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Method for preparing volatile oil inclusion compound and application thereof

A technology of volatile oil inclusion compound and volatile oil, which is applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve the problems of large dosage of pills and not very good taste, and achieves expansion of clinical and market applicability, improvement of taste, and reduction of stimulating effect

Active Publication Date: 2011-04-06
KANGMEI PHARMA
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  • Abstract
  • Description
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Problems solved by technology

But the dosage of the pills is large and the taste is not very good

Method used

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  • Method for preparing volatile oil inclusion compound and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Screening of volatile oil inclusion methods

[0029] The inclusion process of volatile oil is generally saturated aqueous solution method, grinding method, ultrasonic method and homogeneous method. Considering the operability and industrialization of the process, this example only examines the saturated aqueous solution method, ultrasonic method and homogeneous method.

[0030] Preparation method of clathrate: According to the conditions of each experiment, accurately weigh an appropriate amount of β-cyclodextrin, put it in a beaker, add an appropriate amount of distilled water, heat and stir to dissolve, and make a clear solution, and keep the temperature to the clathrate temperature. Add 1ml of volatile oil dropwise under stirring for inclusion, record the time, place in a refrigerator at 2-8°C for about 48h, filter with suction, wash with 10-20ml of ether several times in small amounts (washing away unincluded volatile oil), dry at 40°C for about 4h, A whi...

Embodiment 2

[0040] Example 2 Screening and validation of volatile oil inclusion process conditions

[0041] 1) Investigation of inclusion effect of dissolved volatile oil with different ethanol concentrations

[0042] Weigh 3 parts of 5g β-CD in the Erlenmeyer flask, add a certain amount of distilled water, heat and dissolve to make 5% β-CD saturated aqueous solution, and use 10ml of ethanol (95%, 80%, 65% ) was dissolved, and inclusion was carried out by homogeneous method.

[0043] The results are shown in Table 2, which shows that the clathrate effect of dissolving the volatile oil with 95% ethanol is the best.

[0044] Table 2 The inclusion rate of volatile oil dissolved in different concentrations of ethanol

[0045] 95% ethanol

80% ethanol

65% ethanol

85.7％

80.2％

74.3％

[0046] 2) Investigation of the effects of inclusion of volatile oil with different amounts of ethanol

[0047] Weigh 3 parts of 5g β-CD into the Erlenmeyer flask, add a ...

Embodiment 4

[0071] Example 4 Preparation of Huoxiang Zhengqi Water

[0072] According to the preparation method under the item of Huoxiang Zhengqi Water in Chinese Pharmacopoeia 2005 edition, the remaining prescription ingredients of Huoxiang Zhengqi Water were prepared: Atractylodes Rhizoma Atractylodis, Tangerine Peel, Magnolia officinalis, and Angelica dahurica were respectively used as solvents with 60% ethanol, and percolation was carried out after soaking for 24 hours. Collect 400ml of the first eluting solution for each of the three types, and collect 500ml of the first eluting solution for the latter, and set aside for further percolation. Add water to boil Poria cocos, soak twice at 80°C for 3 hours for the first time and 2 hours for the second time, and take the juice; soak the raw pinellia in cold water, change the water every 8 hours, soak until the heart is clear, and add dried Ginger 13.5g, decoct twice with water, 3 hours for the first time, 2 hours for the second time; d...

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Abstract

The invention provides a method for preparing a volatile oil inclusion compound and application thereof. The method for preparing the volatile oil inclusion compounds comprises the step of: including patchouli and volatile oil in perilla frutescens with beta-cyclodextrin through a homogeneous method. The inclusion compound prepared by the method can be used for preparing Huoxiang Zhengqishui so that the Huoxiang Zhengqishui can be free of alcohol, obtains improved stability, has no irritation and good mouth feeling, thereby enlarging the clinic and market application range of the Huoxiang Zhengqishui.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a method for preparing an inclusion compound of volatile oil and an application thereof, in particular to a method for preparing Huoxiang Zhengqi Water. Background technique [0002] Huoxiang Zhengqi Prescription comes from the famous Chinese medicine book "Hejiju Prescription". The so-called unhealthy qi refers to dysfunction of the spleen and stomach, resulting in vomiting and diarrhea. Huoxiang Zhengqi Formula is composed of Huoxiang, Dabupi, Angelica dahurica, Perilla, Poria, Pinellia Qu, Atractylodes Rhizoma, Tangerine Peel, Magnolia officinalis, and Zhilicorice. It has the functions of relieving the exterior and neutralizing the body, regulating qi and removing dampness. Indications exogenous wind-cold. The clinical manifestations mainly include fever (low-grade fever), chills, headache, fullness in the chest and diaphragm, abdominal pain, nausea an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61K47/48A61P1/08A61P1/12A61P29/00A61K47/69
Inventor 向飞军许冬瑾马兴田薄雯映林楠
Owner KANGMEI PHARMA
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