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Toad-cortex ultra-micro powder soft capsule and preparation method thereof

A technology for soft capsules and toad powder, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, and can solve problems such as poor water solubility and unsatisfactory bioavailability.

Inactive Publication Date: 2012-03-21
杨鸣泽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current superfine powder of toad clothing is prepared as hard capsules, but it is found in the research that the superfine powder of toad clothing has obvious pungent taste, and its water solubility is poor. reach the ideal state

Method used

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  • Toad-cortex ultra-micro powder soft capsule and preparation method thereof
  • Toad-cortex ultra-micro powder soft capsule and preparation method thereof
  • Toad-cortex ultra-micro powder soft capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: Soft Capsule Stability Research

[0011] Prepare soft capsule 1, soft capsule 2 and soft capsule 3 according to the content formulas 1, 2 and 3, and take different soft capsule samples to conduct temperature, humidity and strong light exposure influencing factors according to the Chinese Pharmacopoeia "Guiding Principles for Drug Stability Test" . The humidity condition is 92.5%, the light condition is 4500Lx, and the temperature condition is 40°C, and the selected indicators, the disintegration time limit and the content of toad clothing superfine powder are investigated.

[0012] Experimental results of influencing factors of soft capsules

[0013]

[0014] The results showed that the capsules prepared with soybean oil as oily base were placed for 15 days under the conditions of the above-mentioned influencing factors, and their properties, disintegration time limit and content did not change significantly compared with those before placement, and th...

Embodiment 2

[0015] Embodiment 2: Observation of curative effect of soft capsule and hard capsule in treating 321 cases of advanced malignant tumors

[0016] 1. General information of the case

[0017] The 321 patients in this group were all hospitalized patients, all of whom were diagnosed as advanced malignant tumors by histopathological CT examination. Among them, there were 33 cases of liver cancer, 39 cases of lung cancer, 24 cases of breast cancer, 18 cases of esophageal cancer, 24 cases of gastric cancer, 12 cases of nasopharyngeal cancer, 24 cases of ovarian cancer, 24 cases of bladder cancer, 36 cases of rectal cancer, 12 cases of skin cancer, There were 39 cases of carcinoma, 18 cases of spout carcinoma, and 18 cases of brain glioma. They were randomly divided into treatment group 1, treatment group 2 and control group, 107 cases each. Among the 214 cases in the treatment group, there were 110 males and 104 females; the oldest was 78 years old, the youngest was 22 years old, an...

Embodiment 4

[0028] Embodiment 4: typical case

[0029] 4.1 Liver cancer patient: Chen Moumou, male, 46 years old, from Nantong City, Jiangsu Province

[0030] In February 2010, the patient felt pain in the liver. Accompanied by my family, I went to Nantong Hospital of Traditional Chinese Medicine for examination on March 6. CT showed malignant liver tumors, liver masses 10.8×8.8CM, 7.7×6.8CM multiple massive tumors, AFP greater than 1000, the hospital suggested intervention treatment solutions. Due to the poor economic conditions of the patient's family, interventional therapy could not be performed. On March 16th, the patient began to take 5 capsules of superfine powder hard capsules of Chanyi every day 4 times a day, each 0.2 gram. After taking it for 10 days, he felt full of stomach, and then changed his clothes to soft capsules of superfine powder of Chanyi of the present invention. 4 times a day, try to take 5 Chanyi superfine powder soft capsules each time, 0.2 grams per capsule,...

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Abstract

The invention relates to a soft capsule containing toad-cortex, and the capsule takes soybean oil as an oleaginous base, so that the stability and the bioavailability of the capsule are improved significantly. The toad-cortex ultra-micro powder soft capsule is used for treating cancers, wherein the cancers are solid tumors, preferably liver cancers, lung cancers, breast cancers, esophagus cancers, stomach cancers, nasopharyngeal cancers, ovarian cancers, rectal cancers, uterine cancers, cardiac cancers, gliomas and other cancers, and more preferably liver cancers, lung cancers, breast cancers, esophagus cancers, stomach cancers, rectal cancers, uterine cancers and cardiac cancers, and the effects for terminal cancer patients with gastrectasia and vomit are particularly obvious. The toad-cortex ultra-micro powder soft capsule can not only show the amazing treatment effect for diseases-tumors perplexing human beings, but also utilize the toad-cortex based on the natural exuviation phenomenon of toads, thereby not only effectively utilizing resources, but also protecting the ecological environment.

Description

technical field [0001] The invention relates to a soft capsule and a preparation method thereof, in particular to a soft capsule of toad-yi superfine powder and a preparation method thereof. Background technique [0002] The toad coat is the cuticle membrane of the toad. The toad has a certain growth pattern. Except for the hibernation period, the cuticle is naturally shed once every 7-10 days. This kind of cuticle is commonly known as the toad coat. Colorless transparent secretion. Studies in recent years have shown that toad clothing has excellent medicinal value, such as clearing away heat, detoxifying, reducing swelling, improving the body's immunity, killing cancer cells and virus cells, etc. The anti-tumor effects of lung cancer, S180 sarcoma, and H22 liver cancer solid tumors are about 50%, and at the maximum solubility and maximum volume, 16 grams of superfine powder per kilogram of mice per day have no adverse reactions. The current superfine powder of toad clothi...

Claims

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Application Information

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IPC IPC(8): A61K35/56A61K47/44A61K9/48A61P35/00A61K35/65
Inventor 杨鸣泽缪细泉缪珠雷杨俊杰
Owner 杨鸣泽
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