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Multi-action mode hydrophilic organic polymer monolithic column

A hydrophilic organic, monolithic column technology, applied in the field of analytical chemistry, can solve problems such as application limitations, and achieve the effects of increasing dosage, enriching π-π interaction, and increasing solubility

Active Publication Date: 2012-07-25
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of functional monomers containing benzene rings in the preparation of polar stationary phases is limited due to their poor solubility in polar porogens and crosslinkers

Method used

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  • Multi-action mode hydrophilic organic polymer monolithic column
  • Multi-action mode hydrophilic organic polymer monolithic column

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Ionic monomer: N,N,N-trimethylvinylbenzyl ammonium chloride, crosslinker: tris-2-acrylic acid[2,4,6-trioxo-1,3,5-triazine -1,3,5(2H,4H,6H)-methine]tri-2,1-ethylene ester, initiator: azobisisobutyronitrile, mixed porogen: mass ratio of methanol to dodecanol Prepared according to the following data respectively:

[0021] Column A: crosslinker 9%, ionic monomer: 11%, dodecanol: 35%, methanol: 44%, initiator 1%.

[0022] Column B: crosslinker 9%, ionic monomer: 11%, dodecanol: 38%, methanol: 41%, initiator 1%.

[0023] Column C: crosslinker 9%, ionic monomer: 11%, dodecanol: 41%, methanol: 38%, initiator 1%.

[0024] Column D: crosslinker 9%, ionic monomer: 11%, dodecanol: 44%, methanol: 35%, initiator 1%.

[0025] Column E: crosslinker 10%, ionic monomer: 10%, dodecanol: 38%, methanol: 41%, initiator 1%.

[0026] Column F: crosslinker 8%, ionic monomer: 12%, dodecanol: 38%, methanol: 41%, initiator 1%.

[0027] Column G: crosslinker 7%, ionic monomer: 13%, dodecanol: ...

Embodiment 2

[0030] Using the monolithic column B prepared above, using acetonitrile:ammonium formate buffer (5mmol / L, pH 4.5)=90:10 as the mobile phase, separation voltage +18 kV, the nucleosides and bases were separated by capillary electrochromatography, Under the joint action of hydrophilic interaction, π-π interaction and electrostatic interaction provided by the monolithic column, 9 nucleosides and bases were quickly separated, and the elution peaks were as follows: 1. Uracil, 2. Adenine, 3. Uridine, 4. Adenosine, 5. Inosine, 6. Cytosine, 7. Guanine, 8. Cytidine, 9. Guanosine.

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Abstract

The invention discloses a multi-action mode hydrophilic organic polymer monolithic column, which consists of a benzene-ring group-containing organic ionic monomer, an acrylate crosslinking agent, an initiator, and a pore-forming agent. The benzene-ring group-containing organic ionic monomer is N, N, N-trimethyl(vinylbenzyl)ammonium chloride, the crosslinking agent is 2-propenoic acid, (2,4,6-trioxo-1,3,5-triazine-1,3,5(2H,4H,6H)-triyl)tri-2,1-ethanediyl ester, the pore-forming agent is a mixture of methanol and dodecanol, and the initiator is azodiisobutyronitrile. The inventive capillary chromatographic column can provide hydrogen bonds and ion exchange interaction, but also can provide rich pi-pi interaction, and can meet the rapid separation requirements of neutral, acidic and alkaline polar substances.

Description

technical field [0001] The invention belongs to the field of analytical chemistry, and in particular relates to a hydrophilic organic polymer monolithic column with multiple action modes. Background technique [0002] Capillary electrochromatography is an efficient and fast new chromatographic micro-separation technology developed in recent years. As one of the main types of capillary chromatographic columns, capillary monolithic column has the characteristics of easy preparation, easy surface modification and high permeability, making it a good choice for micro-separation. Organic polymer monolithic columns in capillary monolithic columns have been widely used in micro-separation systems due to their simple synthesis steps, reliable chromatographic performance, and convenient control of pore structure and surface chemical properties. [0003] Most of the organic polymer monolithic columns studied now are non-polar stationary phases based on the principle of reversed-phase ...

Claims

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Application Information

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IPC IPC(8): B01D15/22B01J20/26B01J20/30
Inventor 林旭聪林葭李燕平谢增鸿
Owner FUZHOU UNIV
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