Medicament for treating cerebral blood-vessel dilate and preparation method thereof
A cerebrovascular and vinpocetine technology, applied in the field of pharmaceutical preparations, can solve problems such as poor water solubility, affecting drug absorption and bioavailability
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[0085] Embodiment 1 (by 1000 bottles)
[0086] Take the raw and auxiliary materials by the following parts by weight:
[0087] 10 parts by weight of vinpocetine, 1 part by weight of vitamin C, 2 parts by weight of sodium metabisulfite, 200 parts by weight of mannitol, 100 parts by weight of sorbitol, and 4 parts by weight of tartaric acid.
[0088] Above-mentioned dosage form preparation method of the present invention is as follows:
[0089] 1. Take freshly prepared water for injection, boil it, wait until the temperature drops to 40°C, and set aside.
[0090] 2. Measure 1600ml of the above-mentioned water for injection, add vitamin C, stir to dissolve, slowly add vinpocetine, after dissolving, add sodium metabisulfite, sorbitol, mannitol, and tartaric acid to dissolve.
[0091] 3. Stir well, measure the pH value, adjust the pH value to 3.5 (3.0-4.0) with tartaric acid, add 0.03% (g / ml) needles, stir well with activated carbon, stir and absorb for 20 minutes, decarbonize an...
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