Quality detection method for intestines and stomach easing capsule

A quality inspection method and technology for Changweishu capsules are applied in the field of quality inspection of Changweishu capsules, which can solve the problems of poor specificity of leachate detection and no content detection.

Active Publication Date: 2011-07-27
唐秋海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing Changweishu Capsule drug standard stipulates the thin-layer chromatography identification of woody and spidery incense contained in this prescription. After long-term testing, it has been proved that this detection method is easy to operate, has good reproducibility, and strong specificity, but it only measures the leaching There is no content detection, and the specificity of leachate detection is not good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The medicinal formula of Changweishu Capsules is: Caoguo 300g, Muxiang 300g, Spiderxiang 600g, Purple Burnet 600g, Caoxue 400g, made by the following method: crush Caoguo into coarse powder, extract with steam distillation Volatile oil is collected in another device, and the distilled medicinal liquid is used for later use; spider incense and woody fragrance are crushed into coarse powder, extracted three times with ethanol under reflux, each time for 1 hour, filtered, combined filtrates, recovered ethanol under reduced pressure, and concentrated to a relative density of 1.30~1.35 (70°C) thick ointment for later use; decoct the dregs, purple burnet, and rhizome with water twice, 1.5 hours each time, combine the decoction, filter, add the mother liquor after the above-mentioned Tsaoguo distillation, Concentrate to a thick paste with a relative density of 1.30-1.35 (70°C), add the above thick paste, dry, crush, add starch, mix well, make granules, dry; spray tsaoguo volati...

Embodiment 2

[0029] 2. Content determination

[0030] (1) Chromatographic conditions and system applicability experiment: Octadecylsilane bonded silica gel was used as filler, methanol-water (65:29) solution was used as mobile phase, the detection wavelength was 225nm, and the number of theoretical plates was based on that of woody hydrocarbon. Ester peak calculation is not less than 3000;

[0031] (2) Same as Example 1.

[0032] (3) Preparation of the test solution: Grind the content of the product under the difference in loading amount, mix it evenly, take 0.6g, accurately weigh it, put it in a stoppered Erlenmeyer flask, and accurately add 20% of chloroform ml, plugged, weighed, shake well, leave overnight, ultrasonic treatment (250W, 50Hz) for 20 minutes, take out, let cool, weigh again, make up the lost weight with chloroform, shake well, filter , take 10ml of the continued filtrate, place it in an evaporating dish, evaporate it to dryness, add methanol to dissolve the residue and t...

Embodiment 3

[0035] 2. Content determination

[0036](1) Chromatographic conditions and system suitability experiment: Octadecylsilane bonded silica gel was used as filler, methanol-water (71:35) solution was used as mobile phase, the detection wavelength was 225nm, and the number of theoretical plates was based on the number of woody hydrocarbons. Ester peak calculation is not less than 3000;

[0037] (2) Same as Example 1.

[0038] (3) Preparation of the test solution: Grind the content of the product under the item of difference in loading, mix well, take 0.6g, accurately weigh it, put it in a stoppered Erlenmeyer flask, and accurately add 30ml of chloroform , Sealed, weighed, shake well, leave overnight, ultrasonic treatment (250W, 50Hz) for 40 minutes, take out, let cool, weigh again, make up for lost weight with chloroform, shake well, filter, Take 10ml of the filtrate and place it in an evaporating dish, evaporate it to dryness, add methanol to dissolve the residue and transfer it...

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PUM

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Abstract

The invention discloses a quality detection method for an intestines and stomach easing capsule. In the formula, the intestines and stomach easing capsule consists of 300g of tsaoko amomum fruit, 300g of elecampane, 600g of jatamans valeriana rhizome, 600g of geranium strictipes knuth and 400g of rhizoma polygoni paleacei, and the raw materials are prepared into the capsule. The quality detection method for the intestines and stomach easing capsule comprises the steps of identification and content measuring; the content measuring comprises the following steps: firstly, the experiment of chromatograph condition and system application; secondly, the preparation of reference substance solution; thirdly, the preparation of test substance solution; and fourthly, measuring. In the quality detection method for the intestines and stomach easing capsule, the content detecting item is added, one of the main ingredients, namely costundide, is measured by adopting the high performance liquid chromatography, the method is made after a plurality of tests, and is re-checked by foodstuff and drug control institute in Yunnan province, In the method, the operation is simple and convenient, the specificity is strong and the repeatability is good, so that the quality control and test is safer and more effective.

Description

technical field [0001] The invention relates to the technical field of drug testing, in particular to a quality testing method for Changweishu capsules. Background technique [0002] Changweishu Capsules are made from the prescription: Caoguo 300g, Muxiang 300g, Spiderxiang 600g, Burnet burnet 600g, Dracaena casserole 400g through the following preparation method: crush the grass fruit into coarse powder, extract the volatile oil by steam distillation, and The medicinal liquid after distillation is collected in a vacuum cleaner, and the distilled medicinal liquid is used for later use; spider incense and woody incense are crushed into coarse powder, extracted three times with ethanol under reflux, each time for 1 hour, filtered, combined filtrate, recovered ethanol under reduced pressure, and concentrated to a relative density of 1.30-1.35 (70°C) thick ointment for later use; decoct dregs, purple burnet, and rhizome with water twice, 1.5 hours each time, combine the decoctio...

Claims

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Application Information

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IPC IPC(8): A61K36/9064G01N30/02G01N30/90A61P1/04A61P1/14
Inventor 唐秋海
Owner 唐秋海
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