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Method for preparing anticoagulant polysulfones material by fourier reaction grafting

A technology of Fourier reaction and anticoagulation, which is applied in anticoagulation treatment, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problem of coagulation and thrombus affecting the application and effect of polysulfone devices, etc. problems, achieve good anticoagulant performance, improve blood compatibility, and reduce platelet adhesion

Inactive Publication Date: 2011-05-04
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] When polysulfone is in contact with blood, because it can activate the body's coagulation system, it is easy to produce coagulation and thrombus, which will affect the application and effect of polysulfone devices.

Method used

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  • Method for preparing anticoagulant polysulfones material by fourier reaction grafting
  • Method for preparing anticoagulant polysulfones material by fourier reaction grafting
  • Method for preparing anticoagulant polysulfones material by fourier reaction grafting

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] (1) Preparation of carboxylated polysulfone surface: Dissolve tin tetrachloride with a molar ratio of 0.05:1 to acrylic acid in a mixed solution of acrylic acid:phosphoric acid (V:V is 3:1), and immerse the polysulfone membrane in 50 mL of the solution Medium, 30°C for 60 minutes, rinse thoroughly with triple distilled water. Energy spectrum analysis shows that the surface of the obtained polysulfone is carboxylated, so the content of oxygen element increases.

[0047] (2) Preparation of aminated polysulfone surface: prepare 90% ethanol aqueous solution, then take 1 part of KH550 and dissolve it in 49 parts of ethanol aqueous solution, immerse the above-mentioned polysulfone membrane in 50 mL of the solution, and after grafting at room temperature for 30 minutes, 90 % ethanol, triple distilled water to fully rinse. Energy spectrum analysis shows that the silicon element in silane appears on the surface of the polysulfone obtained (see Figure 4b ).

[0048] (3) Prepa...

Embodiment 2

[0057] (1) Preparation of carboxylated polysulfone surface: Dissolve tin tetrachloride with a molar ratio of 0.05:1 to acrylic acid in a mixed solution of acrylic acid: phosphoric acid (V: V is 1: 1), and immerse the polysulfone membrane in 50 mL of the solution Medium, 40°C for 30 minutes, rinse thoroughly with triple distilled water. Energy spectrum analysis shows that the surface of the obtained polysulfone is carboxylated, so the content of oxygen element increases.

[0058] (2) Preparation of aminated polysulfone surface: Same as in Example 1. Energy spectrum analysis shows that the silicon element in silane appears on the surface of the obtained polysulfone.

[0059] (3) Preparation of a polysulfone surface on which an anticoagulant is grafted: same as in Example 1. Energy spectrum analysis showed that the kurtosis of silicon element on the surface of polysulfone decreased obviously.

[0060] (4) Evaluation of anticoagulant performance: same as in Example 1.

[0061]...

Embodiment 3

[0063] (1) Preparation of carboxylated polysulfone surface: Same as Example 1. Energy spectrum analysis shows that the surface of the obtained polysulfone is carboxylated, so the content of oxygen element increases.

[0064] (2) Preparation of aminated polysulfone surface: prepare 0.2% KH550 silane solution with 90% ethanol, immerse the polysulfone membrane in 50 mL of the solution, graft overnight at room temperature, and rinse thoroughly with 90% ethanol and triple distilled water. Energy spectrum analysis shows that the silicon element in silane appears on the surface of the obtained polysulfone.

[0065] (3) Preparation of polysulfone material grafted with anticoagulant: same as in Example 1. Energy spectrum analysis showed that the kurtosis of silicon element on the surface of polysulfone decreased obviously.

[0066] (4) Evaluation of anticoagulant performance: same as in Example 1.

[0067] The results of recalcification time test, hemolysis rate test, platelet adhes...

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Abstract

The invention discloses a method for preparing anticoagulant polysulfone material by fourier reaction grafting, which comprises the steps of: introducing carboxyl into the polysulfone surface of through fourier reaction; then grafte polymerizing amino silane onto the carboxyl terminal to turn the polysulfone surface into silane, and finally combining anticoagulant medicament, as a covalent bond, to the amino end through a crosslinking agent so as to realize grafting anticoagulant medicament onto polysulfone surface and to obtain polysulfone material with excellent anticoagulant performance. The method is simple and rapid in process, and high in controllability. The material obtained has excellent anticoagulant performance, and may not disturb coagulation system of a body. The invention can be widely applied to the fields of extracorporeal circulation (e.g. artificial kidney), anticoagulant coating, biosensor, and bimolecular diagnosis and detection.

Description

technical field [0001] The invention relates to a method for preparing anticoagulant polysulfone material by using Fourier reaction grafting. Background technique [0002] When artificial biopolymer materials come into direct contact with blood, they will activate the coagulation system to produce coagulation and thrombus, thus limiting the application of polymer materials in biomedicine. At present, other anticoagulant methods or new "anticoagulants" have inaccurate effects and many complications, which cannot fundamentally solve the problem. Therefore, the surface of biological materials must be modified to improve the anticoagulant performance of the surface. [0003] It has been found that immobilizing bioactive molecules on the surface of polymer materials can significantly increase and improve the specificity of biomaterials. There are many methods for surface modification of materials, physical methods have a short maintenance time, and chemical methods, such as ion...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K47/34A61K45/00A61P7/02A61L33/04A61L33/08A61L33/10A61L33/12A61L33/16A61L31/06A61L31/16A61K47/59
Inventor 宁建平文锐张义雄李延超代思源
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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