Ferroferric oxide calcium phosphate nuclear shell magnetic nanoparticle and preparation method thereof by biological mineralization method

A technology of calcium ferrophosphate and nano-magnetic particles, which can be used in medical preparations of non-active ingredients, pharmaceutical formulas, and pharmaceutical sciences. It can solve problems such as poor structure and material composition, and achieve high saturation magnetization. The effect of rich, uniform particle size distribution

Active Publication Date: 2014-04-02
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to solve technical problems such as poor material structure and material composition existing in the prior art, and provides a nano-magnetic particle with a biologically active core-shell structure and a preparation method thereof

Method used

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  • Ferroferric oxide calcium phosphate nuclear shell magnetic nanoparticle and preparation method thereof by biological mineralization method
  • Ferroferric oxide calcium phosphate nuclear shell magnetic nanoparticle and preparation method thereof by biological mineralization method
  • Ferroferric oxide calcium phosphate nuclear shell magnetic nanoparticle and preparation method thereof by biological mineralization method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Dissolve 1.5 g of polyethylene glycol (Mw=4000) in 15 ml of deionized water, and stir mechanically for more than 12 hours. Weigh 1.789g of ferrous chloride, dissolve it in 15ml of deionized water, stir until completely dissolved, and add it into the polyethylene glycol solution. Slowly add 17ml of 2.5% ammonia solution dropwise while mechanically stirring; then add dropwise 5ml of 3% hydrogen peroxide; then add 50ml of deionized water. To ensure that the pH of the system was 11, the above mixed solution was transferred to a water bath at 60° C., and the mechanical stirring was continued for 1 hour. After the reaction, the obtained precipitate was separated from the reaction medium by using an external magnetic field, and washed 5 times with deionized water. Finally, the precipitate is put into a freeze-drying box to dry to obtain ferric oxide nano-magnetic particles.

[0024] (2) Put the prepared iron ferric oxide nano-magnetic particles and sodium citrate into de...

Embodiment 2

[0029] (1) Dissolve 1.5 g of polyethylene glycol (Mw=4000) in 15 ml of deionized water, and stir mechanically for more than 12 hours. Weigh 1.789g of ferrous chloride, dissolve it in 15ml of deionized water, stir until completely dissolved, and add it into the polyethylene glycol solution. Slowly add 17ml of 2.5% ammonia solution dropwise while mechanically stirring; then add dropwise 5ml of 3% hydrogen peroxide; then add 50ml of deionized water. To ensure that the pH of the system was 11, the above mixed solution was transferred to a water bath at 160° C., and the mechanical stirring was continued for 1 hour. After the reaction, the obtained precipitate was separated from the reaction medium by using an external magnetic field, and washed 5 times with deionized water. Finally, the precipitate is put into a freeze-drying box to dry to obtain ferric oxide nano-magnetic particles.

[0030] (2) Put the prepared iron ferric oxide nano-magnetic particles and sodium citrate into d...

Embodiment 3

[0034] (1) Dissolve 1.5 g of polyethylene glycol (Mw=4000) in 15 ml of deionized water, and stir mechanically for more than 12 hours. Weigh 1.789g of ferrous chloride, dissolve it in 15ml of deionized water, stir until completely dissolved, and add it into the polyethylene glycol solution. Slowly add 17ml of 2.5% ammonia solution dropwise while mechanically stirring; then add dropwise 5ml of 3% hydrogen peroxide; then add 50ml of deionized water. To ensure that the pH of the system was 10, the above mixed solution was transferred to a water bath at 100° C., and the mechanical stirring was continued for 1 hour. After the reaction, the obtained precipitate was separated from the reaction medium by using an external magnetic field, and washed 5 times with deionized water. Finally, the precipitate is put into a freeze-drying box to dry to obtain ferric oxide nano-magnetic particles.

[0035] (2) Put the prepared iron ferric oxide nano-magnetic particles and sodium citrate into d...

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Abstract

The invention discloses a ferroferric oxide calcium phosphate nuclear shell magnetic nanoparticle and a preparation method thereof by a biological mineralization method and belongs to the technical field of magnetic particles. A magnetic ferroferric oxide nanoparticle serves as a core, wherein the mean grain size of the particle is 27 to 38nm; and a calcium phosphate material serves as a shell layer, wherein the thickness of the shell layer is 4 to 20nm. The preparation method comprises the following steps that the ferroferric oxide magnetic nanoparticle is prepared and then is modified by a surface modifier; the modified ferroferric oxide magnetic nanoparticle is added into simulated human body fluid which is prepared and has the concentration of 1 to 10 times; the modified ferroferric oxide magnetic nanoparticle is mineralized; and the product is washed, subjected to magnetic separation and dried to obtain the ferroferric oxide calcium phosphate nuclear shell magnetic nanoparticle. The preparation method is simple in operation, mild in preparation process condition, wide in raw material source and environment friendly. The prepared nuclear shell nanoparticle has biological activity and has good application prospect in the field of biomedicine, such as tissue engineering and medicine carrying.

Description

technical field [0001] The invention relates to a nano-magnetic particle with a biologically active core-shell structure and a preparation method thereof, in particular to a biomineralization method for preparing ferric ferric oxide calcium phosphate core-shell nano-magnetic particle, which belongs to the technical field of magnetic particles. technical background [0002] Ferroferric oxide is a very important magnetic material with a cubic reverse spinel structure. Its unique electrical and magnetic properties make it widely used in magnetic fluids and magnetic recording materials. For nanometer scale Fe3O4, due to its compatibility with biological tissues, electrical and magnetic properties related to size and shape, it has been widely used in the field of biomedicine. Superparamagnetic iron oxide nanoparticles with suitable surface chemistry can be used in numerous in vivo applications, such as in vivo magnetic resonance contrast enhancement, tissue repair, immunoassay, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/50A61K47/04
Inventor 杨小平滕瑜蔡晴李可雨段顺邓旭亮
Owner BEIJING UNIV OF CHEM TECH
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