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Resin ointment with high drug release, and preparation method and application thereof

A resin type and ointment technology, which is used in pharmaceutical formulations, medical preparations with non-active ingredients, and ointment transportation, can solve the problems of strong adhesion and poor drug release performance of resin type ointments, and achieve good drug release and stickiness. The effect of moderate patch performance and high drug release performance

Active Publication Date: 2012-10-17
NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the advantages of resin type ointment, it has attracted widespread attention, but resin type ointment has strong adhesion and poor drug release performance.

Method used

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  • Resin ointment with high drug release, and preparation method and application thereof
  • Resin ointment with high drug release, and preparation method and application thereof
  • Resin ointment with high drug release, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] 1. Preparation of resin paste

[0049]

[0050] With the above quality raw materials, proceed as follows:

[0051] 1. Add the thermoplastic elastomer SIS, plasticizer, and 50% antioxidant into the reactor, blow nitrogen for 5 minutes to remove the air, heat up until the mixture melts, and at the same time pass nitrogen protection, control the temperature between 120℃ and 150℃, stir , Until the mixture forms a uniform and transparent viscous colloid.

[0052] 2. Put the tackifying resin and the remaining 50% of the antioxidant into the above mixture, control the temperature between 100°C and 110°C, stir for half an hour, while protecting with nitrogen, until the mixture forms a uniform and transparent viscoelastic gel.

[0053] 3. Cool the above colloid to below 100°C and pour it out.

[0054] 2. Preparation of joint pain relief cream

[0055] 1. Prepare the traditional Chinese medicine resin ointment by the above method in Example 1;

[0056] 2. Weigh 100g of resin paste matrix, a...

Embodiment 2

[0095] 1. Preparation of resin paste

[0096]

[0097] Prepare according to the above composition ratio, and the method is the same as in Example 1.

[0098] 2. Preparation of Joint Pain Relieving Ointment: Repeat the method of Example 1 except that the resin paste base prepared in Example 2 is used to replace the base prepared in Example 1.

[0099] 3. Product testing:

[0100] The joint pain relief ointment prepared in Example 2 was investigated for initial viscosity, stickiness, peel strength, drug loading, and drug release performance. The method is the same as in Example 1. The test results are shown in Tables 4, 5, 6 and image 3 , Figure 4 .

[0101] Table 4

[0102]

[0103] The results in Table 4 show that the plaster prepared in Example 2 has moderate adhesion, peel strength between 1N and 2N, and good air permeability.

[0104] Table 5 Effects on the release of camphor in patches

[0105]

[0106] Table 5 and image 3 The results show that the plaster prepared in Example 2 ha...

Embodiment 3

[0111] 1. Preparation of resin paste:

[0112]

[0113] With the above quality raw materials, proceed as follows:

[0114] 1. Add the thermoplastic elastomer SIS, plasticizer, and 50% antioxidant into the reactor, blow nitrogen for 5 minutes to remove the air, heat up until the mixture melts, and at the same time pass nitrogen protection, control the temperature between 120℃ and 150℃, stir , Until the mixture forms a uniform and transparent viscous colloid.

[0115] 2. Put the tackifying resin and 50% antioxidant into the above mixture, control the temperature between 100°C and 110°C, stir for half an hour while protecting with nitrogen until the mixture forms a uniform and transparent viscoelastic gel; then add it Filler and organic acid, stir to make the dispersion uniform;

[0116] 3. Cool the above colloid to below 100°C and pour it out.

[0117] 2. Preparation of joint pain relief cream

[0118] 1. Prepare the traditional Chinese medicine resin ointment by the above method of Exam...

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Abstract

The invention discloses a resin ointment with high drug release. The resin ointment comprises the following components, by weight: 35%-50% of a thermoplastic elastomer SIS; 8%-30% of a tackifying resin selected from rosin resin, terpene resin, C5 petroleum resin, hydrogenated petroleum resin or random combinations thereof; 25%-45% of a plasticizer selected from liquid paraffin, Twain 80, dibutyl phthalate, lanolin, castor oil, naphthenic oil or random combinations thereof; 1%-3% of an antioxidant and / or an anti-aging agent selected from microcrystalline wax, propyl gallate, rubber accelerator or random combinations thereof; 0-24% of a filler selected from zinc oxide and titanium oxide; and 0-10% of an organic acid selected from citric acid and tartaric acid. In addition, the present invention also discloses the preparation method of the resin ointment and application thereof to a traditional Chinese medicine plaster product. The resin ointment of the invention has good skin initial tack, moderate peeling strength, no stimulation, good air permeability, high drug release performance and good compatibility with medicine.

Description

Technical field [0001] The invention relates to a medical ointment, in particular to a resin-type ointment; in particular, to a resin-type ointment with higher drug release performance; in addition, the invention also relates to a preparation method of the resin-type ointment. Background technique [0002] In traditional Chinese medicine transdermal administration, natural rubber is mainly used as the adhesive layer matrix. This type of rubber ointment is a patch made by mixing the medicinal material extract with the matrix and coating it on the backing material. Traditional rubber paste is easy to induce allergies because it contains natural rubber; in addition, organic solvents are added in the production, resulting in organic solvent residues, which is irritating to the skin, and the rubber paste has poor air permeability, skin irritation and allergic reactions. Rubber paste requires a lot of gasoline in the production, which is prone to explosion and has low safety productio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/70A61K47/44A61K47/32
Inventor 汤秀珍张皓王承潇杜晨捷樊敏伟
Owner NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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