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Condom with localized active agent

A technology of condoms and active ingredients, applied in male contraceptives, drug delivery, pharmaceutical formulations, etc., can solve the problem of not providing localized delivery of active ingredients

Inactive Publication Date: 2011-06-01
ANSELL HEALTHCARE PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these uses of waxes do not provide localized delivery of active ingredients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1A

[0034] Melt the modified natural wax and the polyethylene glycol polymer wax with appropriate molecular weight and melting point to make the wax several degrees above the melting point (~1-10°C), and add 100 mg of nonoxynol-9 liquid Among them to form a mixture. Drop the mixture beads onto the inner surface of the end of the condom and allow it to reach room temperature and solidify the wax beads. Then, wrap the condom. The amount of nonoxynol-9 can be as high as 15-20% of the weight of the wax. The use of higher concentrations of nonoxynol-9 may result in segregation of nonoxynol-9 in the wax beads, which may lead to possible skin irritation or even local weakening of the condom. 0.5 grams of wax beads may contain 75 mg of nonoxynol-9.

Embodiment 1B

[0036] Melt the raw material of the mixture of polyethylene glycol wax PEG-6 and PEG-32 sold by Clariant under the product name Lanogen 1500, so that the wax is several degrees above the melting point (~1-10°C). Phenol-9 is added to form a homogeneous wax mixture that does not separate. Drop the mixture beads onto the inner surface of the end of the condom and allow it to reach room temperature and solidify the wax beads.

Embodiment 2

[0038] Melt the modified natural wax and polyethylene glycol polymer wax with appropriate molecular weight and melting point to make the wax several degrees above the melting point (~1-10°C), and add 100 mg of nitroglycerin liquid to it to form a mixture . Drop the mixture beads onto the inner surface of the end of the condom and allow it to reach room temperature and solidify the wax beads. Then wrap the condom.

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PUM

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Abstract

Provided are condoms and methods of making and using the same, the condoms having an elastomeric layer and a low melt wax bead which comprises an active ingredient mixed therein, wherein the bead is affixed on the interior surface of the elastomeric layer in the tip of the condom. Active ingredients can include spermicides such as nonoxynol-9 and vasodilators such as niacin, sildenafil citrate, and nitroglycerin and male desensitizing agents such as benzocaine. The bead can comprise a natural wax in combination with polyethylene glycol or it can be a polyethylene glycol-based wax. The exterior surface of the elastomeric layer is substantially free of the active ingredient.

Description

Technical field [0001] Embodiments of the invention relate to condoms with active ingredients positioned at the closed end of the condom. In particular, a condom with one or more active ingredients is provided, the active ingredients are dissolved or mixed as fine water-soluble powder in low melting wax beads. For example, ingredients include liquid nonoxynol-9 and other spermicides, as well as niacin, nitroglycerin and sildenafil citrate and other vasodilators. Background of the invention [0002] Condoms and other contraceptives and protective devices provide a physical barrier against the transmission of body fluids or other fluids. Chemical barriers can also be used alone or in combination with condoms to prevent such transmission. In some cases, if the physical barrier is broken, the chemical barrier can be used as a supplementary form of protection. U.S. Patent No. 5,284,158 (Mallette) provides a sensitive condom in which a spermicide is placed in the latex cap of the co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F6/04
CPCA61K9/0034A61F6/04
Inventor 蔡明心原翠诗大卫·M·卢卡斯伯顿·万卢耶恩迈克尔·S·责德里斯
Owner ANSELL HEALTHCARE PRODS
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