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Mesoporous polycaprolactone modified by natural high polymer and application thereof

A technology of natural polymer and polycaprolactone, applied in medical science, prosthesis, etc., can solve the problems of short modification time, low modification degree, difficult to achieve sustained release, etc.

Inactive Publication Date: 2012-06-27
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, natural polymer coatings are mostly used to directly coat the surface of polyester stents, but the modified products obtained have a low degree of modification and a short modification time (it will quickly dissolve in water and penetrate out of the stent), and the introduced drugs are also difficult to obtain. Will be released quickly, it is difficult to play a sustained release role

Method used

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  • Mesoporous polycaprolactone modified by natural high polymer and application thereof
  • Mesoporous polycaprolactone modified by natural high polymer and application thereof
  • Mesoporous polycaprolactone modified by natural high polymer and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] (1) Polycaprolactone (weight average molecular weight is 50,000~120,000) is dissolved in dioxane, the concentration is 0.2g / ml, and it is fully dissolved at 40℃ to obtain a clear solution, which is poured into the mold; Sodium chloride particles with a particle diameter of 200-300μm and sodium bicarbonate particles with a particle diameter of 45-50μm are mixed in a ratio of 6.5:3.5, respectively, to obtain an inorganic particle mixture, with a 10:1 inorganic particle mixture / polymer mass ratio Add to the above clear solution, stir and ultrasonic to make the inorganic particles uniformly dispersed in the polymer solution, then place it in a refrigerator at -20°C and freeze overnight. After taking it out, place it in 200 mL of anhydrous ethanol solution pre-frozen at -20℃~-18℃ overnight. After taking it out, place it in an aqueous hydrochloric acid solution with a pH of 5. Take it out after 24 hours and then immerse it in "double distilled water" , Change the water every 1...

Embodiment 2

[0049] Except that the drug indomethacin and bovine serum albumin were added to the gelatin / genipin solution, the gelatin concentration was 4w / v%, the bath temperature was 37°C, and the immersion time was 25 minutes, other conditions were the same as in Example 1. Repeat implementation 1. A step of.

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Abstract

The invention relates to a mesoporous-structure polycaprolactone modified by a natural high polymer and application thereof. The mesoporous-structure polycaprolactone modified by the natural high polymer has the advantages of high modification degree, a modifying object has small possibility of dissolving out and the like. In addition, the polycaprolactone provided by the invention also has a medicine slow-release function, and lays a foundation for the polycaprolactone to become a medicine-carrying functionalization tissue engineering support.

Description

Technical field [0001] The present invention relates to a polycaprolactone with a mesoporous structure and its use, in particular, to a polycaprolactone with a mesoporous structure modified by natural polymers and its use. Background technique [0002] As one of the three elements of tissue engineering, tissue engineering scaffolds can not only simulate the extracellular environment, induce cell adhesion, growth, and differentiation, but also serve as physical supports to compensate for mechanical losses caused by tissue defects. Polyester materials have biodegradability, good biocompatibility and excellent mechanical properties. They are widely used in the preparation of scaffolds (such as: the repair of bone, cartilage, skin, liver and other tissues). Ester stent). [0003] By introducing drugs or biologically active factors into the polyester stent system, the functionalization of this type of stent can be realized. For example, the introduction of anti-inflammatory drugs into...

Claims

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Application Information

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IPC IPC(8): C08L67/04C08L89/00C08L5/08C08J3/24A61L27/22A61L27/24A61L27/20A61L27/56
Inventor 郎美东张清淳
Owner EAST CHINA UNIV OF SCI & TECH
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