Compound preparation for promoting neuromuscular regeneration and preparation method thereof

Abstract

The invention belongs to the field of traditional Chinese medicaments and relates to a compound preparation for promoting neuromuscular regeneration and a preparation method thereof. The compound preparation is prepared from raw material medicaments, such as codonopsis pilosula, astragalus, root of red-rooted salvia and the like, and medicinally acceptable auxiliary materials or auxiliary ingredients according to a specific weight ratio by a water extraction method. The result of a pharmacological test shows that the compound preparation can increase GAP-43 expression in early damaged nerve, can be competitively combined to a G protein reaction site, can promote quick growth of axon and can contribute to reconstruction of synapse. The result of an animal test shows that the compound preparation promotes metabolism of an organism, increases blood supply of a damaged part, eliminates degenerated myelin sheath, promotes fission and proliferation of Schwann cells and has obvious effect of accelerating regeneration of peripheral nerves after the peripheral nerves are damaged. The compound preparation can be further prepared into a medicament clinically used for promoting neuromuscular regeneration so as to bring benefit to more patients suffered from nerve injury.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a compound preparation of traditional Chinese medicines, in particular to a compound preparation containing Codonopsis pilosula and other traditional Chinese medicines for promoting neuromuscular regeneration and a preparation method thereof. Background technique [0002] Trauma is one of the three major causes of death since the 20th century. In developed countries, trauma is also the first cause of death and disability among young and middle-aged adults, which brings extreme pain to patients and huge economic losses to society. With the development of modern medicine, especially the development of microsurgery after the 1960s, the survival rate after trauma has been greatly improved, and many patients have seen hope. However, among the rescued patients, there are still many injured. Can not return to the original job, because the recovery of neuromuscular function aft...

AI Technical Summary

Problems solved by technology

As early as the 1950s, foreign scholars discovered Nerve Growth Factor (NGF), and successive studies reported that NGF family (NGF, BDNF, NT-3, NT-4, NT-5, etc.) and non-NGF family (CNTF , IGF, GDNF, SDNF, etc.) a variety of different sources of neurotrophic factors, and a series of results have been achieved in experimental research, but whether it can promote nerve regeneration in clinical practice is still controversial, and so far No breakthrough clinical progress yet