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Pharmaceutical composition for curing tristimania and preparation method and application thereof

A composition and medicine technology, applied in the field of preparation of traditional Chinese medicine compositions, can solve the problems of low toxic and side effects, failure to industrialize and market, toxic and side effects, etc., and achieve the effect of safe therapeutic effect

Inactive Publication Date: 2010-12-22
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a drug with good curative effect according to the problem that the existing medicines for treating depression mainly use traditional dosage forms such as decoctions and powders with addition and subtraction of some basic prescriptions, which have not been industrialized and marketized, and have toxic and side effects. , a pharmaceutical composition with low toxic and side effects

Method used

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  • Pharmaceutical composition for curing tristimania and preparation method and application thereof
  • Pharmaceutical composition for curing tristimania and preparation method and application thereof
  • Pharmaceutical composition for curing tristimania and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1 Acquired despair animal model experiment

[0051] Methods: 60 Kunming mice, half male and half male, weighing 18-20 g. Under normal diet, natural light, 12h light-dark cycle, room temperature (23±1)°C, and quiet environment, raise them for 3 days to adapt to the environment. Then they were randomly divided into 4 groups according to body weight, 15 rats in each group, namely blank control group, amitriptyline hydrochloride group, high-dose antidepressant Chinese medicine (guizhi, morinda officinalis, licorice, white peony root, keel, jujube seed) group , antidepressant traditional Chinese medicine low dose group. The blank control group was given normal saline, administered by intragastric administration at 0.2ml / 10g, once a day, and administered continuously for 10 days; the amitriptyline hydrochloride group started with a normal diet for 7 days, did not give any drugs, and administered amitriptyline hydrochloride three days before the experiment. Mitrip...

Embodiment 2

[0066] Example 2 Chronic Unpredictable Stress Model Experiment

[0067] Methods: Choose healthy adult SD rats, weighing 180g-200g, and raise them in a quiet environment with normal diet, natural light, light-dark cycle of 12h, room temperature (23±1)°C, and adapt to the environment for 3 days. Immediately in a quiet room, the autonomous activity test was carried out for behavioral scoring, and rats with close scoring levels were selected from qualified persons (50<horizontal movement score<220), and were randomly divided into 4 groups, 8 in each group, i.e. blank control group , model group, high-dose antidepressant Chinese medicine group, and low-dose antidepressant Chinese medicine group. The blank control group was not given any stimulation, was fed normally, was given normal saline, and administered by intragastric administration at 10ml / Kg, once a day, for 43 consecutive days. The depression model group was reared in a single cage, given normal saline, and administered b...

Embodiment 3

[0105] The preparation of embodiment 3 capsules

[0106] Guizhi 10kg Morinda officinalis 15kg Licorice 10kg

[0107] Take the above-mentioned raw material medicine, add 4 times the volume of water to cassia twig, steam distillation to extract the volatile oil for 3 hours; dilute the volatile oil with an equal amount of ethanol, mix it with β-cyclodextrin and water at a ratio of 1ml:5g:70ml, and heat it at room temperature Stir and clathrate until there is no volatile oil smell, and dry at low temperature to obtain the β-cyclodextrin inclusion complex of volatile oil, pulverize, sieve, and set aside; Morinda officinalis and licorice plus 30-90 volume % ethanol are reflux extracted twice, each Add 6 times the volume of alcohol, reflux for 2 hours, filter the alcohol liquid, recover ethanol from the filtrate, concentrate under reduced pressure, dry, pulverize, mix with volatile oil β-cyclodextrin inclusion compound fine powder, add 15wt% microcrystalline cellulose, Granulated wi...

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Abstract

The invention discloses a pharmaceutical composition for curing tristimania and a preparation method and an application thereof. The pharmaceutical composition comprises the following components in parts by mass: 3-60 parts of cassia twig, 3-60 parts of liquorice and 6-90 parts of Morinda officinalis. Based on different properties of drugs, the invention respectively adopts the modes of extracting by volatile oil, decocting by water, extracting by ethanol and the like to extract effective components so as to obtain the pharmaceutical composition in the invention. The pharmaceutical composition has the efficacies of regulating heart-yang, keep ying and weiqi balance, tonifying qi and calming heart, can be used for preparing drugs for curing tristimania and has obvious and safe curative effect on tristimania with small toxic or side effect.

Description

technical field [0001] The invention relates to the field of preparation of traditional Chinese medicine compositions, in particular to a pharmaceutical composition for treating depression, a preparation method and application thereof. Background technique [0002] Depression refers to a type of mood disorder syndrome characterized by low mood, slow thinking, accompanied by psychomotor retardation symptoms such as decreased interest and decreased initiative, and the degree can range from mild sadness, depression, low self-esteem, self-blame, to severe self-guilt, despair, suicidal tendencies, etc. With the development of society and the continuous acceleration of the pace of life, the incidence of depression has increased year by year, and it has become a high incidence in modern society. It is called "the psychiatric cold" by experts in psychiatry and psychology. The global incidence rate of depression is 3-5%, and the recurrence rate is as high as 85%. In countries and re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/746A61P25/24A61K35/02
Inventor 何伟沈雪梅丁元庆
Owner GUANGDONG PHARMA UNIV
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