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Phloretin pellet and preparation method thereof

A phloretin and pellet technology, applied in the field of medicine and food, can solve the problems of low bioavailability, long disintegration time, unstable release, etc., and achieve the effects of high bioavailability, good effectiveness and controlled release amount

Inactive Publication Date: 2011-08-31
天津市尖峰天然产物研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, phloretin products are well received by consumers, but due to the poor water solubility of phloretin, the bioavailability is low; while phloretin is commonly used in ordinary tablets and capsules, but the above dosage forms disintegrate Disadvantages such as long time and unstable release

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take the following ingredients for use: 15 grams (15%) of phloretin, 84 grams (84%) of sucrose, dextrin, starch, crystalline cellulose, lactose and methylcellulose, 1 gram of polyvinylpyrrolidone (1 %);

[0024] Preparation:

[0025] (1) Take the phloretin of the above formula and add the excipients, pulverize it to the micronization level with a ball mill, and mix;

[0026] (2) Dissolve the adhesive in 75% ethanol solution;

[0027] (3) Pellets are made by extrusion-spheronization method.

Embodiment 2

[0029] Take the following ingredients: 20 grams (20%) of phloretin, 79 grams (79%) of microcrystalline cellulose, 1 gram (1%) of hydroxypropyl methylcellulose;

[0030] Preparation:

[0031] (1) Take the phloretin of the above formula and add the excipients, pulverize it to the micronization level with a ball mill, and mix;

[0032] (2) Dissolve the adhesive in water;

[0033] (3) Pellets are made by the pan-pill method.

Embodiment 3

[0035] Take the following ingredients for use: 15 grams (15%) of phloretin, 84 grams (84%) of sucrose, dextrin, starch, crystalline cellulose, lactose and methylcellulose, 1 gram of polyvinylpyrrolidone (1 %);

[0036] Preparation:

[0037] (1) Take the phloretin of the above formula and add the excipients, pulverize it to the micronization level with a ball mill, and mix;

[0038] (2) Dissolve the adhesive in absolute ethanol;

[0039] (3) Using centrifugal-fluidized pelletizing method to make pellets.

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PUM

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Abstract

The invention relates to a preparation method of a phloretin pellet, which is simple, convenient and easy to operate. The preparation method overcomes the shortcomings in the prior art, and phloretin is prepared into a pellet type product with controllable release in the body and high bioavailability, so as to better meet the demands of general consumers. In the preparation method, the phloretin is ground into fine powder by adopting micronization technology, and the average particle size of the fine powder is generally less than 15 um and mainly distributed in the range of 5-20 um. By adopting the preparation method, the absorption rate of effective ingredients is increased, and the bioavailability is improved; and by adopting water-soluble adhesive and excipient, the solubility of the phloretin in the body is greatly enhanced, and as the solubility of the micron-sized effective ingredients in the gastrointestinal tract is significantly increased, the bioavailability of the micron-sized effective ingredients is increased, and the onset time of the micron-sized effective ingredients is shortened.

Description

Technical field [0001] The invention relates to the technical field of medicine and food, in particular to a phloretin pellet and a preparation method thereof. Background technique [0002] Phloretin is a natural active substance found in apples, pears and other fruits and a variety of vegetable juices. It is named only because of the relatively concentrated content in the rhizomes or root barks of these plants. Phloretin can activate cellular protein kinase, which is effective for disordered cell proliferation. It is an anti-mutagenic factor in food and can be used for the treatment of skin cancer and other tumors. It has strong anti-oxidation properties, and its antioxidant concentration against oils Between 10 and 30PPm; external use can prevent carbohydrates from entering epidermal cells, thereby inhibiting excessive secretion of skin glands, treating exuberant acne; inhibiting the activity of melanocytes, and diminishing various skin spots. [0003] At present, phloretin prod...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/12A23L1/29A61P17/00A61P35/00A61P39/06A23L33/00
Inventor 田婷
Owner 天津市尖峰天然产物研究开发有限公司
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