Kit for detecting alcoholic liver disease susceptibility

Abstract

The invention discloses a kit for detecting alcoholic liver disease susceptibility. The kit detects three genes closely related with an alcoholic liver disease, namely an ADH2 gene of alcohol dehydrogenase, an ALDH2 gene of acetaldehyde dehydrogenase and a CYP2E1 gene of cytochrome P4502E1. The simultaneously detected SNP sites comprise an rs1229984 site of the ADH2 gene, an rs671 site of the ALDH2 and an rs2031920 site of the CYP2E1. Whether a detected crowd carries ''alcoholic liver disease susceptible genes'' can be clearly judged by using the kit, detecting a group of genes and sites related with the alcoholic liver disease susceptibility, using specific primers and probes and combining mononucleotide extension technology and micro array chip technology, and the alcoholic liver disease susceptible crowd is screened from the crowd, so that poor life habits are changed and the purpose of prevention is achieved.

Description

technical field [0001] The present invention relates to a kit for detecting susceptibility to disease, especially a kit for detecting susceptibility to alcoholic liver disease. Predicting an individual's susceptibility to leukemia. Background technique [0002] Alcoholic liver disease (ALD) is liver damage caused by long-term drinking, which can be manifested in three forms: alcoholic fatty liver, alcoholic hepatitis, and alcoholic cirrhosis. These three forms may exist alone or in admixture. According to statistics, there are about 15 million to 20 million people in the world who are alcoholics, and about 10% to 20% (1.5 million to 4 million) of them have alcoholic liver disease in varying degrees. In my country, with the continuous improvement of people's living standards and economic conditions, the incidence of ALD has also been increasing year by year in recent years. Alcohol has become the second leading cause of liver damage after viruses. [0003] After drinking, ...

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is, by detecting a group of genes and loci related to the susceptibility of alcoholic liver disease, using specific primers and probes, combining single nucleotide extension technology with microarray chip technology, to comprehensively detect and Analyze whether the tested population carries the "alcoholic liver disease susceptibility gene", screen out the susceptible population of alcoholic liver disease from the crowd, change bad living habits, and achieve the purpose of prevention

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