Composite film for treating oral ulcer and preparation method thereof

Abstract

The invention relates to a compound membrane for treating canker sore and a preparation method of the compound membrane, and belongs to the technical field of medicaments for treating oral diseases. The technical scheme comprises the following steps of: dissolving chitosan in a glacial acetic acid aqueous solution with a concentration of 1 percent (v / v, volume ratio) to prepare a chitosan solution with the ratio of the chitosan to solution of 4-8 percent (mg / ml); dripping quercitin into absolute ethanol to be stirred; adding the chitosan solution after the quercitin is dissolved to ensure theratio of the quercitin to solution is 1-5 percent (mg / ml), and sufficiently stirring to prepare a composite membrane solution; preparing a membrane by the composite membrane solution on a glass sheetby using a casting method, naturally cooling at room temperature, and taking the membrane to obtain the quercitin chitosan membrane. The invention has the advantages of scientific formula, simple preparation process, convenience for application, remarkable effect, and no need of special instrument or equipment, can be popularized and applied, accords with the modern Chinese medicament requirementof 'three-effect, three-smallness and three-convenience', and reflects the path of 'innovation, succession and modernization'.

Description

technical field [0001] The invention relates to a composite film for treating oral ulcers and a preparation method thereof, belonging to the technical field of drugs for treating oral diseases. Background technique [0002] Oral ulcer (oral ulcer) is a common disease in oral mucosal diseases, with a high incidence and recurrence rate. The prevalence rate of the general population can reach about 25%, ranking first in oral mucosal diseases. There are obvious individual differences in the results of the combined effects of factors. Psychosocial factors, infection factors, nutritional factors, fluctuations in hormone levels, immune abnormalities, genetic factors, decreased superoxide dismutase activity, microcirculation disturbance and many other factors can lead to the occurrence of the disease, and the specific etiology is still unknown. The main manifestations of oral ulcers are localized hyperemia, edema and ulcer formation on the oral mucosa. Clinically, patients mainly s...

AI Technical Summary

Problems solved by technology

As far as the treatment effect is concerned, the results are unsatisfactory

The main reason is that topical administration of oral ulcers is only carried out within a limited period of time and cannot last for a long time

Oral ulcers are local chronic inflammation, and the oral environment is complicated. Drugs are often diluted by saliva, food, etc. on the surface of oral ulcers, which limits the efficacy of drugs, and the therapeutic effect of systemic medication is not ideal.

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