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Water-soluble rare earth ion doped zirconium dioxide nano fluorescence labeling material and preparation method thereof

A zirconium dioxide and nano-fluorescence technology, applied in luminescent materials, chemical instruments and methods, etc., can solve the problems of large particle size, inability to realize the application of zirconium dioxide nano-materials, and no water-soluble luminous efficiency, etc., and achieve uniform particle size. , good water solubility and biocompatibility, small size effect

Active Publication Date: 2012-09-19
FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the rare earth ion zirconia nanocrystals studied at present have large particle sizes, and do not have water solubility and high luminous efficiency, so the application of rare earth doped zirconia nanomaterials in bioluminescence labeling cannot be realized.

Method used

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  • Water-soluble rare earth ion doped zirconium dioxide nano fluorescence labeling material and preparation method thereof
  • Water-soluble rare earth ion doped zirconium dioxide nano fluorescence labeling material and preparation method thereof
  • Water-soluble rare earth ion doped zirconium dioxide nano fluorescence labeling material and preparation method thereof

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Experimental program
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Effect test

example 1

[0014] Example 1: ZrO 2 : 0.05% Eu 3+ Preparation of Nanocrystals. Add 1.79 mL of n-propanol solution containing 70% zirconium n-propoxide, 0.0012 g of europium acetate and 20 mL of benzyl alcohol into a 50 mL polytetrafluoroethylene reactor, stir to mix evenly, and heat the above mixture to 230 ° C, kept at this temperature for 72 hours to make it fully react and precipitate, after cooling to room temperature naturally, centrifuge, and wash with ethanol several times. Obtain monodisperse, particle size less than 10 nm, tetragonal ZrO 2 : 0.05% Eu 3+ Nanocrystalline. The prepared nanocrystals were dispersed into 20 mL cyclohexane for later use. Use a spectrometer to detect its luminescence, and by exciting the zirconia matrix (excitation wavelength ~277 nm), the strong red luminescence of europium ions can be obtained.

example 2

[0015] Example 2: ZrO 2 : 0.5%Tb 3+ Preparation of Nanocrystals. Add 1.79 mL of n-propanol solution containing 70% zirconium n-propoxide, 0.012 g of terbium acetate and 20 mL of benzyl alcohol into a 50 mL polytetrafluoroethylene reactor, stir to mix evenly, and heat the above mixture to 230 ℃, kept at this temperature for 72 hours to allow it to fully react and precipitate, and after naturally cooling to room temperature, centrifuge and wash with ethanol for several times. Obtain monodisperse, particle size less than 10 nm, tetragonal ZrO 2 : 0.5% Tb 3+ Nanocrystalline. The prepared nanocrystals were dispersed into 20 mL cyclohexane for later use. The luminescence was detected by a spectrometer, and the strong green luminescence of terbium ions could be obtained by exciting the zirconia matrix (excitation wavelength ~277 nm).

example 3

[0016] Example 3: ZrO 2 : 4% Eu 3+ Preparation of Nanocrystals. Add 1.79 mL of n-propanol solution containing 70% zirconium n-propoxide, 0.0936 g of europium acetate and 20 mL of benzyl alcohol into a 50 mL polytetrafluoroethylene reactor, stir to mix evenly, and heat the above mixture to 230 ℃, kept at this temperature for 72 hours to allow it to fully react and precipitate, and after naturally cooling to room temperature, centrifuge and wash with ethanol for several times. Obtain monodisperse, particle size less than 10 nm, tetragonal ZrO 2 : 4%Eu 3+ Nanocrystalline. The prepared nanocrystals were dispersed into 20 mL cyclohexane for later use. Use a spectrometer to detect its luminescence, and by exciting the zirconia matrix (excitation wavelength ~277 nm), the strong red luminescence of europium ions can be obtained.

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Abstract

The invention discloses a water-soluble rare earth ion doped zirconium dioxide nano fluorescence labeling material and a preparation method thereof, relates to rare earth ion doped zirconium dioxide nano fluorescence labeling materials, and particularly relates to a method enabling rare earth ion doped zirconium dioxide nanocrystalline to have water solubility and biocompatibility. Rear earth ions are successfully doped into zirconium dioxide nanocrystalline by means of a high-temperature solvent thermal and ligand exchange method to obtain a monodispersed, water-soluble and highly-luminous zirconium dioxide nano fluorescence labeling material with rare earth ions. The composition of the zirconium dioxide nano fluorescence labeling material is xRE3+-(1-x) ZrO2 (RE=Eu, Tb; x=0-50mol%). High visible light transmission of matrix-sensitized rear earth ions can be realized by using a spectrometer to detect luminescence of samples and stimulating ZrO2 matrix.

Description

technical field [0001] The present invention relates to nano fluorescent labeling materials, especially to water-soluble rare earth doped zirconia (ZrO 2 ) Nano fluorescent labeling material and preparation method thereof. Background technique [0002] Rare earth doped rare earth oxide nanoparticles are a new type of luminescent material, which has broad application prospects in green lighting sources, nano-optoelectronic devices, flat panel displays, biomedical imaging, biomarkers and identification, etc., and has been favored by scholars at home and abroad. General concern. Among them, zirconium dioxide has stable physical and chemical properties, low phonon energy, and is a good luminescent substrate. And because the radius of zirconium ions is similar to that of rare earth ions, doping rare earth ions in the zirconium dioxide matrix can achieve high-efficiency rare earth ion luminescence. However, most of the rare earth ion zirconia nanocrystals studied at present hav...

Claims

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Application Information

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IPC IPC(8): C09K11/78
Inventor 陈学元唐海刘永升涂大涛李仁富朱浩淼
Owner FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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