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Isopropyl methyl phenol-containing liquid composition for oral cavity

A technology of propylmethylphenol and composition, which is applied in the field of liquid oral composition containing isopropylmethylphenol, can solve problems such as unresolved odor problems, and achieve good cooling feeling, excellent appearance stability, Odor reduction effect

Active Publication Date: 2012-07-11
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the problem of off-flavor originating from isopropylmethylphenol remains unsolved in these technologies

Method used

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  • Isopropyl methyl phenol-containing liquid composition for oral cavity
  • Isopropyl methyl phenol-containing liquid composition for oral cavity
  • Isopropyl methyl phenol-containing liquid composition for oral cavity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] The liquid oral compositions of the compositions shown in Tables 1 to 7 were prepared according to conventional methods, and the osmotic and bactericidal effects on model biofilms were evaluated by the following method. The results are shown in Tables 1-7.

[0101] In addition, in Examples 1 to 41 in Tables 1 to 3 and Examples 42 to 84 in Tables 5 to 7, the same results were obtained by substituting any of fragrance compositions B to I for fragrance composition A.

[0102] Evaluation method of model biofilm bactericidal effect:

[0103] Hydroxyapatite (HA) plates with a diameter of 7 mm were treated with human non-irritating saliva filtered through a 0.45 μm filter for 4 hours in tryptone soy broth supplemented with hemin and vitamin K3. 5 strains of Streptococcus mutans, Actinomyces naeslundii, Veillonella parvula, Fusobacterium nucleatum and Porphyromonas gingivalis The mixed strains were continuously cultured for 2 weeks to form a model biofilm on the HA plate. Af...

Embodiment 2

[0110] About the liquid oral cavity composition of the composition shown in Tables 1-7, external appearance stability and crystal precipitation were evaluated by the following method. The results are shown in Tables 1-7.

[0111] Appearance stability, crystal precipitation:

[0112] 450 mL of the samples shown in Tables 1 to 7 were filled into a PET container with a filling capacity of 450 mL, and the appearance stability and crystallization after storage in a constant temperature chamber at -5°C for 3 months were visually judged according to the following criteria precipitation.

[0113] Appearance Stability Evaluation Criteria

[0114] ⊚: Compared with the initial product, no change was observed.

[0115] ◯: There is no problem although very little dross is found.

[0116] Δ: Slight cloudiness was found.

[0117] ×: Considerable white turbidity or precipitates were found.

[0118] Crystal precipitation evaluation criteria

[0119] ⊚: There is no difference from th...

Embodiment 3

[0124] About the liquid oral composition of the composition shown in Tables 1-7, the feeling in use and the presence or absence of a bad smell were evaluated by the following method. The results are shown in Tables 1-7.

[0125] (1) Feeling of use

[0126] Put 20 mL of the samples shown in Tables 1 to 7 in the mouth, and after gargling for 30 seconds, evaluate the degree of cooling sensation, degree of irritation, and degree of stickiness immediately after rinsing in the following four stages. For each evaluation, the The average score of 10 people is shown in the table as ◎, ○, △, × according to the following criteria.

[0127] Cooling sensation after rinsing

[0128] 4: It is considered that there is a refreshing feeling.

[0129] 3: A slight refreshing feeling is considered.

[0130] 2: It is considered that there is a very slight cooling sensation.

[0131] 1: It is considered that there is no refreshing feeling.

[0132] with or without irritation after rinsing ...

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Abstract

Disclosed is a liquid composition for the oral cavity which contains isopropyl methyl phenol. The isopropyl methyl phenol-containing liquid composition for the oral cavity is contains (A) a nonionic surfactant, (B) a wetting agent selected from among glycerin, propylene glycol, polyethylene glycols and sorbitol, (C) 1-menthol, (D) a para-hydroxybenzoate and (E) a fragrance material selected from among 3-octanol, 3-octyl acetate, 3-octanone and fenchone. The total amount of component (B) contained in the composition is 5-20% by mass of the total mass of the composition, and substantially no ethanol is contained in the composition. The composition exhibits high penetration and high bactericidal effect on periodontal disease-causing biofilms, is free from the unpleasant taste caused by isopropyl methyl phenol, and has excellent feeling of use and good appearance stability.

Description

technical field [0001] The present invention relates to a liquid composition for oral cavity containing isopropylmethylphenol, which exhibits a high penetrating and sterilizing effect on periodontal pathogenic biofilms, has no odor derived from isopropylmethylphenol, and has a good refreshing feeling. Low irritation, no sticky feeling in the mouth, good feeling of use, and does not become cloudy or precipitate crystals over time when stored at low temperature, and has excellent stability over time. Background technique [0002] Isopropylmethylphenol is a nonionic bactericide that has attracted attention as a bactericidal agent having a high penetrating bactericidal effect on periodontal pathogenic biofilms. So far, there have been various proposals for oral compositions using isopropylmethylphenol (refer to Patent Document 1: Japanese Patent Laid-Open No. 62-24010, Patent Document 2: Japanese Patent Laid-Open No. 1-305021 , Patent Document 3: Japanese Patent Laid-Open No. 7...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/33A61K8/35A61K8/37A61K8/86A61K31/05A61K47/08A61K47/10A61K47/14A61K47/34A61P1/02A61P31/04A61Q11/00
CPCA61Q11/00A61K31/05A61K8/347A61P1/02A61P31/04
Inventor 石黑敬二平山隆池西岳树
Owner LION CORP
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