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Medical magnesium alloy biodegradability in-vitro dynamic simulation test equipment

A technology of biodegradation and dynamic simulation, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve problems such as difficult to accurately predict the biodegradation performance of materials/device in vivo, unavoidable shearing effect, discount of clinical reference value, etc., to improve R&D efficiency and R&D quality, compact structure, and strong versatility

Inactive Publication Date: 2012-08-08
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method is simple and easy to implement, it has the following main disadvantages: 1) It ignores the important influence of the relative motion of the material / medium on the corrosion degradation behavior of the material except convection
The biomedical application of magnesium alloy is just around the corner, especially when it is used as a coronary stent, it will inevitably be sheared by flowing body fluids such as blood, tissue fluid, etc.; It is difficult to accurately predict the in vivo biodegradability of materials / devices, which greatly reduces its clinical reference value, thus losing the due significance of in vitro research

Method used

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  • Medical magnesium alloy biodegradability in-vitro dynamic simulation test equipment
  • Medical magnesium alloy biodegradability in-vitro dynamic simulation test equipment
  • Medical magnesium alloy biodegradability in-vitro dynamic simulation test equipment

Examples

Experimental program
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Effect test

Embodiment

[0037] Taking the dynamic simulation test of the biodegradability of the medical magnesium alloy by the present invention as an example, the usage of the present invention is described in detail below: the pre-configured test medium such as Hank's simulated body fluid etc. is injected through the supply port 32 on the top of the liquid storage tank 2 Liquid storage tank 2; turn on the power switch of constant temperature tank 1, preset the temperature, heat the test medium and keep it constant temperature; carry out metallographic grinding, cleaning, drying, Micro-arc / anodizing, bionic passivation and other pre-treatments, and then screw / press it into the loading end 44 of the lower sample carrier 7; fix the lower sample carrier 7 to the test chamber 6 through the positioning hole 41 and the positioning pin 25 Bilge; open the circulation pump 3, and send the test medium into the power tank 5 and the test chamber 6; fix the gas gauge 8 vertically directly above the sample, adjus...

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Abstract

The invention discloses medical magnesium alloy biodegradability in-vitro dynamic simulation test equipment, which comprises a power tank, a test bin, a lower sample loading device, an air metering device, a liquid suction pipe, a first return pipe, a second return pipe and the like, wherein the liquid suction pipe, the first return pipe and the second return pipe are arranged in a liquid tank respectively; the liquid tank is placed in a constant-temperature tank; a flowmeter is fixed vertically; the lower sample loading device is positioned in the test bin; the air metering device is vertically fixed over the lower sample loading device; the power tank and the test bin are horizontally fixed an adjustable-height base respectively; and the suction pipe and the inlet of a circulating pump as well as the outlet of the circulating pump and the inlet of the flowmeter, the outlet of the flowmeter and the inlet pipe of the power tank, the outlet pipe of the power tank and the inlet pipe of the test bin, the outlet pipe of the test bin and the first return pipe and the overflow pipe of the power tank and the second return pipe are connected by water pipes to form a liquid medium circulating path. The equipment can realize the controlled flowing of liquid in a circulating system and the real-time collection and synchronous accurate metering of an insoluble gas product.

Description

technical field [0001] The invention belongs to the field of material performance testing technology and equipment, and relates to a device for dynamic simulation test and evaluation of material corrosion degradation performance in a fluid medium, especially suitable for biomedical materials / apparatus such as medical magnesium alloy and its medical equipment biodegradation In vitro dynamic simulation testing of performance. Background technique [0002] For materials serving in a liquid environment, such as medical devices implanted in the human body, ships in seawater, etc., the relative motion between them and the medium has a very important impact on their corrosion degradation behavior. Studies have shown that this relative movement can not only change the corrosion degradation rate of the material / device, but also change its corrosion degradation type and its mechanism. Therefore, simulating the actual service conditions, especially the relative movement between the en...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N17/00G01N7/18
Inventor 张永君刘斌王治平刘通耿利红
Owner SOUTH CHINA UNIV OF TECH
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