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Traditional Chinese medicine composition for treating uremia by being matched with hematodialysis, preparation method and application thereof

A technology of hemodialysis and composition, which is applied in the direction of drug combination, drug delivery, and pharmaceutical formulation, etc., can solve problems such as incomplete reasons, and achieve the effect of short course of treatment, high curative effect, and quick effect

Inactive Publication Date: 2013-10-30
如皋市江北添加剂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The cause of uremic hemodialysis complicated with pruritus is still not fully understood

Method used

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  • Traditional Chinese medicine composition for treating uremia by being matched with hematodialysis, preparation method and application thereof
  • Traditional Chinese medicine composition for treating uremia by being matched with hematodialysis, preparation method and application thereof
  • Traditional Chinese medicine composition for treating uremia by being matched with hematodialysis, preparation method and application thereof

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preparation example Construction

[0072] The present invention also provides a preparation method of the above-mentioned Chinese medicine composition, when the dosage form of the Chinese medicine composition is an oral liquid, it includes:

[0073] In the first step, the components of the traditional Chinese medicine composition are mixed according to the above proportions, crushed into powders of 100 mesh to 200 mesh, and the alcohol concentration is 75% to 85% ethanol for reflux extraction for 2 hours to 4 hours. The quality of the added ethanol is The first step is 3 to 5 times the mass of the mixture, filtered to obtain the filtered liquid medicine;

[0074] In the second step, the medicinal solution obtained after the first step is passed through a medium-polarity macroporous adsorption resin or a low-polarity macroporous adsorption resin, and firstly eluted with water or ethanol with a concentration lower than 20% as eluent until the The liquid is colorless, and the mass of water or ethanol with a concen...

Embodiment 1

[0083] The oral liquid 1 that embodiment 1 present invention prepares

[0084] Astragalus 70g, Codonopsis 85g, Yam 55g, Coix seed 15g, Safflower 25g, Rhubarb 60g, Vasong 15g, Dendrobium 25g, Longan meat 15g, Dandelion 25g, Angelica 30g, Kochia scoparia 15g, Kelp 15g, Motherwort 15g, Salvia miltiorrhiza Mix 30g, Phytolacca 15g, Morinda officinalis 20g, Yunzhi 15g, Psoralen 35g and Acanthopanax 30g, grind into 100 mesh powder, add alcohol concentration of 85% ethanol 2500g, reflux extraction for 2 hours, filter to obtain filter medicine solution, the drug solution obtained after the treatment is passed through the AB-8 type macroporous adsorption resin, and the ethanol 650g with a concentration of 10% is used as the eluent to elute until the eluent is colorless, and then the ethanol with a concentration of 95% 2500g elution, collect the ethanol eluate, adjust the pH value of the ethanol eluate to 7.5 with 0.5mol / L sodium hydroxide alkali solution, place, filter, concentrate and ...

Embodiment 2

[0090] Embodiment 2 Oral liquid 2 prepared by the present invention

[0091]Astragalus 68g, Codonopsis 83g, Yam 52g, Coix seed 15g, Safflower 22g, Rhubarb 63g, Vasong 13g, Dendrobium 22g, Longan meat 17g, Dandelion 27g, Angelica 33g, Kochia scoparia 18g, Kelp 18g, Motherwort 15g, Salvia miltiorrhiza 32g, Phytolacca 12g, Morinda officinalis 23g, Yunzhi 12g, Psoralen 32g and Acanthopanax 33g, mixed, crushed into 100 mesh powder, added alcohol concentration of 85% ethanol 2500g reflux extraction for 2 hours, filtered to obtain filter medicine solution, the drug solution obtained after the treatment is passed through the AB-8 type macroporous adsorption resin, and the ethanol 650g with a concentration of 10% is used as the eluent to elute until the eluent is colorless, and then the ethanol with a concentration of 95% 2500g elution, collect the ethanol eluate, adjust the pH value of the ethanol eluate to 7.5 with 0.5mol / L sodium hydroxide alkali solution, place, filter, concentrate...

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Abstract

The invention provides a traditional Chinese medicine composition for treating complication of uremia caused by hematodialysis, which comprises astragalus, dangshen, Chinese yam, semen coicis, carthamus tinctorius, frangula emodin, herba orostachyos, dendrobe, arillus longan, dandelion, angelica sinensis, fructus kochiae, kelp, motherwort, radix salviae miltiorrhizae, pokeberry root, morinda officinalis, trametes versicolor, fructus psoraleae and acanthopanax root. The traditional Chinese medicine composition can well treat the complication such as skin itch and malnutrition caused by hematodialysis, and has the advantages of being high in treatment effect, short in course of treatment and rapid in taking effect when being used for treating the uremia by being matched with hematodialysis.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine engineering, in particular to a traditional Chinese medicine composition for treating uremia with hemodialysis. Background technique [0002] Uremia is a clinical syndrome that occurs in the late stage of various chronic kidney diseases, which causes the retention of nitrogen and other metabolites in the body, and the hepatic clearance rate of endogenous muscle has often dropped to below 25%. [0003] Western medicine mainly adopts kidney transplantation and hemodialysis to treat uremia. Among them, hemodialysis is one of the main methods for treating uremia at present. While hemodialysis prolongs the life of uremic patients, there are also some problems, such as high cost and how to improve the sufficiency of dialysis and the nutritional status of patients. In patients with uremia, electrolyte and endocrine disorders, autonomic neuropathy, and some drugs such as calcium or a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8994A61K9/08A61K9/20A61P17/04A61P1/14
Inventor 董芳万喜超许梅
Owner 如皋市江北添加剂有限公司
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