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Magnesium alloy/biological ceramic bone bracket based on photocuring and gel casting and forming method of bone bracket

A bioceramic, gel injection molding technology, applied in bone implants, medical science, prostheses, etc., can solve the problems of mismatching strength degradation rate and bone reconstruction process, insufficient mechanical strength and stability, etc. Insufficient mechanical strength and stability, the effect of reducing the contact area

Inactive Publication Date: 2014-01-29
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a magnesium alloy / bioceramic based on photocuring and gel injection molding to solve the problems of insufficient mechanical strength and stability in the early stage of bone scaffold implantation and the mismatch between the strength degradation rate and the bone reconstruction process. Bone scaffold and its forming method

Method used

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  • Magnesium alloy/biological ceramic bone bracket based on photocuring and gel casting and forming method of bone bracket
  • Magnesium alloy/biological ceramic bone bracket based on photocuring and gel casting and forming method of bone bracket
  • Magnesium alloy/biological ceramic bone bracket based on photocuring and gel casting and forming method of bone bracket

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Embodiment 1

[0021] see figure 1 , 1) Firstly, according to the specific situation of the patient's bone defect site, the shape correlation and microstructure bionic design of the bone defect site are carried out with the help of reverse engineering and CAD technology, and the force, internal deformation and hydrodynamic characteristics of the bracket are analyzed by CAE analysis software and structural modifications to form a CAD model of a biomimetic scaffold with a connected internal microstructure;

[0022] 2) Using layering software to layer the CAD model of the bionic bracket, the layer thickness is 0.10mm, and use the light curing molding machine to make the negative resin mold of the bracket according to the layered results;

[0023] Among them, the wavelength of the laser of the light curing molding machine is 355nm; the spot diameter is 0.2mm; the filling scanning speed is 5000mm / s; the filling vector spacing is 0.10mm; the supporting scanning speed is 2000mm / s; the jumping speed...

Embodiment 2

[0027] Embodiment 2: Ceramic slurry is prepared according to the following method in the present embodiment, and other steps are with embodiment 1:

[0028] Ceramic powder Alpha-tricalcium phosphate (α-TCP), water solvent deionized water, organic monomer methyl-acyloxyethyltrimethylammonium chloride, dispersant ammonium polyacrylate and crosslinking agent N, N- Diacetone acrylamide is mixed evenly at a mass ratio of 120:80:8:1:1, put into a vacuum machine to remove air bubbles, and adjust the pH of the mixture to 9 with concentrated ammonia water to obtain a slurry, and then add The initiator sodium persulfate with 0.5 times the weight of the crosslinking agent and the catalyst N,N-dimethylcyclohexylamine form a ceramic slurry.

Embodiment 3

[0029] Embodiment 3: Ceramic slurry is prepared according to the following method in the present embodiment, and other steps are with embodiment 1:

[0030] Ceramic powder apatite, water solvent deionized water, organic monomer adipate dihydrazide, dispersant sodium polyacrylate and cross-linking agent dibenzylidene acetonyl acrylamide according to the ratio of 115:60:7:1.5:1.5 The mass ratio is mixed evenly, put into a vacuum machine to remove air bubbles, and adjust with concentrated ammonia water to make the pH of the mixture = 9 to obtain a slurry, then add initiator potassium persulfate and catalyst N , N, N', N", N"-pentamethyldiethylenetriamine forms a ceramic slurry.

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Abstract

The invention discloses a magnesium alloy / biological ceramic bone bracket based on photocuring and gel casting and a forming method of the bone bracket. The method comprises the following steps of: establishing computer-aided design (CAD) models of the bracket and a bracket negative model through shape correlation and microstructure simulation by using reverse engineering and CAD according to the structures of different bone defect parts and the analysis results of biomechanics; making a resin bracket negative model by a photocuring technology; filling ceramic slurry into the bracket negative model by a gel casting process, curing and sintering at a high temperature to make a biological activity ceramic framework with mutually-communicated porous pipelines; and casting molten magnesium alloy into the porous pipelines of the biological activity ceramic framework by a vacuum suction casting method, cooling for solidification, and thus obtaining the magnesium alloy / biological ceramic simulation composite structure bone bracket. The internal microstructure of the made bracket consists of the mutually-communicated pipelines, the magnesium alloy is filled in the pipelines to increase the early mechanical property of the composite bracket, and the pipelines filled with the magnesium alloy become mutually-communicated pore passages as the magnesium alloy is corroded and degraded, so that the requirements of organization growth, nutrition and metabolism are met.

Description

technical field [0001] The invention belongs to the field of manufacturing engineering, in particular to a magnesium alloy / bioceramic bone support based on photocuring and gel injection molding and a forming method thereof. Background technique [0002] Large-area bone defects caused by trauma, tumors, congenital deformities and other factors are clinical problems. According to statistics, more than 2.2 million bone defect repair operations are performed every year in the world, and about 3.5 million patients with bone defects or bone injuries are diagnosed in my country every year. There are more than 15 million patients with limb disorders nationwide, of which 3 million amputations due to lack of reconstructive surgery and bone replacement materials. The total market for individual bone matching in my country is at least 50 million yuan each year. Bone tissue engineering provides a new idea for the permanent repair of bone defects. The construction of bone tissue engineer...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/50A61F2/28B22D19/00
CPCA61F2/28
Inventor 李涤尘闫元媛连芩靳忠民刘亚雄贺健康
Owner XI AN JIAOTONG UNIV
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