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Preparation method of high-strength biological glass bone bracket with regular-hole distribution

A bioglass and pore distribution technology, applied in the field of bioengineering, can solve the problems of insufficient scaffold biological activity, inability to adapt to rapid prototyping, and insufficient compressive strength, and achieve high compressive strength, good biological activity, and good biological Compatibility effect

Inactive Publication Date: 2012-07-04
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for preparing a high-strength bioglass bone scaffold with regular pore distribution, which solves the problem that the slurry cannot be adapted to rapid prototyping, and the bioactivity of the scaffold prepared by the traditional method is not high enough, or the compressive strength is not enough high disadvantage

Method used

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  • Preparation method of high-strength biological glass bone bracket with regular-hole distribution
  • Preparation method of high-strength biological glass bone bracket with regular-hole distribution
  • Preparation method of high-strength biological glass bone bracket with regular-hole distribution

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Example 1: The preparation of the three-dimensional connected scaffold consists of the following five steps.

[0029] (1) Preparation of glass powder

[0030]Weigh and weigh 3.8185g anhydrous sodium carbonate, 9.9587g anhydrous potassium carbonate, 1.7502g basic magnesium carbonate, 19.8328g calcium carbonate, 7.9781g strontium carbonate, 9.7420g silicon dioxide, 41.2991g boric acid, 5.6206g dihydrogen phosphate sodium. After uniform mixing and grinding, the ingredients were placed in a platinum crucible and kept at 1200°C for 30 min; then the obtained glass liquid was poured on a steel plate and quenched to obtain a glass block. The obtained glass blocks are coarsely crushed by a horizontal ball mill, finely crushed by a ball mill and sieved to obtain glass powder with a final particle size of 0.05-5 μm.

[0031] (2) Preparation of propylene glycol block polyether organic compound solution and determination of phase transition temperature

[0032] Take 50ml of tol...

Embodiment 2

[0041] Example 2: Determination of the pore size, porosity and strength of the scaffold

[0042] According to the method described in Example 1, a three-dimensional connected scaffold was prepared. Referring to the national standard GBT 5164-1985 "Determination of Porosity of Permeable Sintered Metal Materials", the porosity of the scaffold was measured, and the results showed that the porosity of the scaffold was 60%, and the maximum pore size was 400 μm, which was comparable to that of figure 1 SEM observations of B and C are consistent. Utilize the compressive strength tester to measure the support compressive strength in embodiment 1 to be 30MPa (see image 3 ).

Embodiment 3

[0043] Embodiment 3: the mensuration of biological property:

[0044] According to the method described in Example 1, a three-dimensional connected scaffold was prepared. The bioactivity, biodegradability and biocompatibility tests were carried out on the prepared scaffold.

[0045] Make XRD analysis to the support that makes, and compare with glass powder (see Figure 4 ), indicating that after a series of thermal processing, the obtained scaffold is still in the glass phase. Then the stent was soaked in a physiological simulation solution at a temperature of 37°C. After 20 days, the stent was taken out, and the reaction process and post-reaction products were characterized by XRD and FTIR (see Figure 5 , and 6), the XRD spectrum of the product shows a typical hydroxyapatite crystal spectrum, and the FTIR spectrum of the product shows a typical hydroxyapatite infrared spectrum. The results show that the borate glass bioactive scaffold sample can be converted into strontiu...

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Abstract

The invention belongs to the technical field of the bioengineering, and particularly relates to a preparation method of a high-strength biological glass bone bracket with regular-hole distribution. The preparation method of the glass bracket with bioactivity and capability for complete degradation comprises the following steps of: using a fusion method to prepare borate bioactive glass, and crushing and sieving glass blocks into glass powder with certain size; mixing the glass powder body with organic mixed liquid propylene-glycol block polyether solution into uniform slurry; by the three-dimensional printing process of a computer, printing a bracket precursor (blank body) under a designed program; and after the blank body is dried, sintering the blank body under high temperature, and finally obtaining the glass bracket with excellent bioactivity.

Description

technical field [0001] The invention belongs to the technical field of bioengineering, and in particular relates to a preparation method of a high-strength biological glass bone bracket with regular hole distribution. Background technique [0002] As a temporary structure for the growth of cells, the scaffold is a place that can induce cell differentiation and regenerate tissues and organs similar to the shape of the scaffold, and plays an important role in bone tissue engineering. The biggest feature of bone tissue is that the intercellular matrix has a large amount of calcium salt deposition, forming one of the hardest tissues in the human body. Structurally, hydroxyapatite can be regarded as a compressed material. For scaffold materials in bone tissue engineering, the primary requirement is the mechanical properties, that is, the mechanical properties of the scaffold must match those of the environmental tissue: low-strength scaffolds are not enough to support the daily a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/56A61L27/50
Inventor 黄文旵陆林楠王德平周萘崔旭李乐
Owner TONGJI UNIV
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