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Chinese medicinal preparation with effects of protecting intestines and removing toxic materials, and preparation method thereof

A traditional Chinese medicine preparation and detoxification technology, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, antibacterial drugs, etc., can solve the problems of high cost and poor curative effect, reduce damage, eliminate intestinal toxins, protect The effect of the intestinal barrier

Active Publication Date: 2013-06-05
THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are a variety of drugs for the treatment of intestinal-derived endotoxin in the prior art, but most of them have defects such as poor curative effect and high cost

Method used

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  • Chinese medicinal preparation with effects of protecting intestines and removing toxic materials, and preparation method thereof
  • Chinese medicinal preparation with effects of protecting intestines and removing toxic materials, and preparation method thereof
  • Chinese medicinal preparation with effects of protecting intestines and removing toxic materials, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Research on the dosage form of traditional Chinese medicine preparations with the effect of protecting the intestines and detoxifying

[0019] 1. Screening of extraction process

[0020] In this experiment, on the basis of single factor investigation, three factors that have a significant impact on the extraction process were selected: extraction times, water addition, and extraction time as the main influencing factors. The comprehensive evaluation of the content and the extraction rate of the drug is used as the evaluation index, and the orthogonal experimental design method is used to optimize the extraction process, extract the main active ingredients of the drug to the maximum extent, and provide high-quality raw materials for the preparation of pellets.

[0021] 1. Instruments and reagents:

[0022] 1.1 Instrument

[0023] High-performance liquid chromatography (model: LC-10AT, SPD-10A ultraviolet detector; serial number: C20974030587CS; manufacturer: ...

Embodiment 2

[0076] Embodiment 2 prepares the traditional Chinese medicine preparation with effect of protecting intestines and detoxifying

[0077] The formula is: rhubarb 9g, comfrey 9g, poria cocos 30g, coix seed 30g, white and 15g, red peony 24g, scutellaria baicalensis 15g, andrographis paniculata 12g, catechu 9g, licorice 3g.

[0078] The preparation method is as follows: weigh each raw material, put it into an extraction bag, first add 8 times the amount of water to soak for 1 hour, then decoct and extract 3 times, add 8 times the amount of water each time, extract for 2 hours each time, combine the extracts, and concentrate to The relative density is 1.05, and it can be obtained by spray drying.

Embodiment 3

[0079] Embodiment 3 prepares the traditional Chinese medicine preparation with effect of protecting intestines and detoxifying

[0080] The formula is: rhubarb 9g, comfrey 9g, poria cocos 30g, coix seed 30g, white and 15g, red peony 24g, scutellaria baicalensis 15g, andrographis paniculata 12g, catechu 9g, licorice 3g.

[0081] The preparation method is as follows: mixing the raw materials, adding 4 times the amount of water, heating until the water boils, decocting with low heat for 30 minutes, and filtering to obtain the filtrate.

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Abstract

The invention discloses a Chinese medicinal preparation with effects of protecting intestines and removing toxic materials. The Chinese medicinal preparation comprises the following Chinese herbal medicines in part by weight: 6 to 12 parts of rhubarb, 6 to 12 parts of sinkiang arnebia root, 25 to 35 parts of tuckahoe, 25 to 35 parts of coix seed, 10 to 20 parts of common bletilla pseudobulb, 20 to 30 parts of red paeony root, 10 to 20 parts of scutellaria baicalensis, 10 to 15 parts of common andrographis herb, 6 to 12 parts of cutch, and 2 to 5 parts of liquorice. A preparation method comprises the following steps of: weighing Chinese herbal medicines, loading into an extraction bag, adding water in an amount which is 8 to 12 times weight of the Chinese herbal medicines, soaking for 1 to2 hours, decocting and extracting for 1 to 2 hours, filtering to obtain an extracting solution, concentrating until the relative density is 1.02 to 1.05, and spraying and drying to obtain the Chinesemedicinal preparation. The Chinese medicinal preparation has the effects of protecting intestine barriers, removing toxin in intestines, reducing cell factors, and reducing damage of other inflammatory mediators to liver.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation with the effect of protecting the intestines and detoxifying and a preparation method thereof. Background technique [0002] my country is a highly prevalent area of ​​hepatitis B virus (Hepatitis B Virus, HBV) infection, the positive rate of hepatitis B surface antigen (HBsAg) is 9.09%, about 120 million people, of which about 30 million people are chronic hepatitis B patients. A large number of data confirm that most chronic liver diseases are accompanied by intestinal endotoxemia (Intestinal Endotoxemia, IETM). The incidences of IETM in patients with severe hepatitis, hepatitis cirrhosis, chronic hepatitis and acute hepatitis were 93.3%, 84.3%, 79.0% and 75.0%, respectively. The pathogenesis and progression of chronic hepatitis B liver disease, the role of intestinal endotoxemia has been paid more and more attention. Endotoxin and endotoxin activate the cascade chain release of Kup...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8994A61P1/00A61P1/16A61P31/04
Inventor 李勇孙欢娜胡冬青
Owner THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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