Biological composite patch for female pelvic floor and manufacturing method thereof

Abstract

The invention relates to a biological composite patch for female pelvic floor and a manufacturing method thereof, and according to the patch, a surface of a polypropylene mesh is coated with a bladder acellular matrix of an animal donor. A bladder obtained from an animal donor needs to be treated by decellularization and freeze-drying; after disinfection, the treated bladder is preserved by plastic packaging at a low temperature; then the obtained bladder acellular matrix is coated onto a surface of a polypropylene mesh. The invention effectively combines biomaterials with inorganic materials, and with the integration of the advantages of both materials, obviously excellent using effect is obtained. Thereinto, the external bladder matrix has the effect of insulating the polypropylene mesh from host tissue, and can significantly improve the biocompatibility. After the patch is implanted, fibrous tissue of a patient is induced to grow into the patch, and finally the restoration of the fibrous tissue of the patient itself is realized.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a patch for repairing female pelvic cavity tissue defects. Background technique [0002] Female pelvic floor dysfunction is a common disease and frequently-occurring disease in middle-aged and elderly women over 50 years old, which seriously affects the life and health of middle-aged and elderly women. The current treatment method is to use some mesh belts or sheets of medical polypropylene synthetic materials to reconstruct the pelvic floor function through surgery. Compared with biological materials, inorganic materials are prone to cause severe inflammatory reactions. Clinical results show that polypropylene mesh has the disadvantages of tissue erosion, poor biocompatibility, and is prone to discomfort caused by foreign body stimulation, tissue erosion, and dyspareunia. Fusion, coupled with aging and hardening and brittleness in the body, friction, displacement, erosion a...

AI Technical Summary

Problems solved by technology

However, these materials have their own unique defects that are difficult to overcome, and they are all in the experimental stage.

Among the alternative materials, the heterogeneous acellular matrix material has the most ideal characteristics. It has a wide range of sources, good strength, and contains bioactive factors. It has excellent tissue compatibility and is an ideal repair material for the pelvic floor in the future. Its long-term curative effect is unstable, and under the current technical conditions, it is still unable to replace the position of polypropylene materials

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