, at 20°C figure 2 Fractional extraction is carried out in the fractionation extraction device shown (there are 10 stages in the extraction section and 10 stages in the washing section). The fractionation extraction is divided into an extraction section and a washing section. The last stage of the extraction section enters the fractionation extraction system, the detergent enters the fractionation extraction system from the first stage of the washing section, and the raw material liquid is combined into the extraction section at the last stage of the extraction section, and the extraction phase and the washing phase are subjected to multi-s...

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Abstract

The invention discloses a method for separating cholesteryl ester from lanolin. The method comprises the following steps of: (1) taking lanolin as a raw material, and preparing a raw material liquid from the lanolin and a hydrophobic organic solvent; carrying out fractional extraction by taking one or more than two mixed solvents from moderate polar or polar organic solvents as extracting agents and a solvent which is the same as the raw material liquid solvent as a washing agent to obtain extraction liquid; and (2) carrying out vacuum concentration, washing with water and drying to obtain the cholesteryl ester. In the method, the organic solvents which are frequently-used in the industry are adopted, and the cholesteryl ester with a higher content can be efficiently separated from the lanolin, so the method has the advantages of high separation efficiency, less solvent consumption, high productivity, low cost, safety, environmental protection, easy industrial production, and the like.

Description

technical field [0001] The invention relates to a compound separation method, belongs to the technical field of chemical engineering, and in particular relates to a method for separating cholesteryl ester from lanolin. Background technique [0002] Cholesterol is the first steroidal compound discovered, and it is one of the important components of animal organs, especially the brain and spinal cord tissue. It is also a raw material for the synthesis of bile acids, vitamin D and steroid hormones. Cholesteryl ester is a mixture of esters formed from cholesterol and a series of fatty acids with different carbon chain lengths. It has important applications in the fields of medicine, chemical industry, and cosmetics. [0003] Lanolin is a substance secreted by the sheep's sebaceous glands and adhered to the wool coat. It is mainly an ester formed by fatty acids and almost equal amounts of fatty alcohols, sterols, and trimethyl sterols. It also contains a small amount of free acid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J9/00
Inventor 鲍宗必梁瑞斯任其龙邢华斌苏宝根杨启炜杨亦文
Owner ZHEJIANG UNIV
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