Oral composition containing desmopressin acetate and preparation method for oral composition

A technique for desmopressin and its composition, which is applied in the field of oral composition containing desmopressin acetate and its preparation, to achieve the effect of stable and long-lasting onset, reduced medication times, and low toxicity

Inactive Publication Date: 2014-08-06
赵联华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Desmopressin acetate is a peptide compound. In order to avoid being destroyed by gastrointestinal enzymes, oral tablets prepared according to the prior art often increase the dosage of desmopressin acetate, which is still easy to cause pressurized side effects, therefore, the oral composition containing desmopressin acetate which is easy to develop and use, simple in preparation process and low in side effects is the problem to be solved by the present invention

Method used

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  • Oral composition containing desmopressin acetate and preparation method for oral composition
  • Oral composition containing desmopressin acetate and preparation method for oral composition

Examples

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Effect test

Embodiment 1

[0064] The preparation method of the composition containing lactose and cellulose: 10g alpha lactose, add 50g water, stir to dissolve at 90°C, cool to 40°C, filter, add 10g 20μm hydroxymethylpropyl cellulose (HPMC) to the filtrate ), stirring, crystallizing at 20°C, suction filtration to remove the mother liquor, washing with 1°C distilled water, vacuum drying, and crushing.

Embodiment 2

[0066] The preparation method of the composition containing lactose and cellulose: 10g beta lactose, add 50g water, stir to dissolve at 90°C, cool to 40°C, filter, add 10g 10μm hydroxymethylpropyl cellulose (HPMC) to the filtrate ), stir, crystallize at 20°C, remove the mother liquor by suction filtration, wash with 3°C distilled water, vacuum dry, and crush.

Embodiment 3

[0068] The preparation method of the composition containing lactose and cellulose: 10g amorphous lactose, add 50g water, stir to dissolve at 90°C, cool to 40°C, filter, add 10g 25μm microcrystalline cellulose (MCC) to the filtrate, Stir, crystallize at 20°C, remove the mother liquor by suction filtration, wash with distilled water at 5°C, vacuum dry, and crush.

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Abstract

The invention discloses an oral composition containing desmopressin acetate and a preparation method for the oral composition. The oral composition comprises a composition containing the desmopressin acetate, polymer excipients and a surfactant, a composition containing lactose and cellulose, a diluent, a solubilizer, a penetration enhancer, a flavoring agent, an antioxidant and a lubricant. The oral composition containing the desmopressin acetate has a stable and durable effect and a small side effect; and the oral composition is applicable to oral formulations such as tablets, capsules, pellets and the like. The oral composition has a good effect of treating diseases such as enuresis, nocturia, diabetes insipidus and the like.

Description

Technical field [0001] The invention belongs to the field of pharmaceutical preparations, and specifically relates to an oral composition containing desmopressin acetate and a preparation method thereof. Background technique [0002] Insufficient vasopressin causes the kidneys to produce a large volume of very dilute urine, which can cause severe dehydration. Desmopressin (1-deamino-8-D-arginine vasopressin, dDAVP) is an analog of vasopressin, a nonapeptide, which is a result of two changes in the chemical structure of natural hormones The result is that 1-cysteine ​​is de-amino and 8-D-arginine is substituted for 8-L-arginine. After these structural changes, the clinical dose of desmopressin acetate has a longer action time without the side effects of compression. Used to treat central diabetes insipidus. After taking DDAVP, it can reduce urine excretion, increase urine osmotic pressure, and reduce plasma osmotic pressure, thereby reducing frequent urination and nocturia; it ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/11A61P7/12A61P13/00A61K38/095
Inventor 赵联华
Owner 赵联华
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