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Preparation method and quality detection method of detoxification antidiarrheal tablet

A technology for antidiarrheal and slicing, which is applied in the field of preparation and quality inspection of Miao medicine, can solve the problems of complex quality inspection methods, many factors in preparation production, and complicated process production, so as to achieve advanced quality inspection methods and ensure product efficacy and quality. Standard Clear Effects

Inactive Publication Date: 2012-08-22
GUIZHOU BAIHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the existing preparations for the treatment of symptoms such as diarrhea, abdominal distension, abdominal pain, and acute enteritis caused by gastrointestinal dampness and heat, the preparations generally have complex production processes, many factors affecting the production of preparations, and quality standards are still relatively backward. And the quality inspection method is complicated, the controllability is not strong, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] a. Preparation of anti-sitting leaf powder: take 100g anti-sitting leaves, wash 10g of them, cut and dry, and crush to 120 mesh to prepare anti-sitting leaf powder;

[0024] b. Wash and slice the remaining 90g of the opposing leaves and add 15-19 times the prescription amount of water to decoct 3 times; add 19 times the prescription amount of water to the first decoction and cook for 2 hours, and then decoct the second time Boiling: Add 15 times the amount of water to the dregs of the first decocting and decocting for 1 hour, add 15 times the amount of dregs of the second decocting to the decocting for 1 hour, combine 3 times to collect the filtrate ;

[0025] c. Concentrate the resulting filtrate at a temperature of 70°C and a vacuum of -0.08MPa into a clear paste with a density of 1.10 to 1.20;

[0026] d. Mix the fine powder and clear ointment uniformly and dry at 60℃ to prepare granular preparation; add medicinal starch and 60% ethanol to the granular preparation obtained...

Embodiment 2

[0035] a. Preparation of fine powder for opposing leaves: Take 100g of opposing leaves, wash 5g of them, cut and dry, and crush to 110 mesh to obtain fine powder for opposing leaves;

[0036] b. Wash and slice the remaining 95g of the opposing leaves and add 15-19 times the prescription amount of water to decoct 3 times; add 19 times the prescription amount of water to the first decoction and cook for 2 hours, and then decoct the second time. Boiling: Add 17 times the amount of water to the dregs of the first decoction and cook for 1.5 hours, add 15 times the amount of the dregs of the second decocting to 15 times the amount of water for 1 hour, combine 3 times to collect the filtrate ;

[0037] c. Concentrate the resulting filtrate at a temperature of 60°C and a vacuum of -0.07MPa to a clear paste with a density of 1.10 to 1.20;

[0038] d. Mix the fine powder and clear ointment uniformly, and then dry them at a temperature of 50°C to obtain granules; add medicinal starch and 50% e...

Embodiment 3

[0047] a. Preparation of anti-sitting leaves fine powder: take 100g anti-sitting leaves, wash 15g of them, cut and dry, and crush to 130 meshes to prepare anti-sitting leaves powder;

[0048] b. Wash and slice the remaining 85g of the opposing leaves and add 15-19 times the prescription amount of water to decoct 3 times; add 19 times the prescription amount of water to the first decoction and cook for 2 hours, and then decoct the second time Boiling: Add 18 times the amount of water to decoct the medicine residue from the first decoction for 2 hours, add 15 times the amount of water to decoct the medicine residue from the second decoction for 1.5 hours, combine 3 times and collect the filtrate ;

[0049] c. Concentrate the resulting filtrate at a temperature of 70°C and a vacuum of 0.08 MPa into a clear paste with a density of 1.10 to 1.20;

[0050] d. Mix the fine powder and clear ointment uniformly and then dry them at a temperature of 60 ℃ to prepare granules; add medicinal starc...

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Abstract

The invention relates to a preparation method and a quality detection method of a detoxification antidiarrheal tablet. The antidiarrheal tablet has no adverse effect, toxic effect or side effect in long term clinical application, cannot stimulate an alimentary system, has no side effect on liver or kidney, cannot cause a series of adverse effects such as stomach discomfort, nausea, dizziness and the like, cannot generate drug resistance, and has remarkable effect on treatment on acute enteritis, syndrome drain abdominal distension in traditional Chinese medicine differentiation, abdominal pain and the like compared with traditional antidiarrheal. In preparation process, parts of medicinal materials are made into power, and parts of medicinal materials are extracted, so that effective components of products are ensured, production process is advanced, and production process is controllable. Simultaneously, raw material knowledge composition quercitin with strong specificity is adopted to serve as content control index, quality standard is explicit, quality checking method is advanced, terminal product quality is effectively controlled, and product curative effect can be ensured.

Description

Technical field [0001] The invention relates to a method for the preparation and quality detection of Miao medicine, in particular to a method for preparing Jieduzhixie tablets and a quality detection method. Background technique [0002] The anti-sitting leaves are derived from the long-segmented eargrass plant of the Rubiaceae family. Its main function is to expel wind and dampness, invigorate the spleen and reduce accumulation, clear away heat and detoxify; used for rheumatic joint pain, malnutrition in children, chronic diarrhea, dysentery, and teeth Chancre; topical treatment of skin itching, conjunctivitis. The chemical components of sitting leaves include oleanolic acid, quercetin and ursolic acid. The quality standard is to determine the content of oleanolic acid by thin-layer chromatography, which has the disadvantages of complicated operation, low sensitivity and large error. Quercetin was selected as the measurement index to establish a method for the determination of...

Claims

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Application Information

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IPC IPC(8): A61K36/748A61K9/36A61P1/12A61P1/14A61P39/02G01N33/15G01N30/90G01N30/02
Inventor 黄文荣马静文光均
Owner GUIZHOU BAIHUA PHARMA
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