Human basic fibroblast growth factor eye drops and preparation method thereof
A technology of fibroblasts and growth factors, applied in the directions of organic active ingredients, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of poor treatment effect, waste of active ingredients, blocking sight, etc., and shorten the healing time. , Repair wounds, avoid the effect of immune response
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preparation Embodiment 1
[0032]Prepare 100ml of eye drops: Dissolve 1g of sodium hyaluronate in 40ml of water for injection and set aside; take another 50ml of water for injection, add 5g of mannitol and 0.9g of sodium chloride, add 100μg of human basic fibroblasts after completely dissolving Growth factors, then add the sodium hyaluronate solution prepared in advance, mix well, add water for injection to the required volume and add sodium hydroxide solution at the same time to make the pH 7.0, use a 0.2-0.5 μm microporous membrane Filter and sterilize, and pack the filtrate into eye drop plastic bottles to make the eye drop finished product of the present invention.
preparation Embodiment 2
[0034] Prepare 100ml eye drops: Dissolve 1g of sodium hyaluronate completely in 40ml of water for injection for later use; take another 50ml of water for injection, add 0.3g of ethyl p-hydroxybenzoate, 5g of mannitol, 1g of human serum albumin, 0.9g of chlorine Sodium chloride, after completely dissolving, add 100 μg of human basic fibroblast growth factor, then add the sodium hyaluronate solution prepared in advance, mix well, add water for injection to the required volume and add sodium hydroxide solution at the same time to make When the pH is 7.0, it is sterilized by filtration with a microporous membrane of 0.2-0.5 μm, and the filtrate is dispensed into eye drop plastic bottles to prepare the finished eye drop product of the present invention.
preparation Embodiment 3
[0036] Prepare 100ml eye drops: Dissolve 1g sodium hyaluronate completely in 40ml water for injection for later use; take another 50ml water for injection, add 0.3g ethyl p-hydroxybenzoate, 0.01g heparin sodium, 5g mannitol, 1g human serum white Protein, 0.9g sodium chloride, after completely dissolved, add 100μg human basic fibroblast growth factor, then add the sodium hyaluronate solution prepared in advance, mix well, add water for injection to the required volume and add The pH of the sodium hydroxide solution is 7.0, and it is sterilized by filtration with a microporous membrane of 0.2-0.5 μm, and the filtrate is dispensed into eye drop plastic bottles to prepare the finished eye drop product of the present invention.
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