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Separate type water suspension medicine comprising fluticasone propionate and adjuvant-containing water and used for treating skin diseases

A technology for fluticasone propionate and dermatology, applied in the fields of skin diseases, drug combinations, organic active ingredients, etc., can solve the problems of unstable particles and inability to ensure long-term storage of particulate suspensions, reduce waste and ensure stable suspension. Sexual, easy-to-use effects

Inactive Publication Date: 2012-05-30
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] How to solve the problem of particle instability in microparticle suspensions has always been one of the problems that need to be solved in pharmacy, but whether by adding excipients or improving the particle structure, it is impossible to ensure long-term preservation of microparticle suspensions, especially for skin products. Suspensions are multi-use and are more likely to have the above problems

Method used

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  • Separate type water suspension medicine comprising fluticasone propionate and adjuvant-containing water and used for treating skin diseases
  • Separate type water suspension medicine comprising fluticasone propionate and adjuvant-containing water and used for treating skin diseases
  • Separate type water suspension medicine comprising fluticasone propionate and adjuvant-containing water and used for treating skin diseases

Examples

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preparation example Construction

[0028] 1. Preparation of transdermal drug particles

[0029] The subpackaged capsules of the pharmaceutical particles obtained in Examples 1 to 10 are vegetable capsules, and the subpackaged capsules are packaged with aluminum foil blister packs.

Embodiment 1

[0031] Dissolve 0.2 g of fluticasone propionate in ethanol, filter, spray-dried the filtrate, micronize to make the particle size reach 3 μm, pass through a 200-mesh sieve for 3 times, mix well, sterilize, and divide into No. 3 capsules. Fluticasone acid 2 mg. Electron microscope observation of the particles is spherical.

[0032] The process conditions are: the inlet temperature is 105 °C, the outlet temperature is 68 °C, the air flow rate is 90%, the inner diameter of the nozzle outlet is 0.1 cm, the air flow rate of the nozzle is 800 ml / min, and the injection rate is 50 mL / h.

Embodiment 2

[0034] Dissolve 1 g of fluticasone propionate in ethanol, filter, spray-dried the filtrate, micronize it to a particle size of 3 μm, mix it three times with a 200-mesh sieve, sterilize it, and pack it into No. 3 capsules. Fluticasone acid 1mg. Electron microscope observation of the particles is spherical.

[0035] The process conditions are as follows: inlet temperature is 105°C, outlet temperature is 70°C, air flow rate is 90%, nozzle outlet inner diameter is 0.1cm, nozzle air flow rate is 800ml / min, and injection rate is 50mL / h.

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Abstract

The invention relates to a separate type water suspension medicine comprising fluticasone propionate and adjuvant-containing water and used for treating skin diseases, which comprises separately packed fluticasone propionate of D90 particle size 0.1-10 mum and separately packed water containing one or more adjuvants for dermatologic medicine. The separately packed insoluble dermatologic medicine has a preferably D90 particle size of 1-10 mum, and a particle shape of a sphere or a spheroid.

Description

Technical field: [0001] The invention relates to a drug for skin, which is composed of water-insoluble fluticasone propionate packaged separately and water containing one or more skin-use pharmaceutical excipients packaged separately. Background technique: [0002] Skin inflammation such as eczema (eczema), allergic dermatitis (allergic dermatitis), atopic dermatitis (atopic dermatitis), urticaria (Urticaria), etc. are caused by allergic reactions caused by certain allergens and cause skin inflammation. [0003] In the skin drug delivery system, the skin is the main barrier for drugs to enter the body. Studies have found that only a few drugs have excellent skin permeability, and most drugs are not easy to pass through the effective and selective barrier of human skin. Drugs that are more soluble cross the epidermis more easily. For the treatment of skin diseases, the most common type of preparation is transdermal drug delivery, transdermal drug delivery system or transderm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61K9/10A61P17/00A61P17/08A61P37/08
Inventor 孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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