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Sulfanilamide medicament composition for wound surface

A technology of sulfonamide drugs and compositions, applied in the field of pharmaceutical compositions, can solve the problems of high skin irritation, antifreeze, unsatisfactory stability effect, etc., achieve strong bacteriostatic effect, shorten wound healing days, and shorten treatment period. Effect

Active Publication Date: 2012-02-15
CHENGDU FIRST PHARMACEDTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent application 01107197.4 (publication number CN1312078A) discloses a kind of manufacture method of compound zinc sulfadiazine coating agent, this coating agent contains the composition of calcium salt and preservative, but antifreeze, stability effect is not ideal enough
Chinese patent application 02160214.X (publication number CN1513458A) discloses a kind of compound sulfadiazine silver-zinc ointment and preparation method thereof, but skin irritation is large

Method used

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  • Sulfanilamide medicament composition for wound surface
  • Sulfanilamide medicament composition for wound surface
  • Sulfanilamide medicament composition for wound surface

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Preparation of samples 1-6

[0035] Heat 750g of distilled water to boiling, slowly add 50g of sodium alginate under stirring, continue to boil and dissolve in a boiling water bath until it becomes a uniform paste, add sulfadiazine zinc, sulfadiazine silver, laurocaprazine and other components under stirring, Stir well, continue to boil for 10 minutes, weigh, add water to make up 1000g, cool to room temperature, and grind three times with a colloid mill to obtain a sample. The dosages of zinc sulfadiazine, silver sulfadiazine and laurocaprazine in each sample are as follows:

[0036] Sample 1: Zinc sulfadiazine (dihydrate) 20g Silver sulfadiazine 10g Laurocaprazine 2g

[0037] Sample 2: Zinc sulfadiazine (dihydrate) 20g Silver sulfadiazine 10g Laurocaprazine 0.45g

[0038] Sample 3: sulfadiazine zinc (anhydrous substance) 20g sulfadiazine silver 10g laurocapram 0.2g

[0039] Sample 4: Zinc sulfadiazine (dihydrate) 20g Silver sulfadiazine 10g Laurocaprazine 20g

[0040...

Embodiment 2

[0061] Sample 7: Weigh 20g of zinc sulfadiazine (dihydrate), 10g of silver sulfadiazine, 0.5g of laurocaprazine, 0.95g of niplatinum methyl ester, 0.4g of calcium gluconate, 68g of sodium alginate, 135g of glycerol, Appropriate amount of distilled water. Heat 750g of distilled water to boiling, slowly add sodium alginate while stirring, continue to boil and dissolve in a boiling water bath until it becomes a uniform paste, add zinc sulfadiazine, silver sulfadiazine and other components while stirring, stir well, and continue to boil Weigh after 10 minutes, add water to make up 1000g, cool to room temperature, and grind three times with a colloid mill to obtain a sample.

[0062] Sample 8: Weigh 20 g of zinc sulfadiazine (dihydrate), 10 g of silver sulfadiazine, 0.95 g of niplatinum methyl, 0.4 g of calcium gluconate, 68 g of sodium alginate, 135 g of glycerol, and an appropriate amount of distilled water. Heat 750g of distilled water to boiling, slowly add sodium alginate whi...

Embodiment 3

[0069] Sample 9: Weigh 8000g of zinc sulfadiazine (anhydrous), 4000g of silver sulfadiazine, 412g of laurocaprine, 1732g of ethyl niplatinate, 865g of calcium polyenoate, 8000g of gelatin, 5600g of glycerin, and an appropriate amount of distilled water. Heat an appropriate amount of distilled water to boiling, slowly add gelatin under stirring, continue to boil and dissolve in a boiling water bath until it becomes a uniform paste, add sulfadiazine zinc, sulfadiazine silver and other components under stirring, stir well, add water to make up the weight, Stir well, cool to room temperature, colloid milling twice, finally get 100000g sample.

[0070] Sample 10: Weigh 8000g of zinc sulfadiazine (anhydrous), 4000g of silver sulfadiazine, 1732g of ethyl niplatinate, 865g of calcium polyenoate, 8000g of gelatin, 5600g of glycerin, and an appropriate amount of distilled water. Heat an appropriate amount of distilled water to boiling, slowly add gelatin under stirring, continue to boil...

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Abstract

The invention discloses a sulfanilamide medicament composition for a wound surface. The medicament composition contains sulfadiazine zinc, sulfadiazine silver and laurocapram, and can further contain preservative and medicinal calcium salt. The medicament composition is prepared into clinically acceptable formulations such as gel, mucilage, film coating agent and the like according to a conventional process by adding medicinal auxiliary materials. The medicament composition has strong antibacterial and bacteriostatic effects, obviously shortens the healing time of the wound surface, has good pain easing effect, is safe, effective and convenient to use; and the composition has stable anti-freezing property.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, and in particular relates to a sulfonamide pharmaceutical composition, a preparation method thereof, and a pharmaceutical preparation prepared therefrom. Background technique [0002] Sulfadiazine silver (SD-Ag), the English name is Sulfadiazine Silver, the chemical name is N-2-pyrimidinyl-4-aminobenzenesulfonamide silver salt; the molecular formula is C 10 h 9 AgN 4 o 2 S, molecular weight: 357.14, chemical structural formula as follows: [0003] [0004] Silver sulfadiazine is white or off-white crystalline powder, which is easy to deteriorate when exposed to light or heat, and is insoluble in water, ethanol, chloroform or ether. [0005] Silver sulfadiazine has a strong inhibitory effect on the dominant burn bacteria Pseudomonas aeruginosa, and silver salt has astringent effect, which can make the burn wound dry, scab and heal early. [0006] Sulfadiazine zinc (SD-Zn), Englis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/635A61K47/22A61P31/04A61P17/02A61P3/02
Inventor 吴大蓉马建强
Owner CHENGDU FIRST PHARMACEDTICAL CO LTD
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