Salidroside sustained-release tablet and preparation method thereof
A technology for salidroside sustained-release tablets and salidroside sustained-release tablets, which are applied in the field of salidroside sustained-release tablets and their preparation, can solve the problems of inconvenient clinical medication and short half-life of patients, and reduce the occurrence of adverse reactions. efficiency, convenient operation, and the effect of reducing the number of times of use
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Embodiment 1
[0040] Preparation of Salidroside Sustained Release Tablet 1
[0041] 1000 pieces
[0042] Salidroside 12g
[0043] Hypromellose (viscosity: 4000 centipoise) 15g
[0044] Hypromellose (viscosity: 100 centipoise) 30g
[0045] Lactose 150g
[0047] Total weight 208g
[0048] Preparation:
[0049] Grind salidroside, hydroxypropylmethylcellulose (viscosity: 4000 centipoise), hydroxypropylmethylcellulose (viscosity: 100 centipoise) and lactose, pass through a 100-mesh sieve, and mix mechanically. Add 5% povidone aqueous solution (g / 100 ml, model: K30) to granulate during stirring, dry, and granulate. Then the dry granules after granulation are added with magnesium stearate dry powder, placed in a granulator, and mixed evenly. Punch the tablet with 8mm to get 1000 salidroside sustained-release tablets 1.
Embodiment 2
[0051] Preparation of Salidroside Sustained Release Tablet 2
[0052] 1000 pieces
[0053] Salidroside 8g
[0054] Hypromellose (viscosity: 4000 centipoise) 15g
[0055] Hypromellose (viscosity: 50 centipoise) 15g
[0056] Ethyl cellulose (viscosity: 20 centipoise) 15g
[0057] Lactose 150g
[0059]
[0060] Total weight 204g
[0061] Preparation:
[0062] Grinding salidroside, hydroxypropyl methylcellulose (viscosity: 4000 centipoise), hydroxypropyl methylcellulose (viscosity: 50 centipoise), ethyl cellulose (viscosity: 20 centipoise), lactose, and passing 100 mesh sieve, mechanically mixed. During stirring, add 5% povidone (type: K30) aqueous solution to granulate, dry, and granulate. Then the dry granules after granulation are added with magnesium stearate dry powder, placed in a granulator, and mixed evenly. Punch the tablet with 8mm to get 1000 salidroside sustained-release tablets 2.
Embodiment 3
[0064] Preparation of Salidroside Sustained Release Tablet 3
[0065] 1000 pieces
[0066] Salidroside 24g
[0067] Hypromellose (viscosity: 4000 centipoise) 15g
[0068] Hypromellose (viscosity: 100 centipoise) 15g
[0069] Hypromellose (viscosity: 50 centipoise) 15g
[0070] 30g pregelatinized starch
[0071] Lactose 20g
[0073]
[0074] Total weight 120g
[0075] Preparation:
[0076] Salidroside, hypromellose (viscosity: 4000 centipoise), hypromellose (viscosity: 100 centipoise), hypromellose (viscosity: 50 centipoise), pregelatin Grind starch and lactose, pass through a 100-mesh sieve, and mechanically mix. Add 5% povidone (type: K30) during stirring to granulate, dry, and granulate. Then the dry granules after granulation are added with magnesium stearate dry powder, placed in a granulator, and mixed evenly. 8mm punched tablet, get 1000 salidroside sustained-release tablets 3.
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