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Composite, raw material composition, bone repair body, preparation method and application

A raw material composition and composite material technology, applied in the field of medical biomaterials, can solve the problems of poor osteogenic performance, mismatched mechanical properties, bone resorption, etc., and achieve the effects of improved osteogenic activity and excellent mechanical properties

Active Publication Date: 2020-03-31
上海禾麦医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The technical problem to be solved by the present invention is to overcome the disadvantages of bone repair materials in the prior art, such as insufficient biological activity and poor osteogenic performance, which lead to easy loosening after implantation in the human body, or mismatch between mechanical properties and bone tissue, and easy to cause bone resorption, etc. A composite material, raw material composition, bone restoration, preparation method and application are provided

Method used

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  • Composite, raw material composition, bone repair body, preparation method and application
  • Composite, raw material composition, bone repair body, preparation method and application
  • Composite, raw material composition, bone repair body, preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0127] The preparation method of PT25 material: 8.10kg of tantalum powder with a volume fraction of 25% and a particle size of 1-3 μm and 1.90 kg of polyether ketone ketone powder with a volume fraction of 75% and a particle size of 30-40 μm are mixed at high speed Machine mixing to obtain mixed powder; then use twin-screw extruder to extrude the mixed powder to granulate, the extrusion temperature of the extruder is 370 ° C ~ 380 ° C; the extrusion pressure is 80 MPa ~ 100 MPa; the particle size of the extrusion masterbatch is 2-5mm; then use the injection molding machine to inject the masterbatch to obtain the product, the injection temperature is 370-380°C; the pressure of the injection molding machine is 80-120MPa.

[0128] The preparation method of PT50 material: Mix 18.56kg of tantalum powder with a volume fraction of 50% and a particle size of 1-3 μm and 1.44 kg of PEKK powder with a volume fraction of 50% and a particle size of 30-40 μm with a high-speed mixer. Obtain ...

Embodiment 2

[0130] The preparation method of PT25 material: 8.10kg of tantalum powder with a volume fraction of 25% and a particle size of 1-3 μm and 1.90 kg of polyether ketone ketone powder with a volume fraction of 75% and a particle size of 30-40 μm are mixed at high speed Machine mixing to obtain mixed powder; then use a twin-screw extruder to extrude the mixed powder to obtain the product. The extrusion temperature of the extruder is 370°C to 380°C; the extrusion pressure is 80MPa to 100MPa. The SEM photos of the surface and cross-sectional morphology of the prepared PT25 material are shown in figure 1 Figures d, e, and f in Fig.

[0131] The preparation method of PT50 material: Mix 18.56kg of tantalum powder with a volume fraction of 50% and a particle size of 1 to 3 μm and 1.44 kg of polyether ketone ketone powder with a volume fraction of 50% and a particle size of 30 to 40 μm at high speed Machine mixing, mixed powder; all the other steps are the same as the preparation method ...

Embodiment 3

[0136] Preparation method of PT50 bone prosthesis: 18.56 kg of tantalum powder with a volume fraction of 50% and a particle size of 1-3 μm and 1.44 kg of polyetherketone-ketone powder with a volume fraction of 50% and a particle size of 30-40 μm are used A high-speed mixer mixes to obtain a mixed powder; all the other steps are the same as in Example 1 (using the mold of the artificial joint). The mechanical properties of the obtained PT50 bone restorations are shown in Table 1.

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Abstract

The invention discloses a composite, a raw material composition, a bone repair body, a preparation method and an application. The raw material composition of the composite comprises the following components of tantalum material powder and polyaryletherketone powder, wherein the volume ratio of the tantalum material powder to the polyaryletherketone powder is(1:4) to (1:1), and the particle diameter of the tantalum material powder is 100nm-5 [mu]m. The composite prepared by the composition has favorable bioactivity and compatibility, is good in mechanical properties, can promote cell adhering,proliferation and polarization, can stimulate bone growth, can accelerate bone healing, and can reduce healing time after a bone implant material is implanted. The bone repair body prepared by the composition cannot cause inflammatory reaction after being implanted, the mechanical properties of the bone repair body including modulus of elasticity, toughness, rupture strength and the like, can cooperate with human bones, and the bone repair body cannot cause negative effect of loosening of the bone repair material caused by stress shielding, bone absorption and the like, and can meet requirements of clinical application for bone repair.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a composite material, a raw material composition, a bone restoration, a preparation method and an application. Background technique [0002] With the accelerated aging of my country's population and more and more patients with bone defects, osteomyelitis, and nonunion caused by various traumas, tumors, or bone diseases, the demand for bone repair materials has increased year by year, which has greatly facilitated the development of such materials. The materials used clinically to repair bone defects include medical metals, medical polymers, bioglass, bioceramics and their composite materials. When the bone repair material is implanted in the body, the osteoblasts in the body will adhere to the surface of the material and grow, and be induced to form bone. Finally, the material will be well bonded with the new bone tissue, that is, osseointegration, and bone repair will be real...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/50A61L27/54A61L27/56A61L31/12A61L31/14A61L31/16
CPCA61L27/446A61L27/50A61L27/54A61L27/56A61L31/128A61L31/14A61L31/146A61L31/16A61L2300/404A61L2300/412A61L2400/18A61L2430/02A61L2430/12A61L2430/24A61L2430/38C08L61/16
Inventor 魏杰汤亭亭胡兴龙梅师奇杨立利赵君黄孝敏
Owner 上海禾麦医学科技有限公司
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