Polylactic acid-glycolic acid copolymer particle bracket for injection and manufacturing method thereof

Abstract

The invention discloses a polylactic acid-glycolic acid copolymer particle bracket for injection and a manufacturing method thereof. The polylactic acid-glycolic acid copolymer particle bracket for injection comprises the following components in parts by weight: 0.8-1 part of biodegradable polymer composed of polylactic acid and glycolic acid and 3 parts of temperature-sensitive adjuvant. After the copolymer particle bracket disclosed by the invention is injected into a human body, a microenvironment bracket beneficial to the growth of tissue cells is formed in the body, thereby being very favorable for cells to exchange oxygen, provide nutrient substances and discharge wastes; and in a shorter time, the particle bracket can be completely degraded biologically to finally become carbon dioxide and water to be naturally discharged out of the body. In the invention, the used raw materials and metabolic products are harmless and nontoxic to the human body; the particle bracket is in a liquid state before injection and becomes a jelly state due to the temperature change after being injected into the human body, thereby being very convenient for a plastic part needing a fixed shape; andthe bracket disclosed by the invention has the action of carrying antibiotics and does not need additional administration of antibiotics in the treatment process.

Description

technical field [0001] The invention relates to a polylactic acid-glycolic acid copolymer granular support for injection and a manufacturing method thereof. Background technique [0002] The number of tissue and organ defects caused by trauma, congenital diseases, cancer, infection, inflammation, etc. is increasing day by day. At present, autologous, allogeneic or xenogeneic tissues and organs are often used for clinical transplantation and repair, but it is still difficult to meet clinical needs due to insufficient supply sources, damage to donors, and immune rejection. The traditional repair method is autologous tissue transplantation. Although satisfactory curative effect can be obtained, it is at the expense of autologous healthy tissue, which will cause many complications and additional damage; human organ failure, drug treatment, temporary replacement The therapy can save the lives of some patients, but the sources of donor organs are extremely limited, and immunosupp...

AI Technical Summary

Problems solved by technology

[0008] Currently commonly used materials are likely to induce thromboembolic diseases in the human body due to their own characteristics, and because they are not biodegradable, they have accumulation problems in the body

When the current synthetic polymers and tissue regeneration substances composed of other polymers are injected into the skin, the space for cells and tissues in the human body to attach and grow is limited. Although it provides cells with a certain growth space, it is not convenient for cell replacement. Oxygen, provide nutrients and discharge waste. At the same time, the applicability of the material after injection into the human body is poor, and it is no longer suitable for plastic parts that require a fixed shape. There is a phenomenon of flow at the injection site, which is also a problem that must be solved.

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