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Hydrogel woundplast containing traditional Chinese medicine extracts and preparation method thereof

A hydrogel and band-aid technology, applied in the field of medical supplies, can solve problems such as health hazards, and achieve the effects of good comfort, excellent mechanical properties, and good biocompatibility

Inactive Publication Date: 2017-01-11
CHINA PHARM UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adding antibacterial ingredients to hydrogel can endow the hydrogel with antibacterial function, but long-term use of chemical antibacterial agents will cause health hazards

Method used

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  • Hydrogel woundplast containing traditional Chinese medicine extracts and preparation method thereof
  • Hydrogel woundplast containing traditional Chinese medicine extracts and preparation method thereof
  • Hydrogel woundplast containing traditional Chinese medicine extracts and preparation method thereof

Examples

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preparation example Construction

[0035] Preparation of Coptidis Rhizome Extract: Grind Coptidis Rhizoma Coptidis and add it to 12 times volume fraction of 60% ethanol solution for soaking overnight, then conduct ultrasound at 45°C for 1 hour, ultrasonic power is 250W, filter while hot, concentrate the filtrate and freeze-dry , to obtain the Coptidis Rhizoma extract, wherein the content of berberine hydrochloride is 25.0%, the content of palmatine is 6.0%, the content of coptisine is 5.4%, and the content of epiberberine is 3.8%;

[0036] Preparation of honeysuckle extract: crush honeysuckle, add 10 times the amount of ethanol solution with a volume fraction of 60% to soak overnight, perform ultrasonication at 40°C for 45min, ultrasonic power is 250W, filter while hot, concentrate the filtrate and freeze-dry. The honeysuckle extract was obtained, wherein the content of chlorogenic acid was 5.4%.

Embodiment 1

[0038] (1) Take by weighing 0.8g chitosan, join in the acetic acid solution that 36mL mass concentration is 1.2%, stir evenly, form solution A;

[0039] (2) Weigh 1.0 g of polyvinyl alcohol, add it to 15 mL of distilled water for heating and dissolving, stir evenly, cool down, and form solution B;

[0040] (3) Weigh 0.2g of gelatin, add it to 14mL of distilled water, and swell at 60°C to form solution C;

[0041] (4) Weigh 0.8g menthol, add in 5mL absolute ethanol solution, stir evenly, form solution D;

[0042] (5) Weigh 0.2 g of Coptidis rhizome extract, add it into 10 mL of ethanol solution with a volume fraction of 60%, and stir evenly to form solution E;

[0043] (6) Weigh 1.0 g of honeysuckle extract, add it to 20 mL of ethanol solution with a volume fraction of 60%, and stir evenly to form solution F;

[0044] (7) Add solutions B, C, D, E, F and 0.8 mL of glycerol to solution A in sequence, and stir evenly to form solution G;

[0045] (8) The solution G is subjected ...

Embodiment 2

[0049] (1) Take by weighing 1.6g chitosan, join in the acetic acid solution that 30mL mass concentration is 1.2%, stir evenly, form solution A;

[0050] (2) Weigh 2.0 g of polyvinyl alcohol, add it to 12 mL of distilled water for heating and dissolving, stir evenly, cool down, and form solution B;

[0051] (3) Weigh 0.6g of gelatin, add it to 12mL of distilled water, and swell at 60°C to form solution C;

[0052] (4) Weigh 1.6g of menthol, add it to 3mL of absolute ethanol solution, and stir evenly to form solution D;

[0053] (5) Weigh 0.5 g of Coptidis rhizome extract, add it into 20 mL of ethanol solution with a volume fraction of 60%, and stir evenly to form solution E;

[0054] (6) Weigh 1.0 g of honeysuckle extract, add it to 20 mL of ethanol solution with a volume fraction of 60%, and stir evenly to form solution F;

[0055] (7) Add solutions B, C, D, E, F and 1.2 mL of glycerin to solution A in sequence, and stir evenly to form solution G;

[0056] (8) The solution ...

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Abstract

The invention relates to a hydrogel woundplast containing traditional Chinese medicine extracts and a preparation method thereof. The hydrogel woundplast comprises a back lining layer, a medicated hydrogel layer and a stripping layer. The preparation method comprises the following steps: uniformly mixing the following components in percentage by weight: 0.5-4.0% of chitosan, 1.0-3.0% of polyvinyl alcohol, 0.2-1.0% of gelatin, 1.0-3.0% of glycerol, 0.5-2.5% of menthol, 0.2-1.0% of coptis extract, 1.0-2.5% of honeysuckle flower extract, 15-25% of anhydrous ethanol and 50-80% of distilled water; performing cyclic refrigerating-melting treatment to obtain the medicated hydrogel layer; bonding the back lining layer on one side of the hydrogel layer; and bonding the stripping layer on the other side of the hydrogel layer. The hydrogel woundplast containing traditional Chinese medicine extracts is simple in structure and convenient to use, and can absorb wound surface exudates and keep wound wetness; and meanwhile, the hydrogel woundplast has the effects of resisting bacteria, diminishing inflammation and stopping bleeding, and can effectively accelerate wound healing.

Description

technical field [0001] The invention relates to a band-aid and a preparation method thereof, in particular to a hydrogel band-aid containing Chinese medicine extract and a preparation method thereof, belonging to the technical field of medical supplies. Background technique [0002] Band-aid is a medical product that protects wounds, prevents wound contamination, and promotes wound healing. Traditional band-aids have the advantages of small size, simple use, and convenient portability. However, the adhesive tape used has poor air permeability, and the sweat normally secreted by the human body cannot pass through the adhesive tape, so it is easy to cause skin wrinkles. At the same time, the wound pad layer of the traditional band-aid cannot keep the wound moist, and it is easy to adhere to the wound, causing secondary damage. [0003] Hydrogel is a network polymer swelling body containing a large amount of water, which is widely used in wound dressings, artificial skin, bon...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28A61L15/26A61L15/24A61L15/40A61L15/42A61L15/44A61L15/46
CPCA61L15/32A61L15/24A61L15/26A61L15/28A61L15/40A61L15/42A61L15/44A61L15/46A61L2300/30A61L2300/404A61L2300/41A61L2300/418A61L2400/04C08L89/06C08L5/08C08L29/04C08L75/04
Inventor 钟文英吴灿陈乔何苏云王俊玲
Owner CHINA PHARM UNIV
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