Tea polyphenol sodium alginate microsphere and preparation method and application thereof

A technology of sodium alginate and tea polyphenols, which is applied in the direction of pharmaceutical formulations, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve the problem of poor stability and the lack of stability of tea polyphenols Improvement of sexuality, low oral bioavailability and other issues

Inactive Publication Date: 2012-07-11
无锡纳诺生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these ingredients are prone to oxidation, polymerization, condensation and other reactions under conditions such as humidity, sunlight, and high temperature. The stability is very poor, and the oral bioavailability is particularly low. In addition, there are problems such as bitter taste, which limits the use of tea Application of phenol
It is also reported in the literature that sodium alginate-chitosan microspheres are used to encapsulate tea polyphenols, but the research results show that the content of tea polyphenols in the microspheres is relatively low. In addition, the stability of tea polyphenols has not been fundamentally affected. improve

Method used

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  • Tea polyphenol sodium alginate microsphere and preparation method and application thereof
  • Tea polyphenol sodium alginate microsphere and preparation method and application thereof
  • Tea polyphenol sodium alginate microsphere and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] [Example 1] One-step preparation of tea polyphenol sodium alginate-chitosan microspheres

[0041] Tea polyphenol sodium alginate-chitosan microspheres were prepared by one-step method in droplet method.

[0042] Preparation 1: Dissolve 100mg of tea polyphenols in 1wt% sodium alginate (molecular weight about 100,000, 60 mesh, viscosity 120mPa·s) aqueous solution, after degassing, then drop this solution at a certain speed into a solution containing 0.1M chlorine In the receiving solution of calcium chloride and 0.4wt% chitosan (molecular weight: 200,000), continue to stir for 1 hour, filter, collect microspheres, and freeze-dry for 24 hours to obtain tea polyphenol microspheres. According to the method for determining the content of tea polyphenols, the content of tea polyphenols in the microspheres was determined, and the drug loading and encapsulation efficiency were calculated.

[0043] Preparation 2: Dissolve and disperse 100mg of tea polyphenols and 20mg of porous ...

Embodiment 2

[0046] [Example 2] Two-step preparation of tea polyphenol sodium alginate-chitosan microspheres

[0047] Tea polyphenol sodium alginate-chitosan microspheres were prepared by two-step method in droplet method.

[0048] Preparation 3: 1wt% sodium alginate (molecular weight about 100,000, 60 mesh, viscosity 120mPa·s) aqueous solution is degassed, and then the solution is dropped at a certain speed into a solution containing 0.1M calcium chloride and 0.4wt% chitosan (molecular weight: 200,000), continue to stir for 1 h, and filter to obtain blank microspheres. Place the prepared blank microspheres in a 10 mg / ml tea polyphenol solution, absorb for 2 hours under slow stirring, collect the microspheres, freeze-dry for 24 hours, and obtain the tea polyphenol microspheres. According to the method for determining the content of tea polyphenols, the content of tea polyphenols in the microspheres was determined, and the drug loading and encapsulation efficiency were calculated.

[0049...

Embodiment 3

[0052] [Example 3] Stability test of tea polyphenol sodium alginate-chitosan microspheres

[0053] After placing tea polyphenol raw materials, preparation 1, preparation 2, preparation 3, and preparation 4 at room temperature for 2 months, it was found that tea polyphenols absorbed moisture after being placed for a few days, and the color turned red. Scanning with ultraviolet wavelengths showed that tea polyphenols It is oxidized to quinones to form dimers, and the maximum absorption peak is red-shifted. However, in preparations 1-4, the tea polyphenols were encapsulated in the microspheres, the color did not change significantly, and the maximum ultraviolet absorption wavelength did not change.

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Abstract

The invention relates to a tea polyphenol sodium alginate microsphere and a preparation method and an application thereof, in particular to a novel tea polyphenol sodium alginate microsphere. The microsphere is prepared from the following components in parts by weight: 4-6 parts of sodium alginate, 1-2 parts of chitosan, 1-2 parts of porous silicon dioxide and 3-6 parts of tea polyphenols. The porous silicon dioxide is added into a tea polyphenol microsphere, so that the content of tea polyphenols in the microphone can be increased remarkably. The preparation method of the tea polyphenol microsphere includes a liquid dripping one-step method and a liquid dripping two-step method. The microsphere disclosed by the invention can be widely applied in various fields of health-care products and biological medicine, and can be used for reducing blood fat, treating adiposity, removing free radicals in an anti-oxidation way, and preventing and treating tumors.

Description

technical field [0001] The invention relates to a microsphere, in particular to a tea polyphenol microsphere and its preparation method and application. Background technique [0002] Sodium alginate is the sodium salt of alginic acid. Alginic acid is a natural polysaccharide extracted from marine plant brown algae. It is composed of α-L-guluronic acid (M group) and its stereoisomer β- It is an unbranched linear block copolymer formed by two structural units of D-mannuronic acid (G group) linked by α(1-4) glycosidic bonds. Sodium alginate is an odorless and tasteless white powder with hygroscopicity. It can swell in the presence of water to form a viscous colloidal solution, insoluble in ethanol and other organic solvents. Its viscosity varies with the degree of polymerization, concentration and pH value. The material is stable, non-toxic, biocompatible and biodegradable [1-2] . A very important property of sodium alginate is that it can form gels with divalent cations o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K9/16A61K47/04A61K47/36A61P3/06A61P9/12A61P29/00A61P35/00A61P39/06
Inventor 马会利李利鹏
Owner 无锡纳诺生物科技有限公司
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