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Externally-applied medicament composite for treating hemorrhoids

A technology for external use medicine and composition, applied in the field of medicine, can solve the problems such as single effect of external use medicine for hemorrhoids, single effect of external use medicine for hemorrhoids, insignificant effect and the like

Inactive Publication Date: 2012-08-22
段亚东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese Patent No. 2006100006751 discloses a hemorrhoid suppository containing two drug components, diosmin and hesperidin. Chinese Patent Application No. 2011104514725 also discloses a hemorrhoid topical drug containing diosmin, ruthin, and borneol. The effect of the hemorrhoid topical drug disclosed in the patent is also single
[0004] Existing topical medicines for hemorrhoids have single efficacy and insignificant curative effect, and there is no research on chitosan, topical anesthetics, glucocorticoids, sterilizing agents, calcium dobesilate or diosmin as external medicines for hemorrhoids and pharmaceutical production reports

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: suppository preparation

[0057] Prescription composition: calcium dobesilate 4.0g, chitosan 5.0g, polycresol sulfonal 3.0g, mixed fatty acid glyceride 88.0g, prepared into 100.0g gel.

[0058] Preparation method: mix calcium dobesilate, chitosan, and polycresol sulfonaldehyde evenly, then ultrafinely pulverize, and pass through a 80-100 mesh sieve to obtain the active ingredient powder of the drug; put the mixed fatty acid glyceride in a container Among them, it melts when heated at 100-105°C, heats it for 30 minutes to completely melt, and when the temperature is lowered to 65-75°C, add the raw material powder of the active ingredient of the drug, stir while adding, mix and stir evenly, and cool to 35-75°C. At 38°C, pour it into a suppository mold coated with lubricant, demould when cooled to a temperature of 18-22°C, perform quality inspection, and pack to obtain the hemorrhoid suppository.

Embodiment 2

[0059] Example 2: Gel Preparation

[0060]Prescription composition: calcium dobesilate 4.0g, chitosan 5.0g, lidocaine 2.0g, dexamethasone 0.025g, carbomer 0.8g, hypromellose 0.2g, hydrogenated hard castor oil 1.0g , Ethylparaben 0.025g, add water for injection to the full amount, and prepare 100.0g of gel.

[0061] Preparation method: mix calcium dobesilate, chitosan, lidocaine, and dexamethasone evenly, then ultrafinely pulverize, and pass through a 80-100 mesh sieve to obtain the raw material powder of the active ingredient of the drug, and dissolve it with an appropriate amount of water for injection , respectively mixed with hypromellose, hydrogenated hard castor oil, and ethyl paraben evenly, and heated to dissolve completely to form a solution of the active ingredient of the drug; sprinkle carbomer in water for injection, and stand still for 12 hours, Completely swell into a gel solution, add the active ingredient solution, stir evenly, sterilize by autoclaving, cooling...

Embodiment 3

[0062] Embodiment 3: ointment preparation

[0063] Prescription composition: calcium dobesilate 4.0g, chitosan 5.0g, artificial bezoar 1.0g, artificial musk 0.5g, ethylparaben 0.025g, add petrolatum base to the full amount, and prepare 100.0g ointment.

[0064] Preparation method: uniformly mix calcium dobesilate, chitosan, artificial bezoar, artificial musk, and ethylparaben, then ultrafinely pulverize, and pass through a 80-100 mesh sieve to obtain the raw material powder of the active ingredient of the medicine; The ointment base is heated at 75-85°C to melt to make it completely melted. When the temperature is 45-55°C, add the raw material powder of the active ingredient of the medicine, stir while adding, and mix evenly to obtain the ointment.

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Abstract

The invention belongs to the technical field of medicines and relates to an externally-applied medicament composite for treating hemorrhoids. More specifically, the externally-applied medicament composite is used for treating the hemorrhoids and consists of chitosan, surface anesthetics, glucocorticoid, a bacterial agent, calcium dobesilate or diosmin and acceptable medicament carriers. Calculus bovis factitious and muskone can be added into the externally-applied medicament composite, and the medicament composite is in the form of rectal suppository, anus gel or anus ointment, can be used after an operation for hemorrhoids or used for treating the hemorrhoids, anal fissure, perianal eczema and other anorectal diseases, has the advantages of being novel in medicament formula, effective in treatment and multi-purpose, and is superior to the existing hemorrhoids suppository and hemorrhoids ointment.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a medicinal composition for external use of hemorrhoids. Or an external pharmaceutical composition composed of diosmin and a pharmaceutically acceptable carrier. Background technique [0002] Hemorrhoids are the most common anorectal diseases in humans. The incidence rate in my country is about 50-70%. About 90% of hemorrhoids patients are treated with external medicines. The dosage forms of external medicines are mainly suppositories and ointments. Most external hemorrhoid medicines marketed in China are traditional Chinese medicine preparations, such as: Amendment Hemorrhoid Suppository, Jiuhua Hemorrhoid Suppository, Mayinglong Musk Hemorrhoid Suppository, Yunnan Baiyao Hemorrhoid Suppository, Puji Hemorrhoid Suppository, Sanwei Hemorrhoid Suppository, Compound Tengguo Hemorrhoid Suppository, Dragon Blood Drain Hemorrhoid suppository, Huatuo hemorrhoid suppository, Yunnan Baiy...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61K31/795A61K31/722A61P9/14A61P17/00A61K35/32A61K31/573A61K31/7048A61K31/4164A61K31/245A61K31/185A61K31/167A61K31/155A61K35/55
Inventor 段亚东
Owner 段亚东
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