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Chinese medicinal compound gel for treating osteoarthrosis and preparation method thereof

A compound gel, a technology for osteoarthritis, applied in the field of medicine, can solve the problems of achieving effective blood drug concentration, affecting drug efficacy, difficult to grasp the dose, etc., achieving good therapeutic effect, avoiding gastrointestinal irritation, and reducing administration effect of times

Inactive Publication Date: 2012-07-18
梁文清 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the oral preparations of traditional Chinese medicine often contain highly toxic drugs such as Aconitum Aconiti, Araceae, and Nuxyche, and the dose is difficult to control. From the perspective of biopharmaceuticals, it is difficult to achieve effective blood drug concentration in the lesion, which affects the efficacy of the drug.
[0004] The theory of "external treatment of internal diseases" in traditional Chinese medicine has a long history and has accumulated a large number of good and proven prescriptions. However, traditional Chinese medicine for external treatment generally has disadvantages such as backward dosage forms, large doses, and inconvenient use. The external use of traditional Chinese medicine preparations is particularly important

Method used

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  • Chinese medicinal compound gel for treating osteoarthrosis and preparation method thereof
  • Chinese medicinal compound gel for treating osteoarthrosis and preparation method thereof
  • Chinese medicinal compound gel for treating osteoarthrosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A Chinese medicine compound gel for treating osteoarthritis is prepared.

[0029] The formula and ratio of the Chinese medicine compound gel of the present invention:

[0030]

[0031]

[0032] The preparation method of the extract of Radix serrata: pulverize the medicinal material of Radix serrata to the coarsest powder, and extract with 70% acidic ethanol (pH=3) percolation, collect 8 times the amount of percolate, and decompress the percolate to recover ethanol Concentrate in a water bath to a relative density of 1.05 (thermally measured at 60°C), filter, adjust the pH to 9 with ammonia water, and extract 5 times with chloroform until there is no alkaloid reaction. Combine the extracts and recover the chloroform to obtain a clear paste. Press and dry to get the raw cypress extract.

[0033] The preparation method of araceae extract: pulverize the araceae medicinal materials, extract with 70% acidic ethanol (pH=3), collect 10 times the amount of percolate, decompress the pe...

Embodiment 2

[0036] A Chinese medicine compound gel for treating osteoarthritis is prepared.

[0037] The formula and ratio of the Chinese medicine compound gel of the present invention:

[0038]

[0039] The preparation method of the extract of Radix serrata: pulverize the medicinal material of Radix serrata to the coarsest powder, and extract with 70% acidic ethanol (pH=3) percolation, collect 8 times the amount of percolate, and decompress the percolate to recover ethanol , Concentrate in a water bath to a relative density of 1.06 (thermally measured at 60°C), filter, adjust the pH to 9 with ammonia water, extract 5 times with chloroform, until there is no alkaloid reaction, combine the extracts, and recover the chloroform to obtain a clear paste. Press and dry to get the raw cypress extract.

[0040] The preparation method of araceae extract: pulverize araceae medicinal materials, extract with 70% acidic ethanol (pH=3), collect 10 times the amount of percolate, decompress the percolate to re...

Embodiment 3

[0043] A Chinese medicine compound gel for treating osteoarthritis is prepared.

[0044] The formula and ratio of the Chinese medicine compound gel of the present invention:

[0045]

[0046] The preparation method of the extract of Radix serrata: pulverize the medicinal material of Radix serrata to the coarsest powder, and extract with 70% acidic ethanol (pH=3) percolation, collect 8 times the amount of percolate, and decompress the percolate to recover ethanol Concentrate in a water bath to a relative density of 1.07 (thermally measured at 60°C), filter, adjust the pH value of the filtrate to 10 with ammonia, and extract 5 times with chloroform until there is no alkaloid reaction. Combine the extracts and recover the chloroform to obtain a clear paste. Press and dry to get the raw cypress extract.

[0047] The preparation method of araceae extract: pulverize the araceae medicinal material, extract with 70% acidic ethanol (pH=3), collect 10 times the amount of percolate, decompress...

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Abstract

The invention relates to the technical field of pharmacy, and discloses a Chinese medicinal compound gel for treating osteoarthrosis and a preparation method thereof. Unprocessed radix aconite, arisaema consanguineum schott, musk and the like are used as main drugs, a modern preparation technology is adopted to extract and refine the main drugs to prepare an external gel. Irritation to gastrointestinal tracts caused by oral administration can be avoided, the blood concentration of the whole body is reduced, and toxic or side effect is reduced; and the preparation method is simple and convenient for using, so that the administration compliance of the patient is improved, and a new medicament is provided for clinical treatment of osteoarthrosis.

Description

Technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine compound gel for treating osteoarthritis and a preparation method thereof. Background technique [0002] Osteoarthropathy (bone hyperplasia, intervertebral disc herniation, etc.) is a clinically common and frequently intractable disease, belonging to the category of Chinese medical arthralgia. Epidemiological surveys show that the incidence of this disease in the middle-aged and elderly population in my country is as high as 70%, of which the cervical spine, lumbar spine and knee joint have the highest incidence, and the three together account for more than 90% of bone and joint diseases. As my country gradually enters This problem will become more prominent in an aging society. [0003] In the existing methods of treating osteoarthritis, Western medicine often uses oral non-steroidal antipyretic analgesics or "traction" and other surgical treatments. Oral drugs h...

Claims

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Application Information

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IPC IPC(8): A61K36/8884A61K36/714A61K47/38A61K47/32A61K9/06A61P19/02A61P29/00
Inventor 梁文清钱宇刘继勇
Owner 梁文清
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