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Biomimetic polymer, and preparation method and application thereof

A technology of copolymer and imitating cell outer layer membrane, which is applied in the field of (meth)acrylate copolymer, biomimetic copolymer and its preparation, can solve the problems of unstable coating and unsatisfactory material modification effect, and achieves the The effect of easy storage, excellent stability and biocompatibility, and broad application prospects

Inactive Publication Date: 2012-02-15
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Still another object of the present invention is to provide the application of the above-mentioned biomimetic copolymer in the preparation of the imitation cell outer layer membrane structure coating, to solve the instability of the usual polymer coating containing flexible chains and the formation of anti-imitation cell membrane structure resulting in material modification Problems with unsatisfactory sexual performance

Method used

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  • Biomimetic polymer, and preparation method and application thereof
  • Biomimetic polymer, and preparation method and application thereof
  • Biomimetic polymer, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Embodiment 1 The preparation of the copolymer PMC64 containing phosphorylcholine group and cholesterol hydrophobic side group

[0037] in dry N 2 Under protection, add 10mL of a dry mixture of ethanol and tetrahydrofuran (1 / 1, v / v) to a 100mL three-necked flask, add a condenser tube and a calcium chloride drying tube, heat the oil bath to 70°C, and the molar percentage is 60 :40 Weigh MPC and cholesterol methacrylate (CholMA), dissolve them in 30 mL ethanol and tetrahydrofuran respectively, and mix well. After the initiator AIBN of 2.0wt% (accounting for the percentage of total monomer mass) is dissolved with 6mL anhydrous tetrahydrofuran, wherein 2mL is added in the three-necked bottle, 3mL is added in the monomer mixture, after the temperature stabilizes, use it under electromagnetic stirring The constant pressure dropping funnel drips the mixture of monomer and initiator into the three-neck bottle, and controls the dropping speed. After 3-4 hours, stop the N 2 , s...

Embodiment 2

[0039] Weigh methacryloyloxytetraethylene glycol-based phosphorylcholine and 10-cholesteryloxydecyl methacrylate at a molar percentage of 30:70, dissolve them in 30 mL of isopropanol and 50 mL of tetrahydrofuran, and mix well. After the initiator AIBN of 0.5wt% (accounting for the percentage of total monomer mass) is dissolved with 6mL anhydrous tetrahydrofuran, wherein 1.5mL is added in the three-necked bottle, 3.5mL is added in the monomer mixture, after the temperature stabilizes, under electromagnetic stirring Use a constant pressure dropping funnel to drop the mixture of monomer and initiator into the three-necked bottle, control the dropping speed, finish dropping in 3-4 hours, stop the N after dropping 2 , sealed, and after the system continued to react for 4 hours, the remaining 1 mL of AIBN in anhydrous tetrahydrofuran solution was added, and the reaction was stopped after 24 hours. Concentrate the reaction liquid to 15-20mL, use dialysis method (the molecular weight ...

Embodiment 3

[0041] Take MPC and cholesteryloxyethylene glycol methacrylate by molar percentage 80:20, mix with 60mL isopropanol and 30 THF respectively after dissolving, the initiator AIBN of 5.0wt% (accounting for the percentage of total monomer mass) After dissolving with 6mL of anhydrous tetrahydrofuran, add 0.5mL into the three-neck flask, and add 4mL into the monomer mixture. After the temperature is stable, use a constant pressure dropping funnel to drop the monomer into the three-neck flask under electromagnetic stirring and trigger The mixed solution of the agent, control the dropping speed, finish dropping in 3-4h, stop N after dropping 2 , sealed, and the system continued to react for 4 hours, and then added 1.5 mL of AIBN in anhydrous tetrahydrofuran solution, and the reaction was stopped after 24 hours. Concentrate the reaction liquid to 15-20mL, use dialysis method (the molecular weight cut-off of the dialysis bag is 6000-7000D) to purify the crude product, freeze-dry and use...

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Abstract

The invention discloses a copolymer shown as a structure general formula (I). In the formula, x and y are integers between 10 and 1,000, the molar content of x is 30 to 80 percent, and the molar content of y is 20 to 70 percent; R1 and R2 are H or CH3; W is a hydrophilic group connected with 2 to 8 carbon atom chains, and the hydrophilic group is a phosphorylcholine group, a carboxylic acid betaine group, a sulfobetaine group, a quaternary ammonium group or a sulfonic acid group; and Z is a hydrophobic rigid group connected with 0 to 12 carbon atom chains, and the hydrophobic rigid group is a cholesterol group, a dihydrocholesterol group, a beta-sitosterol group, a stigmasterol group, a 7-dehydrocholesterol group or an ergot sitosterol group. The minimum content of hydrophilic groups such as phosphorylcholine and the like in the polymer is 30 percent; and the coating prepared by the method has high surface coverage rate of hydrophilic groups as well as good hydrophilic nature and high biocompatibility, and can be widely applied to the hydrophilic treatment of the surfaces of materials and the biocompatibility modification of the surfaces of biomedical materials.

Description

technical field [0001] The invention relates to a biomimetic copolymer capable of forming a stable imitation cell membrane structure and a preparation method thereof, in particular to a (meth)acrylate copolymer capable of forming a stable cell outer membrane structure, and the biomimetic copolymer can be used to prepare cell imitation The outer film structure coating belongs to the technical fields of polymer chemistry and physics, surface science and biomedical materials. Background technique [0002] Phosphorylcholine is the hydrophilic end group that constitutes the basic unit of the outer membrane structure of biological cells. Amphiphilic copolymers containing phosphorylcholine groups are used to construct a hydrophilic coating on the surface of the material. When it contacts with water The surface can form a surface imitating a cell membrane structure. This zwitterionic structure surface is conducive to maintaining the conformation of biomolecules in contact with it, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/36C08F220/40C08J5/18
Inventor 史素青张琴王彦兵党媛宫永宽
Owner NORTHWEST UNIV
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