Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Adrenal cortical hormone compound preparation

A technology of adrenal cortex and compound preparations, which is applied in the direction of anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., to achieve the effect of sufficient feasibility and simple preparation method

Active Publication Date: 2012-10-24
泰州市康特生物工程有限公司
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the curative effect of corticosteroids is remarkable, it has several side effects at the same time

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 Preparation and Application of Compound Dexamethasone Injection

[0020] ⑴ Take 6g of dexamethasone and dissolve it into 100ml of medical pure water or acidic aqueous solution to obtain 100ml of solution ①;

[0021] (2) Take 8 mg of tetrodotoxin (purity ≥ 99%), and 100 mg of sodium citrate, and dissolve them into the solution ①;

[0022] (3) Take 1800ml of medical pure water, dissolve all of the solution ①, add 100 grams of polyvinylpyrrolidone (PVP), fully mix, and filter with micromembrane to obtain 1900ml of solution ② for later use;

[0023] (4) Add 0.05% ascorbic acid, 1% benzyl alcohol, and 1% sodium chloride to the solution ②, add medical water to adjust the total amount of the solution ③ to 2000ml, and vacuum filter the micromembrane to remove impurities and bacteria;

[0024] ⑸ Divide 2000ml of the solution ③ into 2000 ampoules on average, the volume of each bottle is 1ml,

[0025] ⑹ Sterilize and seal the above-mentioned ampoules containing the ...

Embodiment 2

[0027] The preparation and application of embodiment 2 compound prednisone oral tablet

[0028] (1) Accurately weigh 8 mg of pure tetrodotoxin, 7.56 mg of citric acid, 12.44 mg of sodium citrate, and 20 g of prednisone raw material, and dissolve them in medical pure water together to obtain 100 ml of drug solution;

[0029] (2) Slowly spray 100ml of the drug solution into 1800g of starch, sieve repeatedly, add 400g of dextrin and 800g of powdered sugar, use 8% starch slurry as a binder to make a soft material, pass through a 16-mesh nylon sieve to granulate, Dry at a temperature of 60°C, pass through a 18-mesh sieve for refinement, add an appropriate amount of magnesium stearate, mix in a blender, and set aside;

[0030] (3) The above-mentioned medicinal powder was made into 4000 tablets with a tablet machine, and in each tablet: the content of prednisone was 5 mg, and the content of tetrodotoxin was 2 micrograms.

[0031] Indications: Mainly used for various acute severe bac...

Embodiment 3

[0032] Embodiment 3 Preparation and Application of Compound Hydrocortisone Injection

[0033] ⑴ Take 20g of hydrocortisone and dissolve it into 100ml of medical pure water or acidic aqueous solution to obtain 100ml of solution ①;

[0034] (2) Take 10 mg of tetrodotoxin, 18.9 mg of citric acid, and 31.1 mg of sodium citrate, and dissolve them into the solution ① together;

[0035] (3) Take 500ml of medical pure water and dissolve it with solution ①, add 50 grams of polyvinylpyrrolidone (PVP), fully mix until transparent, and obtain solution ② 600ml for later use;

[0036] ⑷ Add 0.05% ascorbic acid, 1% benzyl alcohol, and 1% sodium chloride to the solution ②, add medical water to adjust the total amount of the solution to 1000ml (solution ③), and vacuum filter the micromembrane to remove impurities and bacteria. ;

[0037] ⑸ Divide the solution ③ into 2000 ampoules on average, 0.5ml per bottle, sterilize and set aside;

[0038] (5) Put the above-mentioned ampoules in a freeze...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an adrenal cortical hormone compound preparation. An active pharmaceutical ingredient in the preparation comprises the following components: adrenal cortical hormone and tetraodotoxin. The purpose of the preparation is identical with that of a hormone drug in the preparation; and the tetraodotoxin can play a sensitizing role in the preparation so as to improve the hormone use effect, reduce the hormone use dose, reduce or eliminate the hormone tolerability, the hormone dependence and the side effect.

Description

technical field [0001] The invention relates to a compound preparation of adrenocortical hormone, which belongs to the technical field of medicine preparation. Background technique [0002] Hormones are substances secreted by the human body to regulate the normal activities of the body. It can regulate the metabolism of protein, sugar, fat, water, salt and other substances in the human body, maintain the balance of metabolism, and supply energy for life; it can promote the proliferation and differentiation of cells, ensure the normal development of tissues and organs and the renewal of cells It can promote the secretion and regulation of sex hormones, and participate in the whole process of reproduction; it can regulate the central nervous system and autonomic nerves, ensure people's normal thinking and behavior, and regulate the body's adaptation to the environment. If the secretion of hormones is out of balance, it will bring about various diseases. [0003] The most wid...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/573A61P29/00A61K31/529
Inventor 赵继红汤波澜
Owner 泰州市康特生物工程有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com