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Anti-cervical cancer effect of oleanolic acid and pharmaceutical preparation thereof

A kind of pharmaceutical preparation, technology of oleanolic acid, applied in the field of traditional Chinese medicine

Inactive Publication Date: 2011-07-27
林秀坤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Before the present invention, there is no report on using oleanolic acid as a raw material to study pharmaceutical dosage forms and to prevent and treat cervical cancer

Method used

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  • Anti-cervical cancer effect of oleanolic acid and pharmaceutical preparation thereof
  • Anti-cervical cancer effect of oleanolic acid and pharmaceutical preparation thereof
  • Anti-cervical cancer effect of oleanolic acid and pharmaceutical preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 tablet

[0033] Oleanolic acid 1000g, medicinal starch 100g, mix evenly, granulate with appropriate amount of ethanol as a binder, dry, granulate through a granulator, compress into tablets, 0.30g per tablet, orally, 1-2 tablets each time, twice daily.

Embodiment 2

[0034] The preparation of embodiment 2 capsules

[0035] Oleanolic acid 1000g, medicinal starch 100g, mix evenly, use appropriate amount of ethanol as a binder to granulate, dry, pass through a 120 mesh sieve for granulation, pack 0# capsules, 0.300g per capsule, take 1-2 capsules each time , twice a day.

Embodiment 3

[0036] The preparation of embodiment 3 dropping pills

[0037] polyethylene glycol 4000 400g, melted on a water bath, added 250g of oleanolic acid raw material, stirred evenly, poured into the insulation tube, adjusted the constant temperature device, so that the liquid medicine was dripped into the cooled liquid paraffin at 80-90°C (temperature ± 4°C ), after dripping, pour the pills into the filter paper to absorb the paraffin oil, then add a small amount of talcum powder, mix well, and get 10,000 oleanolic acid dripping pills. Take orally, four capsules at a time, three times a day, after meals.

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Abstract

The invention discloses a new medical application of oleanolic acid in cervical cancer resistance, and also discloses clinically acceptable pharmaceutical preparations such as tables, capsules, pills, injections and the like which are prepared by using oleanolic acid as a pharmaceutical raw material. The oleanolic acid pharmaceutical preparation of the present invention comprises 1%-99% of oleanolic acids and 99%-1% medicinal excipients (including other compatible drugs). The oleanolic acid and the pharmaceutical preparations thereof provided by the invention have an excellent anti-cervical cancer effect which is represented by significant inhibitory activity against in vitro human cervical cancer cells and significant tumor inhibitory activity against a transplanted tumor in nude mice of the cancer cell. In addition, the active components of the pharmaceutical preparation are traditional Chinese medicine extracts, so the preparation has the advantage of less toxic and side effect than chemotherapeutic drugs.

Description

technical field [0001] The invention relates to the application of oleanolic acid (Oleanolic acid) in anti-cervical cancer and its pharmaceutical preparation, belonging to the field of traditional Chinese medicine. Background technique [0002] Oleanolic acid (Oleanolic acid) is a pentacyclic triterpenoid that exists in various plants in the form of free bodies and glycosides. The main sources of extraction are the leaves of Oleanaceae Oleanaceae, Ligustrum privet; the whole plant of Gentianaceae, Swertia chinensis; the leaves and roots of Umbelliferae celery; the leaves and roots of Araliaceae Aralia Root bark and stem bark; Cucurbitaceae large-seeded snow gall, cute snow gall, root tuber of Chinese snow gall. [0003] The reported medicinal effects of oleanolic acid mainly include protecting the liver and reducing enzymes, promoting liver cell regeneration, anti-inflammation, strengthening the heart, and diuresis. It also has the effects of lowering blood sugar, blood fat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P35/00
Inventor 林秀坤廖德忠刘海洲
Owner 林秀坤
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