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Method for extracting and purifying Pinostrobin from medicinal plants, and pharmaceutical preparation and application thereof

The technology of a medicinal plant, condyloconidin, is applied in the field of life sciences, which can solve the problems of cumbersome operation and excessive use of toxic solvents, and achieve the effects of simple extraction and purification operations, efficient resource utilization, and less resistance to secondary drugs

Inactive Publication Date: 2012-12-12
马灵媛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the existing patent (CN1666745A) and (Application No.: 2007101445360) have reported the method of extracting and purifying ballobacham, it has the characteristics of cumbersome operation and the use of many toxic solvents, and there is no report on the treatment of gastrointestinal diseases with ballchafenin preparations.

Method used

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  • Method for extracting and purifying Pinostrobin from medicinal plants, and pharmaceutical preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1. Preparation of Condominin Extract from the Peel of Hickory Nut

[0022] Take the fresh pecan fleshy peel, put it in a homogenate extractor, add 10 times the amount of ethanol with a concentration of 90%, homogenize twice at a high speed, each time for 1 min, filter the extract, combine the filtrate, concentrate and recover under reduced pressure Ethanol (60 ℃, 0.09 Mpa) to extract the relative density of 1.12, stand still for 20 min, remove the supernatant, and obtain the precipitate as the extract of ballechinin.

Embodiment 2

[0023] Example 2. Preparation of Coneconolin Extract from the Root of Saffron

[0024] Take the dried root, remove impurities, slice, add 5 times the amount of water to soak for 24 hours, then place it in a tissue homogenate extractor, add 15 times the amount of ethanol with a concentration of 90%, and homogenize at high speed for 3 times, Each time for 5 minutes, filter the extract, combine the filtrate, concentrate under reduced pressure and recover ethanol (60 ℃, 0.09 Mpa) to the relative density of the extract 1.15, let it stand still for 20 minutes, remove the supernatant, and obtain the precipitate that is ballocchinin Extract.

Embodiment 3

[0025] Example 3. Preparation of Condominin Extract from Oxytropis falciparum Whole Herb

[0026] Take fresh Oxytropis falciparum herb, remove impurities, cut into sections, put it in a tissue homogenate extractor, add 12 times the amount of 80% ethanol, homogenize twice at high speed, each time for 2 min, and filter the extract , combined the filtrates, concentrated under reduced pressure and recovered ethanol (60 ℃, 0.09 Mpa) to the relative density of the extract of 1.10, left it standing still for 20 min, removed the supernatant, and obtained the extract of ballocchinin as the precipitate.

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Abstract

The invention relates to a method for extracting and purifying Pinostrobin from medicinal plants, and a pharmaceutical preparation and application thereof. The invention particularly discloses a method for extracting and purifying Pinostrobin from medicinal plants, and a pharmaceutical preparation and application thereof in preparing medicines for treating gastroenteropathy, and belongs to the field of life sciences. The method comprises the following steps: extracting medicinal plants with 70-95% ethanol homogenate; and after the extract is concentrated to a certain volume, standing to precipitate, removing a supernatant, dissolving the obtained precipitate with an organic solvent, separating by gel-resin column chromatography, crystallizing and recrystallizing to obtain the Pinostrobin monomer of which the purity is higher than 90%. The Pinostrobin monomer in which different excipients can be added is prepared into any common pharmaceutical formulation. The pharmaceutical preparation has obvious biological activity on peptic ulcer, gastritis, stomachache, gastric evacuation (gasterectasis), alimentary tract tumors and the like caused by Helicobacter pylori infection, and has thecharacteristic of no toxic or side effect.

Description

technical field [0001] The present invention relates to the field of life sciences, in particular to a method for extracting and purifying ballocchinin from medicinal plants, its pharmaceutical preparation and its application in the preparation of medicines for treating gastrointestinal diseases. Background technique [0002] Gastrointestinal disease is a common and frequently-occurring disease in the world today, which seriously endangers human health. In recent years, with the continuous improvement of human living standards, irregular diet, immune dysfunction, Helicobacter pylori infection and intake of harmful substances have led to various gastric diseases such as bloating, gastric acid, acute and chronic gastritis, peptic ulcer and even gastric cancer. Enteropathy seriously affects the healthy life of human beings. At present, traditional Chinese medicine preparations and chemically synthesized drugs are mainly used in the clinical treatment of gastrointestinal diseas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/32C07D311/40A61K31/352A61P31/04A61P1/04A61P35/00
Inventor 马灵媛
Owner 马灵媛
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