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Preparation method of benazepril hydrochloride tablets

A benazepril hydrochloride tablet and the technology of benazepril hydrochloride, which are applied in the field of preparation of benazepril hydrochloride tablets, can solve the burden on enterprises, the anti-sticking effect is not as good as that of magnesium stearate, and sticking is easy to occur, etc. , to achieve the effect of ensuring product quality and good physical isolation effect

Active Publication Date: 2012-10-03
SHANGHAI NEW ASIATIC PHARMA MINHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this also brings two problems: one is that the anti-adhesive effect of hydrogenated castor oil is not as good as that of magnesium stearate, and the performance of most domestic tablet presses is not as good as that of imported tablet presses. The process is still prone to sticking and punching. If you continue to use hydrogenated castor oil, you will need to spend a lot of money to update the tablet press, which will bring a burden to the enterprise; There are bound to be insurmountable policy barriers when using hydrogenated castor oil

Method used

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  • Preparation method of benazepril hydrochloride tablets
  • Preparation method of benazepril hydrochloride tablets
  • Preparation method of benazepril hydrochloride tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]

[0039] The preparation process is as follows:

[0040] Mix benazepril hydrochloride with the microcrystalline cellulose, lactose, polyvinylpolypyrrolidone of recipe quantity, join in the tank type mixer, stir 20 minutes, then add the 2% hypromellose solution of 1000g, Wet stirring for 7 minutes to obtain soft material, passing the soft material through a 20-mesh sieve to obtain wet granules, drying the wet granules at 60°C for 4 hours to obtain dry granules, and passing the dry granules through a 16-mesh sieve for sizing. The granules obtained after granulation were coated with gastric-soluble Opadry coating powder, and the coated granules were mixed with the prescribed amount of magnesium stearate in a V-type mixer for 10 minutes to measure the intermediate content. After determining the weight of the tablet, the tablet is pressed, and the plain tablet is packed.

Embodiment 2

[0042]

[0043] The preparation process is as follows:

[0044] Mix benazepril hydrochloride with the prescribed amount of microcrystalline cellulose, lactose, and 50 g of croscarmellose sodium evenly, use 2% hypromellose solution as a binder, and use a high-speed stirring granulator to carry out For granulation, the wet granules are dried with a boiling dryer, and the dry granules are sized through a 16-mesh sieve. The granules obtained after granulation are coated with gastric-soluble Opadry coating powder, and the coated granules are mixed with the prescribed amount of magnesium stearate and the remaining croscarmellose sodium in a V-shaped Mix in the machine for 10 minutes, measure the content of intermediates, press the tablet after determining the weight of the tablet, and pack the plain tablet.

Embodiment 3

[0046]

[0047] The preparation process is as follows:

[0048] Mix benazepril hydrochloride with prescription amount of microcrystalline cellulose, lactose, and 60g sodium starch glycolate, and use a dry granulator to granulate, and granulate with a 16-mesh sieve. The granules obtained after granulation are coated with gastric-soluble Opadry coating powder, and the coated granules are mixed with the magnesium stearate of the prescription amount and the remaining sodium starch glycolate in a V-shaped mixer for 10 minutes. Minutes, measure the intermediate content, determine the weight of the tablet, press the tablet, and pack the plain tablet.

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Abstract

The invention provides a preparation method of benazepril hydrochloride tablets. Benazepril hydrochloride which serves as an active component of the medicament is combined with auxiliaries filler, adhesive, disintegrating agent, lubricant magnesium stearate and a coating material to prepare particles, and the particles are made into tablets. The method is characterized in that the lubricant magnesium stearate is added after other components are granulated and coated, and the components are uniformly mixed and tableted. The preparation method can physically isolate benazepril hydrochloride from the magnesium stearate effectively, so that the problem that the variety over rises in the storage process, and the medicament quality is effectively controlled. The preparation method has high use value.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a preparation method of benazepril hydrochloride tablets for treating hypertension. Background technique [0002] Hypertension is the most common disease affecting human health today, and is an important risk factor for cardiovascular and cerebrovascular diseases. The direct complications include cerebrovascular accident, heart failure, renal failure, coronary heart disease, etc. Lowering blood pressure can significantly reduce the incidence of coronary heart disease, stroke and other blood vessels. The prevention and treatment of hypertension has always been a very important research topic, and the development of antihypertensive drugs with better curative effect and less side effects is also a global concern. New drugs targeting new and more effective targets and mechanisms of action have been developed and approved for marketing one after another. Each type of antih...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/55A61P9/12
Inventor 曾垂宇王佩芳商鼎
Owner SHANGHAI NEW ASIATIC PHARMA MINHANG
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