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Dental implant and preparation method thereof

A dental implant and implant technology, applied in dental preparations, dental prostheses, dentistry, etc., can solve problems such as cumbersome steps, achieve the effect of increasing the rate of osseointegration, improving the success rate of implantation, and shortening the time of osseointegration

Active Publication Date: 2014-05-14
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The diameter of the microspheres in the above method is about 30-100 μm, completely covering the original shape of the dental implant, and after loading, it needs to be stored at -20°C or -80°C to ensure its activity; Multi-step preparation of PDLA, PDLLA, etc., before loading with BMP and other proteins, the loading time is at least 48 hours

Method used

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  • Dental implant and preparation method thereof
  • Dental implant and preparation method thereof
  • Dental implant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1) Select pure titanium to process it into a dental implant matrix. After the surface of the dental implant matrix is ​​polished, it is ultrasonically cleaned with acetone, absolute ethanol and deionized water for 30 minutes, and then dried for use;

[0036] 2) Configure the electrolyte solution for the micro-arc oxidation process: deionized water is used as the solvent, and the solute is 0.04M β-sodium glycerophosphate and 0.2M calcium acetate;

[0037] 3) The micro-arc oxidation coating with micro-nano morphology was prepared on the outer surface of the implant substrate by the micro-arc oxidation process: the stainless steel tank was used as the cathode, and the dental implant substrate was used as the anode, which was placed in the electrolyte prepared in the previous step. The process parameters are: power frequency 100Hz, voltage 400V, duty cycle 20%, processing time 5min, reaction temperature is room temperature;

[0038] 4) After the preparation of the titanium ...

Embodiment 2

[0042] 1) Select pure titanium to process it into a dental implant matrix. After the surface of the dental implant matrix is ​​polished, it is ultrasonically cleaned with acetone, absolute ethanol and deionized water for 30 minutes, and then dried for use;

[0043] 2) Configure the electrolyte solution for the micro-arc oxidation process: deionized water is used as the solvent, and the solute is 0.04M β-sodium glycerophosphate and 0.2M calcium acetate;

[0044] 3) The micro-arc oxidation coating with micro-nano morphology was prepared on the outer surface of the implant substrate by the micro-arc oxidation process: the stainless steel tank was used as the cathode, and the dental implant substrate was used as the anode, which was placed in the electrolyte prepared in the previous step. The process parameters are: power frequency 100Hz, voltage 400V, duty cycle 20%, processing time 4min, and reaction temperature at room temperature;

[0045] 4) After the preparation of the titan...

Embodiment 3

[0049] 1) Select pure titanium to process it into a dental implant matrix. After the surface of the dental implant matrix is ​​polished, it is ultrasonically cleaned with acetone, absolute ethanol and deionized water for 30 minutes, and then dried for use;

[0050] 2) Configure the electrolyte solution for the micro-arc oxidation process: deionized water is used as the solvent, and the solute is 0.04M β-sodium glycerophosphate and 0.2M calcium acetate;

[0051] 3) The micro-arc oxidation coating with micro-nano morphology was prepared on the outer surface of the implant substrate by the micro-arc oxidation process: the stainless steel tank was used as the cathode, and the dental implant substrate was used as the anode, which was placed in the electrolyte prepared in the previous step. The process parameters are: power frequency 100Hz, voltage 400V, duty cycle 20%, processing time 6min, and reaction temperature at room temperature;

[0052] 4) After the preparation of the titan...

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Abstract

The invention relates to the field of dental implant materials, and discloses a dental implant carrying miRNA (micro-ribonucleic acid) or siRNA (small interfering ribonucleic acid) and a preparation method thereof. The outer surface of the dental implant is a microarc oxidation coating with micro / nano appearance, wherein factors promoting osteogenic differentiation are loaded on the microarc oxidation coating, and are miRNA or siRNA. The preparation method comprises the following steps: processing pure titanium or titanium alloy into an implant matrix; polishing, cleaning and blow-drying; producing the microarc oxidation coating with micro / nano appearance on the outer surface of the implant matrix by adopting a microarc oxidation process, cleaning and blow-drying; mixing liposome and miRNA or siRNA to produce a carrier mixture; immersing the implant matrix into the carrier mixture, freezing with drikold; and loading the carrier mixture to the microarc oxidation coating by adopting a vacuum lyophilisation process, and standing at normal temperature to obtain the dental implant carrying miRNA or siRNA.

Description

technical field [0001] The invention relates to a dental implant material, in particular to a dental implant loaded with miRNA or siRNA and a preparation method thereof. Background technique [0002] With the development of implant technology, dental implants have been widely used in the restoration of clinical dentition defects and missing patients. However, after implant placement, osseointegration takes a long time. Generally speaking, implants can be repaired after 3-6 months. Especially for some special patients, such as diabetes and osteoporosis, it is more difficult to implement implants. Reluctant implants often lead to failure cases. This greatly perplexes patients and dentists. [0003] Nowadays, in order to increase the rate of osseointegration and shorten the time of osseointegration, various implant surface topography has appeared and been applied clinically, mainly using technologies such as Microarc Oxidation (MAO), titanium slurry spraying or sandblasting a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61C8/00A61K6/02A61K6/04C25D11/26
Inventor 张玉梅吴凯敏闫钧宋文
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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