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Tissue temperature indicating element for ultrasound therapy

A technology of indicating element and tissue, applied in the field of tissue temperature indicating element, can solve the problems of blocking eyes, unable to achieve fast enough temperature control, impractical visual inspection of thermally active film, etc., to achieve the effect of avoiding the method

Active Publication Date: 2011-02-09
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

US Patent No. 6,454,730 has the disadvantage that a sufficiently fast control of the temperature at the skin surface cannot be achieved
Furthermore, visual inspection of thermally active membranes is not practical because the ultrasonic transducer blocks the viewer's eyes

Method used

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  • Tissue temperature indicating element for ultrasound therapy
  • Tissue temperature indicating element for ultrasound therapy
  • Tissue temperature indicating element for ultrasound therapy

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0109] 65 parts by weight of polymer (which is commercially available from Merck under the name LCP93; below is the chemical formula, degree of polymerization m+n=40; ​​transition from smectic to isotropic at 97°C according to Merck)

[0110] With 35 parts by weight of ethoxylated bisphenol-A diacrylate (trade name is Sartomer 349, which can be purchased from Sartomer, USA). The two materials have a similar refractive index of about 1.55, avoiding light scattering when the liquid crystal polymer LCP093 is heated above its liquid crystal transition temperature. For curing, the samples were mixed with 2 parts by weight of photoinitiator (trade name Irgacure 651, which is available from Ciba Specialty Chemicals in Switzerland). The mixture forms a paste that can be printed onto a substrate with the aid of a PDMS mold. Curing is achieved by using a UV light source PL10 lamp (Philips - intensity 0.6mW.cm- 2 365nm light) irradiation. The sample changed in appearance from highly...

example 2

[0112] Figure 6 The liquid crystal molecules are mixed with ethoxylated bisphenol A diacrylate. UV light was used to photopolymerize the mixture in the presence of a photoinitiator (2 weight percent Irgacure 651, commercially available from Ciba Specialty Chemicals, Sweden). The transition temperature from scattering to clear was subsequently observed between 60°C and 61°C using a charge-coupled device (CCD) camera.

example 3

[0114] A mixture of biocompatible polymer (poly(lactic-co-glycolic acid, PLGA), liquid crystal (n-pentylcyanobiphenyl) and dichloroethylene (DCE) as a solvent is injected into the water through an inkjet nozzle (The ratio of PLGA: LC: DCE is 0.05: 0.20: 99.75, and 0.3 weight percent of polyvinyl alcohol is added as a stabilizer to H 2 O to prevent coalescence of the emulsion droplets), and LC-filled polymer capsules were obtained. After water removal, the capsules were dispersed in the monomer system (ethoxylated bisphenol-A + 2 weight percent Irgacure 651 from Ciba Specialty Chemicals), and the resulting mixture was cured by photopolymerization of the monomer system . The transition temperature from scattering to clear was then observed at 35°C and occurred within a temperature interval not exceeding 1°C.

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Abstract

The present invention relates to a hydrogel-containing temperature indicating element for use in ultrasound therapy. The temperature indicating element of the present invention and the therapeutic device and method making use of the same enable in some embodiments an automated adaptation of the power output as a function of the tissue temperature, avoiding therefore overheating or burning of the skin.

Description

technical field [0001] The present invention relates to a tissue (such as skin or mucous membrane) temperature indicating element. The invention also relates to a device and a method for controlling the power output or lateral distribution of the transmitted power of an ultrasound transducer. The present invention also relates to the use of ultrasound-transparent and temperature-responsive hydrogels to monitor the temperature of mammalian tissue (eg, skin or mucous membranes) exposed to ultrasound energy. The invention can be used as dosimetry for ultrasound therapy for wound healing and sports medicine. Background technique [0002] High-intensity focused ultrasound (HIFU) is currently clinically approved for the treatment of uterine fibroids. Preliminary results of the technique show that it is a good candidate for remotely destroying undesired tissue deep within the body with minimal side effects to surrounding structures. The method consists in rapidly heating the pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01K11/16C09K19/38A61N7/02C09K19/52
CPCA61N7/02G01K11/165C09K19/52A61B2017/00084C09K19/38C09K19/408G01K11/16
Inventor C·S·霍尔R·库尔特
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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