Parnaparin production method

A production method and parparparin technology are applied in the field of preparation of biochemical drugs to achieve the effects of high yield, low bleeding risk and good product stability

Active Publication Date: 2012-11-28
DONGYING TIANDONG PHARM CO LTD
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

There is no domestic production of this product that meets the requirements of the European Pharmacopoeia, and the product is not included in the US Pharmacopoeia

Method used

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  • Parnaparin production method

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Embodiment Construction

[0007] combined with figure 1 , to further describe the present invention:

[0008] Take heparin sodium and dissolve in purified water to a concentration of 2% to 3%, add sodium acetate and sodium chloride, adjust the pH to 7 to 8, add dissolved copper acetate, and add 2% to 3% hydrogen peroxide (v / v volume ratio, the same below), put it in a water bath at 50-55°C, and start the reaction, during which the pH and temperature are controlled. After 18-24 hours of degradation reaction, adjust the pH to 9.5-10.0, add EDTA.2Na (disodium ethylenediamine tetraacetate), and react for 4 hours, adjust the pH to neutral, precipitate with 3 times the amount of ethanol, and place it for 21 hours. Dissolve the resulting precipitate to a concentration of 10% to 15%, and treat it with a strong acidic cationic resin, such as a 001X7 resin bed, collect the effluent, and adjust the pH to neutral. After the resin treatment is completed, add 3 times the amount of medicinal Ethanol precipitation, ...

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Abstract

The invention relates to a preparation method of a biochemical medicament, in particular to a parnaparin production method. The invention adopts a technical scheme that the parnaparin production method comprises the following steps: adding sodium acetate and sodium chloride to a heparin sodium solution the concentration of which is 2-3%, adjusting the pH value to 7-8, respectively adding dissolved Cu<2+>, adding hydrogen peroxide the concentration of which is 2-3%, and keeping in a water bath at 50-55 DEG C to be subject to a degradation reaction; and removing heavy metal, decolorizing and freeze-drying to obtain the parnaparin product. The method has the advantage of simple operation and can realize industrial production. In the presence of Cu<2+>, the heparin reacts with the peroxide under alkaline conditions to degrade. However, the degradation reaction is quite random, glycosidic bonds among uronic acids or glucosamines has the possibility of being broken, and the obtained productis composed of multiple sugar chains.

Description

1. Technical field: [0001] The invention relates to a preparation method of biochemical medicines, in particular to a production method of paparin. 2. Background technology: [0002] Paparin is an anticoagulant and antithrombotic drug, a kind of low molecular weight heparin, an antithrombotic agent with rapid and sustained long-acting effect, and has the lowest risk of bleeding. Paparin is a low-molecular-weight heparin obtained through the separation and purification of patented chemical methods. The usual method is to degrade heparin with hydrogen peroxide under the catalysis of copper ions. There is no domestic production of this product that meets the requirements of the European Pharmacopoeia, and the product is not included in the US Pharmacopoeia. 3. Contents of the invention: [0003] The object of the present invention is exactly to aim at the above-mentioned defect that prior art exists, provides a kind of paparin production method, has determined the optimum co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/10
Inventor 郭林李荣崔慧斐
Owner DONGYING TIANDONG PHARM CO LTD
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