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Hydrophobic coating for controlling drug release and preparation method thereof

A hydrophobic coating and drug layer technology, applied in the fields of chemical materials and biomedicine, can solve problems such as regulation and inability to achieve hydrophobicity

Inactive Publication Date: 2011-11-23
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, so far, the hydrophobic surfaces reported in the existing literature are all fixed hydrophobicity, regardless of the method of surface composition adjustment or surface microstructure adjustment, and the regulation of hydrophobicity over time cannot be achieved.

Method used

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  • Hydrophobic coating for controlling drug release and preparation method thereof
  • Hydrophobic coating for controlling drug release and preparation method thereof
  • Hydrophobic coating for controlling drug release and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Dissolve 0.15g of polysulfone (PS, Mw=100KDa) in a mixed solvent of 15g of dichloromethane and 4g of ethanol, and stir magnetically to obtain a fully dissolved PS electrostatic spray solution.

[0068] Set the voltage of the electrospinning technical parameters to 10KV, the flow rate to 0.06ml / min, the distance from the needle to the collecting plate to 15cm, the temperature to 25°C, and the relative humidity to 50%. Use a flat plate to collect micro-nano particles, the scanning electron microscope photos and contact angles Such as figure 1 shown. The solution at the electrospray nozzle is affected by the high-voltage electric field to form a liquid jet, and then atomized into liquid particles. In the process of continuous atomization and splitting of the liquid particles, the solvent in the liquid particles evaporates rapidly, and finally, on the receiving plate Polymer micro-nano particles are obtained, the particle size of the polymer micro-nano particles ranges fro...

Embodiment 2

[0070] Dissolve 0.15g of polysulfone (PS, Mw=100KDa) and 0.0015g of polyvinylpyrrolidone (PVP, Mw=130KDa) in a mixed solvent of 15g of dichloromethane and 4g of ethanol, and stir magnetically to obtain fully dissolved PS and PVP Polymer mixed electrostatic spray solution. By adjusting the technical parameters of electrostatic spraying and using a flat plate as a collector, the PS / PVP composite micro-nano particle coating is collected. The initial contact angle of the coating surface is 158.3°, and the average particle size of the obtained PS / PVP particles is 856nm. Collect the electrostatic spray particle coating with a thickness of more than 10 μm, and its scanning electron microscope photos and contact angles are as follows: figure 2 shown.

Embodiment 3

[0072] Dissolve 0.15g of polysulfone (PS, Mw=100KDa) in a mixed solvent of 10g of dichloromethane and 3g of N,N-dimethylformamide, and stir magnetically to obtain a fully dissolved PS electrostatic spray solution.

[0073] Set the voltage in the electrospinning technical parameters to 15KV, the flow rate to 0.5ml / min, the distance from the needle to the collecting plate to 10cm, the temperature to 15°C, and the relative humidity to 35%, using a flat plate to collect micro-nano particles. The solution at the electrospray nozzle is affected by the high-voltage electric field to form a liquid jet, and then atomized into liquid particles. In the process of continuous atomization and splitting of the liquid particles, the solvent in the liquid particles evaporates rapidly, and finally, on the receiving plate The polymer micro-nanoparticles are obtained, the particle size of the polymer micro-nanoparticles ranges from nanometers to micrometers, the average particle diameter of the ob...

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Abstract

The invention relates to a hydrophobic coating for controlling drug release and a preparation method thereof, belonging to the field of chemical materials and biological medicine. The hydrophobic coating comprises a drug layer and a combined layer which is formed by hydrophobic coatings variable with time, wherein the hydrophobic coatings variable with time are covered over the drug layer and have a structure of particles, beads or fibers, the size of particles in the particle structure is 50 nm to 5 mu m, the diameter of a single bead and fiber in the bead structure are 100 nm to 5 mu m and 50 nm to 2 mu m respectively, and the diameter of fiber in the fiber structure is 100 nm to 5 mu m. The preparation method is to fix a substrate with the drug layer, to control the concentration of each high molecular solution and to obtain the hydrophobic coating through the method of electrostatic spraying. When the hydrophobic coating variable with time provided in the invention is immersed in an aqueous solution, surface hydrophobicity of the coating changes with the increases of time, and therefore the rate that water molecules enter into and go out of the coating is regulated, thereby realizing further regulation of the drug release rate of a sustained release agent as a whole and satisfying clinical treatment requirements for surface dosing with medical instruments.

Description

technical field [0001] The invention belongs to the fields of chemical materials and biomedicine, and in particular relates to a hydrophobic coating for controlling drug release, a preparation method and application thereof. Background technique [0002] In the current field of drug release, the drug release in the carrier is mainly regulated by the physical and chemical properties of the carrier material and the carrier dosage form, for example, through temperature-sensitive polymers, acidity-sensitive polymers, surface erosion degradation polymers, ion-sensitive polymers, etc. Special physical and chemical properties regulate the specific release of drugs, and the specific release of drugs is regulated by carrier dosage forms such as microspheres, liposomes, micelles, coatings, and fibers. However, for a specific pharmaceutical preparation, the corresponding release rate is usually obtained by changing the carrier material [Chem.Rev.2005, 105, 4205-4232.]. [0003] For ex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/16A61K47/32A61K47/34A61K47/42
Inventor 常江崔文国
Owner SHANGHAI JIAO TONG UNIV
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