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Nitrogen and sulfur heterocyclic compound, preparation method and application thereof

A technology of cyclic compounds and nitrogen-sulfur heterocycles, which is applied in the field of marine natural product chemistry, can solve the problems of reported and unseen chemical structures of nitrogen-sulfur heterocyclic rings, and achieve the effects of simple preparation methods, low cost, and low pollution

Inactive Publication Date: 2011-05-18
广西海洋研究所有限责任公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Most of these studies focus on active polysaccharides, polypeptides, etc., and so far there has been no report on the chemical structure of the nitrogen-sulfur heterocycles contained in them.

Method used

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  • Nitrogen and sulfur heterocyclic compound, preparation method and application thereof
  • Nitrogen and sulfur heterocyclic compound, preparation method and application thereof
  • Nitrogen and sulfur heterocyclic compound, preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] The preparation method of nitrogen sulfur heterocyclic compound:

[0024] Wash and remove 15kg of cockles to obtain 5kg of meat, homogenate the meat, add 5 times the volume of 85% ethanol to soak for 3 times, soak for 7 days each time, and use ultrasonication once every 3 days, each time with a 40KHz ultrasonic instrument 2-4 hours. Combine three ethanol extracts, reclaim ethanol under reduced pressure to obtain a fluid extract with a density of 0.5 g / ml, dissolve the fluid extract in 3 times the amount of water, and extract with an equal volume of ethyl acetate and n-butanol 1: 1 mixed solvent for 3 Once, an equal volume of acetone was added to the extracted aqueous layer, and left to stand at room temperature for 6 hours to obtain crude crystals. Add 15ml of methanol, water and other solvents to the crude crystals for recrystallization, obtain crystals after standing at room temperature for 24 hours, filter and dry at room temperature for 1 hour to obtain 2.3 grams o...

Embodiment 2

[0026] The preparation method of nitrogen sulfur heterocyclic compound:

[0027] Wash and remove 15 kg of cockles to obtain 5 kg of meat, homogenate the meat, add 5 times the volume of 95% ethanol to soak for 10 hours, carry out reflux extraction at 50 ° C for 3 hours, and recover ethanol to obtain a density of 1 g / ml of liquid extract, dissolve the liquid extract in 5 times the amount of water, extract 5 times with an equal volume of ethyl acetate and n-butanol 1:1 mixed solvent, add an equal volume of acetone to the extracted water layer, and let it stand at 4°C. Crude crystals were obtained after standing for 6 hours. Add 9 ml of mixed solvents such as water and methanol to the crude crystals for recrystallization, and obtain crystals after standing at room temperature for 6 hours, filter the crystals and dry at room temperature for 5 hours to obtain 2.3 grams of pure nitrogen-sulfur heterocycle compounds of the present invention. The operation must not exceed 50°C, and t...

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Abstract

The invention relates to a nitrogen and sulfur heterocyclic compound, a preparation method and application thereof. Search shows that hairy clams contain a lot of active substances, such as anticancer peptides and polysaccharides, but no related technology discloses heterocyclic compounds in the hairy clams. In the invention, a nitrogen and sulfur heterocyclic compound, 1,5,9,13-tetrathia-2,6,10,14-tetraazacyclohexahecane, is extracted and separated from the hairy clams and has the molecular formula of C8H20N4S4. Experiment results show that the nitrogen and sulfur compound extracted and separated from the hairy clams has antibacterial effect, which indicates that the nitrogen and sulfur compound provided by the invention can be used as an antibacterial agent.

Description

technical field [0001] The present invention relates to a nitrogen-sulfur heterocyclic compound, specifically a nitrogen-sulfur heterocyclic compound extracted, isolated and purified from sea shell clams, belonging to the field of marine natural product chemistry, and the present invention also relates to the nitrogen-sulfur heterocyclic compound The preparation method and use of it. Background technique [0002] Hair clam (Scapharca subcrenata), also known as "hair clam and hemp clam", is a mollusc shellfish belonging to the family Scapharca subcrenata, which is distributed in the coastal areas of China, Korea and Japan, especially in the Bohai Sea and the East China Sea. Clams have high nutritional and medicinal value. They have the effects of resolving phlegm, softening firmness, dispelling blood stasis, and eliminating stagnation. They can treat diseases such as phlegm accumulation, stomach pain, noise, acid regurgitation, scarring, scrofula, and dental malnutrition. It ...

Claims

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Application Information

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IPC IPC(8): C07D285/00A61K31/395A61P31/04
Inventor 徐艳罗晓东王志成童万平赖陈民乐王良昭
Owner 广西海洋研究所有限责任公司
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