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Method for producing refined pure hawthorn extract tablets

A production method and tablet technology, which is applied in the field of processing fresh hawthorn pulp or concentrated hawthorn juice, can solve the problems that the health care or pharmacological effects of active ingredients of hawthorn cannot be well reflected, and the content of active ingredients of hawthorn is limited.

Inactive Publication Date: 2011-04-27
ANHUI YUANLONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are researchers who carry out research or products of hawthorn fermentation treatment at present, what are adopted are traditional acetic acid bacteria, which can only produce hawthorn beverage or vinegar containing hawthorn components (CN200610041240.1 Production method of hawthorn fermented biological beverage; ZL CN200610047030.3 hawthorn acetic acid fermented beverage and its brewing method; CN97105943.8 hawthorn fermented acetic acid beverage and its production method;), the content of active ingredients of hawthorn in the final product is limited, which cannot well reflect the health care or pharmacological effects of hawthorn active ingredients

Method used

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  • Method for producing refined pure hawthorn extract tablets
  • Method for producing refined pure hawthorn extract tablets
  • Method for producing refined pure hawthorn extract tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1. the production of primary hawthorn juice

[0025] Using conventional water infiltration process, according to figure 1 The above steps can extract the soluble components of the hawthorn by pressing and extracting to obtain the original hawthorn juice, which is the special primary hawthorn juice in the description of this patent, which can be used for subsequent fermentation and processing.

[0026] Pick out the hawthorns that have deteriorated and infested with insects, wash to remove dirt such as sediment, and directly cook or crush the hawthorn fruit (the crushing treatment step can speed up the soaking speed and improve the dissolution of soluble solids). Add pure water to the hawthorn fruit (according to the weight ratio of hawthorn / water = 1 / 3-10), slowly heat and maintain at 65-80°C for about 4-5 hours to soak for about 4-5 hours, fully soften the hawthorn pulp, squeeze to obtain hawthorn juice and Remove insoluble solids (skin, core, etc.) by filtr...

Embodiment 2

[0027] Embodiment 2. the production of fermented hawthorn juice

[0028] Primary hawthorn juice is rich in carbohydrates and nitrogen sources, but with a pH between 2.0 and 3.0, it is difficult for Saccharomyces cerevisiae and Aspergillus to grow in it, but Pichia pastoris can grow normally in it. Therefore, through a large number of comparative research experiments, we adopted the wild-type Pichia pastoris strain (X33, Invitrogen) as the strain for fermentation. The operation process is as follows:

[0029] Dilute the primary hawthorn juice 3 times with water, discharge it into the fermenter, and pasteurize the diluted primary hawthorn juice at 65-70°C for 60 minutes according to the standard operation procedure of Pichia pastoris fermentation, cool to 30°C and maintain it Under the temperature, according to 1:20 (seed liquid: diluted primary hawthorn juice, v / v), transfer to the Pichia pastoris seed liquid, set the stirring speed to 200 rpm, and the dissolved oxygen is not ...

Embodiment 3

[0030] Example 3. Determination of Total Flavonoids in Hawthorn Extract or Hawthorn Juice

[0031] Refer to the method for the determination of total flavonoids in hawthorn leaves in "Detection Methods of Health Food Functional Components" edited by Wang Guangya, China Light Industry Press (2002 edition P29-31) and "Chinese Pharmacopoeia" 2005 edition (P22-23). Rutin is used as a standard, and the amount of total flavonoids in the sample can be determined. Because the hawthorn juice obtained in this patent is all water-soluble extracts in hawthorn, and the water-insoluble components are very few, so the original assay method has been improved, and steps such as reflux and extraction have been omitted, and the reproducibility of the method is improved. Well, the assay is quick and easy.

[0032] The instruments and equipment used in the determination process mainly include desktop centrifuge, 751 type spectrophotometer, electronic balance (accuracy ≥ 0.1mg), sampler (Gilson), ...

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Abstract

The invention relates to a production method for removing or reducing sugar, pectin and tannic acid components in fresh hawthorn pulp or concentrated hawthorn juice by a Pichiapastoris fermentation process and keeping multiple active ingredients such as flavonoids, total phenolic acids and the like at the same time, and application of refined pure hawthorn extract tablets prepared from the hawthorn juice produced by the method by microwave vacuum drying in health care and medicaments.

Description

technical field [0001] The invention relates to a method for processing fresh hawthorn pulp or concentrated hawthorn juice through a microbial fermentation process. The method can effectively optimize various biologically active components such as flavonoids and total phenolic acids in the hawthorn extract, so that the health care and medicine of hawthorn can be improved. Uses are enhanced. Background technique [0002] Hawthorn belongs to the deciduous shrubs or small trees of Rosaceae. Its fruit is commonly known as red fruit. There are more than 280 species in the world, and there are 19 species in China. Hawthorn has been used as medicine in many countries in the world since ancient times. In my country, there are three kinds of hawthorn with large fruit (Crataegus pinnatifdaBge.), mountain red (C. pinnatifida Bunge var. major N.E. Brown) and wild hawthorn (C. cuneata Sieb. et Zucc.). Traditional Chinese medicine is used to call the first two kinds of "Northern Hawthorn...

Claims

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Application Information

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IPC IPC(8): A23L1/28A23L2/84A23L2/04A23L1/212A23L1/29A23L2/10A23P1/02A61K36/734A61K131/00A23L31/10A23P10/28
Inventor 张淑芸高松陆黎华沈英黄秀东杨阪钧
Owner ANHUI YUANLONG BIOTECH
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