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Cordyceps sinensis freeze-dried nano powder tablet and preparation method thereof

A technology of Cordyceps sinensis and nano-powder, which is applied in food preparation, pharmaceutical formulations, medical preparations containing active ingredients, etc.

Active Publication Date: 2012-08-15
三普药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In a word, it is not yet known that Cordyceps sinensis is crushed into nano-scale fineness under low temperature conditions, and the pure powder of Cordyceps sinensis nanopowder is used to prepare conventional oral solid preparations (such as tablets, hard capsules, soft capsules, pills, granules, powders, etc.) , dispersible tablets, sustained-release tablets) reports

Method used

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  • Cordyceps sinensis freeze-dried nano powder tablet and preparation method thereof
  • Cordyceps sinensis freeze-dried nano powder tablet and preparation method thereof
  • Cordyceps sinensis freeze-dried nano powder tablet and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0099] Preparation of reference substance solution: Accurately weigh 2.52 mg of adenosine reference substance and 1.03 mg of cordycepin dried to constant weight, put them in a 50ml volumetric flask, add 90% methanol to dissolve and constant volume, and obtain a mixed reference substance solution.

[0100] Preparation of the test solution: take the test product dried to constant weight, grind it into a fine powder, take 0.5g, weigh it accurately, put it in a stoppered Erlenmeyer flask, add 10ml of 90% methanol precisely, seal it tightly, and shake well , weighed, heated to reflux for 30min, allowed to cool, weighed again, supplemented the lost weight with 90% methanol, shook well, filtered through a 0.45μm microporous membrane, took the subsequent filtrate, or took the above eluate with a 0.45μm The membrane filtration is the test solution.

[0101] Preparation of standard curve: Precisely draw and mix 2.0, 6.0, 10.0, 14.0, 18.oml of the reference substance solution respectivel...

Embodiment 1

[0122] Specification: 0.25g / piece

[0123] prescription:

[0124] Cordyceps nanopowder 2.5kg purified water 5kg production 10000 capsules

[0125] Preparation method:

[0126] 1) Pretreatment of Cordyceps sinensis by screening and removing impurities to remove impurities such as weeds and sediment.

[0127] 2) Dry the pretreated Cordyceps sinensis obtained in step 1) at 50° C., and the moisture content of the dried Cordyceps sinensis is 3.4%.

[0128] 3) Put the dried Cordyceps sinensis into the tank of the high-energy nano ball mill, put in the zirconia balls, close the feeding port, pass tap water into the jacket around the tank to circulate and cool, and turn on the ball mill for grinding. The grinding time is 5 hours, the Cordyceps sinensis nanopowder was obtained, and the particle diameter was 575-800nm.

[0129] 4) Add 2.5 kg of Cordyceps nanopowder obtained in step 3) into 5 kg of purified water, and mix in a homogenizer to prepar...

Embodiment 2

[0134] Specification: 0.25g / piece

[0135] prescription:

[0136] Cordyceps nanopowder 2.5kg purified water 10kg production 10000 capsules

[0137] Preparation method:

[0138] 1) Pretreatment of Cordyceps sinensis by screening and removing impurities to remove impurities such as weeds and sediment.

[0139] 2) Dry the pretreated Cordyceps sinensis obtained in step 1) at 60° C., and the moisture content of the dried Cordyceps sinensis is 4.2%.

[0140] 3) Put the dried Cordyceps sinensis into a pulverizer and pulverize them into coarse powder of Cordyceps sinensis, and pass through a 10-mesh sieve.

[0141] 4) Put the coarse powder of Cordyceps sinensis into the high-energy nano ball mill tank, put the zirconia balls in, close the feeding port, pass tap water into the jacket around the tank to circulate and cool, turn on the ball mill, and vibrate the grinding time for 3 hours, Cordyceps sinensis nanopowder is obtained, and the particle ...

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Abstract

The invention relates to cordyceps sinensis nano powder, cordyceps sinensis freeze-dried nano powder tablet and a preparation method of the cordyceps sinensis freeze-dried nano powder tablet, belonging to the field of medicaments and health care products. The cordyceps sinensis freeze-dried nano powder tablet is obtained by carrying out freeze-drying on the cordyceps sinensis nano powder only containing cordyceps sinensis total component or is obtained by smashing a freeze-dried product into coarse powder and then pressing the coarse powder into tablets, wherein particle size of the cordyceps sinensis nano powder is 10-800nm. Under protection of a jacket cooling device, a high-energy nano ball mill is adopted for smashing cordyceps sinensis into nanoscale micro powder, the particle size of the smashed cordyceps sinensis is 10-800nm, the smashed cordyceps sinensis nano powder is added into appropriate amount of purified water to be made into cordyceps sinensis nano powder homogeneous size, vacuum freeze-drying is directly carried out to obtain freeze-dried tablets, or freeze-dried products with different moisture contents are made, then the cordyceps sinensis nano powder is added and is pressed into tablets, and packaging is carried out to obtain the cordyceps sinensis freeze-dried nano powder tablet. The cordyceps sinensis freeze-dried nano powder tablet disclosed by the invention has no tonic loss or damage, good taste and uniform and stable product quality, can be rapidly disintegrated, has high human bioavailability and is convenient to carry and use.

Description

technical field [0001] The invention relates to a cordyceps sinensis nanopowder, a cordyceps sinensis freeze-dried nanopowder sheet and a preparation method thereof, belonging to the field of medicine and health care products. Background technique [0002] Cordyceps sinensis is a complex of larvae and larvae of Cordyceps sinensis (Berk.) Sacc., a plant of the genus Cordyceps of the family Ergotaceae (Hypocreataceae), which parasitizes on the larvae of the bat moth Hepialus armoricanus Oberthur. my country's traditional precious Chinese medicinal materials are mostly grown in alpine mountainous areas, grasslands, valleys, and grass, and are distributed in Gansu, Qinghai, Sichuan, Yunnan, Tibet and other provinces. Chinese medicine believes that Cordyceps sinensis enters the two meridians of the lung and kidney, which can not only nourish the lung yin, but also nourish the kidney yang. The only traditional Chinese medicine that can balance and regulate Yin and Yang at the same...

Claims

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Application Information

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IPC IPC(8): A61K36/068A61K9/20A61K9/28A61P1/14A61P15/10A61P11/00A23L1/29A23L33/00
Inventor 张国清邹存生薛洪发
Owner 三普药业有限公司
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