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Preparation method of water soluble CdTe/CdS/ZnS nuclear/shell/shell type quantum dot

A water-soluble, quantum dot solution technology, applied in the field of nanomaterials, can solve the problems of poor fluorescence performance, poor biocompatibility, volatile odor, etc., and achieve high fluorescence quantum yield, good biocompatibility, and simple operation Effect

Inactive Publication Date: 2012-10-03
GUANGXI TEACHERS EDUCATION UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the fact that Te on the surface of CdTe nuclear quantum dots is easily oxidized and there are a large number of non-radiative recombination centers on the surface of CdTe quantum dots, the stability and fluorescence performance of CdTe quantum dots are poor.
Although the fluorescence quantum yield and fluorescence stability of quantum dots can be improved by coating a layer of CdS on the surface of CdTe quantum dots, the obtained CdTe / CdS core / shell quantum dots can still release toxic Cd 2+ , poor biocompatibility, not suitable for application in the fields of biomedicine and disease diagnosis
In addition, since these CdTe core-type quantum dots and CdTe / CdS core / shell-type quantum dots are mainly made of thioglycolic acid, mercaptopropionic acid, and mercaptoethylamines with poor stability, volatile odor, high toxicity, and poor biocompatibility. Molecules act as modifiers, greatly limiting the range of applications of these quantum dots

Method used

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  • Preparation method of water soluble CdTe/CdS/ZnS nuclear/shell/shell type quantum dot
  • Preparation method of water soluble CdTe/CdS/ZnS nuclear/shell/shell type quantum dot

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Embodiment 1

[0025] A preparation method of water-soluble CdTe / CdS / ZnS core / shell / shell type quantum dots, the steps are as follows:

[0026] (a) Prepare sodium tellurium hydride NaHTe solution as tellurium source: sodium borohydride NaBH with a molar ratio of 2:1 4 Put the tellurium powder Te in water, under the protection of nitrogen, stir and react at 80°C for 1h to obtain a sodium telluride hydride NaHTe solution;

[0027] (b) Under the protection of nitrogen, sodium hydride telluride NaHTe solution was added to cadmium chloride and N-acetyl-L-cysteine ​​solution at pH 12.0, so that Cd 2+ : N-acetyl-L-cysteine: the mol ratio of NaHTe is 1: 2: 0.05, at 90 ℃ of reflux 10min, solution is cooled to room temperature, obtains CdTe quantum dot solution;

[0028] (c) Under the protection of nitrogen, add N-acetyl-L-cysteine, cadmium chloride and sodium sulfide to the CdTe quantum dot solution obtained in the second step, and adjust the pH value to 12.0, so that Cd 2+ : N-acetyl-L-cysteine: S...

Embodiment 2

[0031] A preparation method of water-soluble CdTe / CdS / ZnS core / shell / shell type quantum dots, the steps are as follows:

[0032] (a) Prepare sodium tellurium hydride NaHTe solution as tellurium source: sodium borohydride NaBH with a molar ratio of 2:1 4 Put the tellurium powder Te in water, under the protection of nitrogen, stir and react at 80°C for 1h to obtain a sodium telluride hydride NaHTe solution;

[0033] (b) Under the protection of nitrogen, sodium hydride telluride NaHTe solution was added to cadmium chloride and N-acetyl-L-cysteine ​​solution at pH 12.0, so that Cd 2+ : N-acetyl-L-cysteine: the mol ratio of NaHTe is 1: 2: 0.05, at 90 ℃ of reflux 10min, solution is cooled to room temperature, obtains CdTe quantum dot solution;

[0034] (c) Under the protection of nitrogen, add N-acetyl-L-cysteine, cadmium chloride and sodium sulfide to the CdTe quantum dot solution obtained in the second step, and adjust the pH value to 12.0, so that Cd 2+ : N-acetyl-L-cysteine: S...

Embodiment 3

[0037] A preparation method of water-soluble CdTe / CdS / ZnS core / shell / shell type quantum dots, the steps are as follows:

[0038] (a) Prepare sodium tellurium hydride NaHTe solution as tellurium source: sodium borohydride NaBH with a molar ratio of 2:1 4Put the tellurium powder Te in water, under the protection of nitrogen, stir and react at 80°C for 1h to obtain a sodium telluride hydride NaHTe solution;

[0039] (b) Under the protection of nitrogen, sodium hydride telluride NaHTe solution was added to cadmium chloride and N-acetyl-L-cysteine ​​solution at pH 12.0, so that Cd 2+ : N-acetyl-L-cysteine: the mol ratio of NaHTe is 1: 2: 0.05, at 90 ℃ of reflux 10min, solution is cooled to room temperature, obtains CdTe quantum dot solution;

[0040] (c) Under the protection of nitrogen, add N-acetyl-L-cysteine, cadmium chloride and sodium sulfide to the CdTe quantum dot solution obtained in the second step, and adjust the pH value to 12.0, so that Cd 2+ : N-acetyl-L-cysteine: S ...

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Abstract

The invention discloses a preparation method of water soluble CdTe / CdS / ZnS nuclear / shell / shell type quantum dot. The method comprises the following steps of: preparing sodium hydrogen telluride NaHTe solution; preparing CdTe quantum dot solution; preparing water soluble CdTe / CdS nuclear / shell type quantum dot solution; and preparing water soluble CdTe / CdS / ZnS nuclear / shell / shell type quantum dot solution. The preparation method has the advantages of readily available raw materials, low cost and easiness in operation. The CdTe / CdS / ZnS nuclear / shell / shell type quantum dot prepared by the invention has the advantages of water solubility, adjustable fluorescence emission wavelength (540-710 nm), high fluorescence quantum yield (40-65 percent) and high bioavailability, and can be widely applied to the fields of biomedicines and disease diagnosis.

Description

technical field [0001] The invention belongs to the research fields of nanometer material technology, analytical chemistry, biomedicine and disease diagnosis, and specifically relates to a preparation method of water-soluble CdTe / CdS / ZnS core / shell / shell quantum dots. Background technique [0002] Water-soluble inorganic semiconductor nanomaterials—quantum dots, as a new type of fluorescent probe, have attracted extensive attention from researchers in many research fields. Compared with traditional organic fluorescent dyes and fluorescent proteins, quantum dots have very superior spectral properties, such as: higher fluorescence quantum yield, fluorescence emission wavelength can be adjusted with size and composition, wide and continuous excitation spectrum, narrow emission spectrum And symmetric, strong anti-photobleaching performance, high fluorescence stability. These superior spectral properties make quantum dots widely used in the fields of analytical chemistry, biomed...

Claims

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Application Information

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IPC IPC(8): C09K11/88C09K11/02
Inventor 黄珊肖琦苏炜
Owner GUANGXI TEACHERS EDUCATION UNIV
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